Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
that in humans is encoded by the ''MAPK7''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
MAPK7 is a member of the
MAP kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses t ...
family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (
MAP2K5
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the ''MAP2K5'' gene.
Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase famil ...
/
MEK5). It is involved in the downstream signaling processes of various receptor molecules including
receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high- affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine ...
s, and
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
s. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by
phosphorylating, and activating different
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The fu ...
s. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
MAPK7 is also critical for cardiovascular development
and is essential for
endothelial
The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vesse ...
cell function.
Interactions
MAPK7 has been shown to
interact with:
*
C-Raf
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the ''RAF1'' gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase ...
,
*
Gap junction protein, alpha 1
*
MAP2K5
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the ''MAP2K5'' gene.
Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase famil ...
,
*
MEF2C,
*
MEF2D
Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the ''MEF2D'' gene.
Interactions
MEF2D has been shown to interact with:
* CABIN1,
* EP300,
* MAPK7,
* Myocyte-specific enhancer factor 2A,
* NFATC2
* Sp1 transcr ...
,
[
* PTPRR,]SGK
Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (comparTreefam family TF320906. In most vertebrates, including humans, there are three isoforms encoded by the genes ''SGK1' ...
,
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
MAP Kinase Resource
.
{{Portal bar, Biology, border=no
EC 2.7.11