In molecular biology the MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family of

proteins Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

are a group of membrane associated proteins with highly divergent functions. Included are the 5-lipoxygenase-activating protein (gene FLAP),

leukotriene C4 synthase Leukotriene C4 synthase is an enzyme that in humans is encoded by the ''LTC4S'' gene. The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. T ...

(), which catalyzes the production of

leukotriene C4 Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast cells, its biosynthesis is orchestrated by translocation to the nuclear envelope along with c ...

(LTC4) from

leukotriene A4 Leukotriene A4 (LTA4) is a leukotriene, and is the precursor for the productions of LTB4 (leukotriene B)) and LTC4 (leukotriene C4). Biosynthesis of Leukotriene A4 Following the biosynthesis of eicosanoid, triggered as a result of infection or ...

(LTA4), and microsomal glutathione S-transferase II () (GST-II), which also produces LTC4 from LTA4. Another example is

prostaglandin E synthase Prostaglandin E synthase (, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2. The synthase generating PGE2 is a membrane-associat ...

. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by

cyclooxygenase Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, ) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prosta ...

from

arachidonic acid Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6), or 20:4(5,8,11,14). It is structurally related to the saturated arachidic acid found in cupuaçu butter. Its name derives from the New Latin word ''arachi ...

). Because of structural similarities in the active sites of FLAP, LTC4 synthase, and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.

Subfamilies

*5-lipoxygenase-activating protein

Human proteins containing this domain

* 5-lipoxygenase-activating protein (ALOX5AP)) *

LTC4S Leukotriene C4 synthase is an enzyme that in humans is encoded by the ''LTC4S'' gene. The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. Th ...

MGST1 Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the ''MGST1'' gene. Function The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which ...

MGST2 Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the ''MGST2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''ge ...

* MGST3 * PTGES

References

{{InterPro content, IPR001129 Protein domains Protein families