Mitogen-activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular
signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellula ...
.
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MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the ''MAP4K1'' gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation ...
(aka HPK1)
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MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the ''MAP4K2'' gene.
Function
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is ...
(aka GCK)
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MAP4K3
Mitogen-activated protein kinase kinase kinase kinase 3 is a protein that in humans is encoded by the MAP4K3 gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity. ...
(aka GLK)
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MAP4K4
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) – also known as hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) and Nck-interacting kinase (NIK) – is an enzyme, specifically a serine/threonine (S/T) k ...
(aka HGK)
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MAP4K5
Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the ''MAP4K5'' gene.
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yea ...
(aka KHS)
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MAP4K6
Misshapen-like kinase 1 is an enzyme that in humans is encoded by the ''MINK1'' gene.
Function
Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to t ...
(aka MINK)
Images
File:Signal transduction pathways.svg, Some signal transduction pathways. MAP4K is not labelled.
File:MAPKpathway.jpg, MAPK pathway. Some (or all) of the MAP4Ks in this image are labelled by other names, such as HPK1 and GCK.
See also
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellula ...
*
MAP kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses ...
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MAP kinase kinase
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).
MAP2K is classified as .
There are seven genes:
* (a.k.a. MEK1)
* (a.k ...
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MAP kinase kinase kinase
Mitogen Activated Protein (MAP) kinase kinase kinase, MAPKKK (or MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP kinase. Several types of MAPKKK can exist but ar ...
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List of unusual biological names
The trouble with unusual names has not been lost on scientists when needing to explain genetic diseases to lay-people. This has particularly been noted in patients with a defect in the sonic hedgehog gene pathway and the disease formerly named CA ...
References
{{biochemistry-stub
Protein families