M54 or M-54 may be:
Roads:
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M54 motorway, a motorway in England also known as the Telford Motorway
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M-54 (Michigan highway)
M-54 is a north–south state trunkline highway in the US state of Michigan that bypasses the city of Flint. It is named Dort Highway for much of its length, in honor of Flint carriage and automobile pioneer Josiah Dallas Dort. The portion fr ...
, a state highway in Michigan
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M54 (Cape Town), a Metropolitan Route in Cape Town, South Africa
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M54 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa
Vehicles:
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BMW M54, a 2000 automobile engine
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M54 (truck), a heavy truck used by the United States armed forces
Astronomy:
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Messier 54, a globular cluster in the constellation Sagittarius
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