This article lists

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

s by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission (EC) numbering system. * List of EC numbers (EC 5) * List of EC numbers (EC 6)

:Oxidoreductases (EC 1) (
Oxidoreductase In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually ...
)

* Dehydrogenase * Luciferase * DMSO reductase

:EC 1.1 (act on the CH-OH group of donors)

* :EC 1.1.1 (with NAD⁺ or NADP⁺ as acceptor) ** Alcohol dehydrogenase (NAD) ** Alcohol dehydrogenase (NADP) ** Homoserine dehydrogenase ** Aminopropanol oxidoreductase ** Diacetyl reductase **

Glycerol dehydrogenase Glycerol dehydrogenase (, also known as nicotinamide adenine dinucleotide, NAD+-linked glycerol dehydrogenase, glycerol: NAD+ 2-oxidoreductase, GDH, GlDH, GlyDH) is an enzyme in the oxidoreductase family that utilizes the NAD+ to catalyze the oxida ...

** Propanediol-phosphate dehydrogenase ** glycerol-3-phosphate dehydrogenase (NAD+) ** D-xylulose reductase **

L-xylulose reductase Dicarbonyl/L-xylulose reductase, also known as carbonyl reductase II, is an enzyme that in human is encoded by the DCXR gene located on chromosome 17. Structure The DCXR gene encodes a membrane protein that is approximately 34 kDa in size a ...

** Lactate dehydrogenase ** Malate dehydrogenase ** Isocitrate dehydrogenase **

HMG-CoA reductase HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, ; NADPH-dependent, ) of the mevalonate pathway, the metabolic pathway that produces cholesterol and ot ...

* :EC 1.1.2 (with a

cytochrome Cytochromes are redox-active proteins containing a heme, with a central Fe atom at its core, as a cofactor. They are involved in electron transport chain and redox catalysis. They are classified according to the type of heme and its mode of ...

as acceptor) * :EC 1.1.3 (with

oxygen Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements ...

as acceptor) ** Glucose oxidase ** L-gulonolactone oxidase ** Thiamine oxidase ** Xanthine oxidase * :EC 1.1.4 (with a disulfide as acceptor) * :EC 1.1.5 (with a

quinone The quinones are a class of organic compounds that are formally "derived from aromatic compounds uch as benzene or naphthalene">benzene.html" ;"title="uch as benzene">uch as benzene or naphthalene] by conversion of an even number of –CH= group ...

or similar compound as acceptor) * :EC 1.1.99 (with other acceptors)

:EC 1.2 (act on the aldehyde or oxo group of donors)

* :EC 1.2.1 (with NAD⁺ or NADP⁺ as acceptor) ** Acetaldehyde dehydrogenase **

Glyceraldehyde 3-phosphate dehydrogenase Glyceraldehyde 3-phosphate dehydrogenase (abbreviated GAPDH) () is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long establishe ...

** Pyruvate dehydrogenase * :EC 1.2.4 **

Oxoglutarate dehydrogenase The oxoglutarate dehydrogenase complex (OGDC) or α-ketoglutarate dehydrogenase complex is an enzyme complex, most commonly known for its role in the citric acid cycle. Units Much like pyruvate dehydrogenase complex (PDC), this enzyme forms a com ...

:EC 1.3 (act on the CH-CH group of donors)

* :EC 1.3.1 (with NAD⁺ or NADP⁺ as acceptor) ** Biliverdin reductase * :EC 1.3.2 (with a

as acceptor) * :EC 1.3.3 (with

as acceptor) ** Protoporphyrinogen oxidase * :EC 1.3.5 (with a

or similar compound as acceptor) * :EC 1.3.7 (with an

iron–sulfur protein Iron–sulfur proteins (or iron–sulphur proteins in British spelling) are proteins characterized by the presence of iron–sulfur clusters containing sulfide-linked di-, tri-, and tetrairon centers in variable oxidation states. Iron–sulfur c ...

as acceptor) * :EC 1.3.99 (with other acceptors)

:EC 1.4 (act on the CH-NH₂ group of donors)

* :EC 1.4.3 ** Monoamine oxidase

:EC 1.5 (act on CH-NH group of donors)

* :EC 1.5.1 (with NAD⁺ or NADP⁺ as acceptor) **

Dihydrofolate reductase Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry ...

Methylenetetrahydrofolate reductase Methylenetetrahydrofolatereductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the ''MTHFR'' gene. Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrah ...

* :EC 1.5.3 (with

as acceptor) ** Sarcosine oxidase **

Dihydrobenzophenanthridine oxidase Dihydrobenzophenanthridine oxidase (DHBP oxidase) is an enzyme. In the IUBMB Enzyme Nomenclature, dihydrobenzophenanthridine oxidase is . Dihydrobenzophenanthridine oxidase produces oxidized forms of benzophenanthridine alkaloids: * In ''Sanguin ...

* :EC 1.5.4 (with a disulfide as acceptor) * :EC 1.5.5 (with a

or similar compound as acceptor) * :EC 1.5.7 (with an

as acceptor) * :EC 1.5.8 (with a flavin as acceptor) * :EC 1.5.99 (with other acceptors)

:EC 1.6 (act on NADH or NADPH)

* :EC 1.6.1 (with NAD⁺ or NADP⁺ as acceptor) * :EC 1.6.2 (with a

as acceptor) * :EC 1.6.3 (with

as acceptor) *EC 1.6.4 now :EC 1.8.1 * :EC 1.6.5 (with a

or similar compound as acceptor) ** NADH dehydrogenase * :EC 1.6.6 (with a

nitrogen Nitrogen is the chemical element with the symbol N and atomic number 7. Nitrogen is a nonmetal and the lightest member of group 15 of the periodic table, often called the pnictogens. It is a common element in the universe, estimated at se ...

ous group as acceptor) *EC 1.6.7 now :EC 1.18.1 *EC 1.6.8 now :EC 1.5.1 * :EC 1.6.99 (with other acceptors)

:EC 1.7 (act on other nitrogenous compounds as donors)

* :EC 1.7.1 (with NAD⁺ or NADP⁺ as acceptor) * :EC 1.7.2 (with a

as acceptor) * :EC 1.7.3 (with

as acceptor) ** Urate oxidase * :EC 1.7.7 (with an

as acceptor) * :EC 1.7.99 (with other acceptors) ** Nitrite reductase ** Nitrate reductase

:EC 1.8 (act on a sulfur group of donors)

* :EC 1.8.1 (with NAD⁺ or NADP⁺ as acceptor) ** Glutathione reductase **

Thioredoxin reductase Thioredoxin reductases (TR, TrxR) () are enzymes that reduce thioredoxin (Trx). Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. In bacteria TrxR also catalyzes the reduction ...

* :EC 1.8.2 (with a

as acceptor) * :EC 1.8.3 (with

as acceptor) ** Sulfite oxidase * :EC 1.8.4 (with a disulfide as acceptor) * :EC 1.8.5 (with a

or similar compound as acceptor) *EC 1.8.6 deleted, included in EC 2.5.1.18 * :EC 1.8.7 (with an

as acceptor) * :EC 1.8.98 (with other, known, acceptors) * :EC 1.8.99 (with other acceptors)

:EC 1.9 (act on a heme group of donors)

* :EC 1.9.3 (with

as acceptor) ** Cytochrome c oxidase * :EC 1.9.6 (with a

ous as acceptor) *EC 1.9.99 transferred, now EC 1.9.98.1

:EC 1.10 (act on
diphenol Diphenol may refer to: * Benzenediols * Bisphenol The bisphenols () are a group of chemical compounds related to diphenylmethane. Most are based on two hydroxyphenyl functional groups linked by a methylene bridge. Exceptions include bisphenol S, ...
s and related substances as donors)

* :EC 1.10.1(with NAD⁺ or NADP⁺ as acceptor) * :EC 1.10.2 (with a

as acceptor) **

Coenzyme Q - cytochrome c reductase A cofactor is a non- protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases the rate of a chemical reaction). Cofactors can be considered "helper molecules" that as ...

* :EC 1.10.3 (with

as acceptor) ** Catechol oxidase **

Laccase Laccases () are multicopper oxidases found in plants, fungi, and bacteria. Laccases oxidize a variety of phenolic substrates, performing one-electron oxidations, leading to crosslinking. For example, laccases play a role in the formation of l ...

* :EC 1.10.99 (with other acceptors)

:EC 1.11 (act on
peroxide In chemistry, peroxides are a group of compounds with the structure , where R = any element. The group in a peroxide is called the peroxide group or peroxo group. The nomenclature is somewhat variable. The most common peroxide is hydrogen p ...
as an acceptor -- peroxidases)

* :EC 1.11.1 ( peroxidases) **

Cytochrome c peroxidase Cytochrome ''c'' peroxidase, or CCP, is a water-soluble heme-containing enzyme of the peroxidase family that takes reducing equivalents from cytochrome ''c'' and reduces hydrogen peroxide to water: :CCP + H2O2 + 2 ferrocytochrome ''c'' + 2H+ � ...

Catalase Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a very important enzyme in protecting t ...

** Myeloperoxidase **

Thyroid peroxidase Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine re ...

** Glutathione peroxidase

:EC 1.12 (act on hydrogen as a donor)

* :EC 1.12.1 (with NAD⁺ or NADP⁺ as acceptor) * :EC 1.12.2 (with a

as acceptor) * :EC 1.12.5 (with a

or similar compound as acceptor) * :EC 1.12.7 (with an

as acceptor) * :EC 1.12.98 (with other known acceptors) * :EC 1.12.99 (with other acceptors)

:EC 1.13 (act on single donors with incorporation of molecular oxygen)

* :EC 1.13.11 (With incorporation of two atoms of oxygen) ** 4-hydroxyphenylpyruvate dioxygenase () * :EC 1.13.12 (With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)) ** Renilla-luciferin 2-monooxygenase ** Cypridina-luciferin 2-monooxygenase ** Firefly luciferase ** Watasenia-luciferin 2-monooxygenase ** Oplophorus-luciferin 2-monooxygenase

:EC 1.14 (act on paired donors with incorporation of molecular oxygen)

* Cytochrome P450 oxidase * :Cytochrome P450 ** Aromatase ** CYP2D6 **

CYP2E1 Cytochrome P450 2E1 (abbreviated CYP2E1, ) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, inclu ...

CYP3A4 Cytochrome P450 3A4 (abbreviated CYP3A4) () is an important enzyme in the body, mainly found in the liver and in the intestine. It oxidizes small foreign organic molecules ( xenobiotics), such as toxins or drugs, so that they can be removed from ...

** Cytochrome P450 oxidase * :EC 1.14.12 **

Nitric oxide dioxygenase Nitric oxide dioxygenase () is an enzyme that catalyzes the conversion of nitric oxide (NO) to nitrate (NO) . The net reaction for the reaction catalyzed by nitric oxide dioxygenase is shown below: * 2NO + 2O2 + Nicotinamide adenine dinucleotide p ...

* :EC 1.14.13 **

Nitric oxide synthase Nitric oxide synthases () (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and perist ...

* :EC 1.14.14 ** Aromatase ** CYP2D6 **

* :EC 1.14.16 ** Phenylalanine hydroxylase * :EC 1.14.18 ** Tyrosinase

:EC 1.15 (act on superoxide radicals as acceptors)

* :EC 1.15.1 **

Superoxide dismutase Superoxide dismutase (SOD, ) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide () radical into ordinary molecular oxygen (O2) and hydrogen peroxide (). Superoxide is produced as a by-product of oxygen ...

:EC 1.16 (oxidize metal ions)

* :EC 1.16.3 ** Ceruloplasmin

:EC 1.17 (act on CH or CH₂ groups)

* :EC 1.17.1 **

Leucoanthocyanidin reductase In enzymology, a leucoanthocyanidin reductase () (LAR, aka leucocyanidin reductase or LCR) is an enzyme that catalyzes the chemical reaction :(2R,3S)-catechin + NADP+ + H2O \rightleftharpoons 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+ The 3 s ...

** Xanthine dehydrogenase ** Nicotinate dehydrogenase ** 4-hydroxy-tetrahydrodipicolinate reductase * :EC 1.17.2 ** Nicotinate dehydrogenase (cytochrome) * :EC 1.17.3 ** Xanthine oxidase * :EC 1.17.4 **

Ribonucleotide reductase Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. It catalyzes this formation by removing the 2'-hydroxyl group of t ...

** Ribonucleoside-triphosphate reductase ** Vitamin K epoxide reductase ** Vitamin-K-epoxide reductase (warfarin-sensitive) ** Vitamin-K-epoxide reductase (warfarin-insensitive) ** RRM1 ** RRM2 **

RRM2B Ribonucleotide-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the ''RRM2B'' gene. The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designa ...

* :EC 1.17.5 ** Caffeine dehydrogenase * :EC 1.17.7 * :EC 1.17.99

:EC 1.18 (act on iron–sulfur proteins as donors)

* :EC 1.18.6 ** Nitrogenase

:EC 1.19 (act on reduced flavodoxin as donor)

* :EC 1.19.6 ** Nitrogenase (flavodoxin)

:EC 1.20 (act on phosphorus or arsenic as donors)

* :EC 1.20.1 * :EC 1.20.2 * :EC 1.20.4 ** Arsenate reductase (glutaredoxin) **

Glutaredoxin Glutaredoxins (also known as Thioltransferase) are small redox enzymes of approximately one hundred amino-acid residues that use glutathione as a cofactor. In humans this oxidation repair enzyme is also known to participate in many cellular funct ...

* :EC 1.20.9 * :EC 1.20.99

:EC 1.21 (act on X-H and Y-H to form an X-Y bond)

* :EC 1.21.1 ** Iodotyrosine deiodinase * :EC 1.21.3 **

Isopenicillin N synthase Isopenicillin N synthase (IPNS) is a non-heme iron protein belongig to the 2-oxoglutarate (2OG)-dependent dioxygenases oxidoreductase family. This enzyme catalyzes the formation of isopenicillin N from δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valin ...

** Tetrahydrocannabinolic acid synthase * :EC 1.21.4 * :EC 1.21.99 ** Thyroxine 5-deiodinase ** Iodothyronine deiodinase and

:EC 1.97 (other oxidoreductases)

* :EC 1.97.1 ** Deiodinase

:Transferases (EC 2) (
Transferase A transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor). They are involved in hundreds o ...
)

Glutathione S-transferase Glutathione ''S''-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) ...

:EC 2.1 (transfer one-carbon groups, Methylase)

* :EC 2.1.1 ** Catechol-O-methyl transferase ** DNA methyltransferase , , **

Histone methyltransferase Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine N-methyltransferases), that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues ...

, * :EC 2.1.3 **

Aspartate transcarbamoylase Aspartate carbamoyltransferase (also known as aspartate transcarbamoylase or ATCase) catalyzes the first step in the pyrimidine biosynthetic pathway (). In '' E. coli'', the enzyme is a multi-subunit protein complex composed of 12 subunits (30 ...

** Ornithine transcarbamoylase

:EC 2.2 (transfer
aldehyde In organic chemistry, an aldehyde () is an organic compound containing a functional group with the structure . The functional group itself (without the "R" side chain) can be referred to as an aldehyde but can also be classified as a formyl gro ...
or
ketone In organic chemistry, a ketone is a functional group with the structure R–C(=O)–R', where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group –C(=O)– (which contains a carbon-oxygen double b ...
groups)

* :EC 2.2.1 ** Transketolase ** Transaldolase ** Acetolactate synthase ** 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

:EC 2.3 (acyltransferases)

* :EC 2.3.1 ** Aminolevulinic acid synthase **

Choline acetyltransferase Choline acetyltransferase (commonly abbreviated as ChAT, but sometimes CAT) is a transferase enzyme responsible for the synthesis of the neurotransmitter acetylcholine. ChAT catalyzes the transfer of an acetyl group from the coenzyme acetyl-Co ...

* :EC 2.3.2 ** Factor XIII ** Gamma glutamyl transpeptidase **

Transglutaminase Transglutaminases are enzymes that in nature primarily catalyze the formation of an isopeptide bond between γ-carboxamide groups ( -(C=O)NH2 ) of glutamine residue side chains and the ε-amino groups ( -NH2 ) of lysine residue side ...

:EC 2.4 (glycosyltransferases)

* :EC 2.4.2 **

Hypoxanthine-guanine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme encoded in humans by the ''HPRT1'' gene. HGPRT is a transferase that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. This r ...

:EC 2.5 * :EC 2.5.1 ** Thiaminase

:EC 2.5 (transfer
alkyl In organic chemistry, an alkyl group is an alkane missing one hydrogen. The term ''alkyl'' is intentionally unspecific to include many possible substitutions. An acyclic alkyl has the general formula of . A cycloalkyl is derived from a cycloa ...
or
aryl In organic chemistry, an aryl is any functional group or substituent derived from an aromatic ring, usually an aromatic hydrocarbon, such as phenyl and naphthyl. "Aryl" is used for the sake of abbreviation or generalization, and "Ar" is used ...
groups, other than
methyl In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula . In formulas, the group is often abbreviated as Me. This hydrocarbon group occurs in ...
groups)

** Flavin prenyltransferase

:EC 2.6 (transfer nitrogenous groups)

* :EC 2.6.1 ** Alanine transaminase ** Aspartate transaminase

:EC 2.7 (transfer phosphorus-containing groups)

* :EC 2.7.2 **

Butyrate kinase In enzymology, a butyrate kinase () is an enzyme that catalyzes the chemical reaction :ADP + butyryl-phosphate \rightleftharpoons ATP + butyrate Thus, the two substrates of this enzyme are ADP and butyryl-phosphate, whereas its two products ar ...

()

:EC 2.8 (transfer sulfur-containing groups)

* :

Thiosulfate sulfurtransferase Rhodanese, also known as rhodanase, thiosulfate sulfurtransferase, thiosulfate cyanide transsulfurase, and thiosulfate thiotransferase, ...

* : 3-mercaptopyruvate sulfurtransferase * : Thiosulfate—thiol sulfurtransferase * : tRNA uracil 4-sulfurtransferase * : Thiosulfate—dithiol sulfurtransferase * : Biotin synthase * : Cysteine desulfurase * : Lipoyl synthase * : Molybdenum cofactor sulfurtransferase * :

Thiazole synthase Thiazole synthase (, ''thiG (gene)'') is an enzyme with systematic name ''1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase''. This enzyme catalyses the following chemical reaction A chemical reaction is a process that leads to the chem ...

* : Molybdopterin synthase sulfurtransferase * : Molybdopterin synthase * : tRNA-uridine 2-sulfurtransferase * : tRNA-5-taurinomethyluridine 2-sulfurtransferase * : tRNA-5-methyluridine(54) 2-sulfurtransferase

:EC 2.9 (transfer selenium-containing groups)

* : L-seryl-tRNA(Sec) selenium transferase * : O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase

:Hydrolases (EC 3) ( Hydrolase)

* Hydrolytic enzyme

:EC 3.1 (act on
ester In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides ...
bonds)

Nuclease A nuclease (also archaically known as nucleodepolymerase or polynucleotidase) is an enzyme capable of cleaving the phosphodiester bonds between nucleotides of nucleic acids. Nucleases variously effect single and double stranded breaks in their t ...

Endonuclease Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain. Some, such as deoxyribonuclease I, cut DNA relatively nonspecifically (without regard to sequence), while many, typically called restriction endonuclease ...

Exonuclease Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end (exo) of a polynucleotide chain. A hydrolyzing reaction that breaks phosphodiester bonds at either the 3′ or the 5′ end occurs. Its close relative is ...

* :EC 3.1.1 **

Acid hydrolase An acid hydrolase is an enzyme that works best at acidic pHs. It is commonly located in lysosomes, which are acidic on the inside. Acid hydrolases may be nucleases, proteases, glycosidases, lipases, phosphatases, sulfatases and phospholipas ...

** Phospholipase A () ** Acetylcholinesterase () ** Cholinesterase () **

Lipoprotein lipase Lipoprotein lipase (LPL) (EC 3.1.1.34, systematic name triacylglycerol acylhydrolase (lipoprotein-dependent)) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-solubl ...

() * :EC 3.1.2 ** Ubiquitin carboxy-terminal hydrolase L1 () * :EC 3.1.3 **

Phosphatase In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolase ...

Alkaline phosphatase The enzyme alkaline phosphatase (EC 3.1.3.1, alkaline phosphomonoesterase; phosphomonoesterase; glycerophosphatase; alkaline phosphohydrolase; alkaline phenyl phosphatase; orthophosphoric-monoester phosphohydrolase (alkaline optimum), systematic ...

() ** Fructose bisphosphatase () * :EC 3.1.4 ** Phospholipase C () **

CGMP specific phosphodiesterase type 5 Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme () from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum and the retina. It has also been recently discovered to p ...

() ** Phospholipase D () * :EC 3.1.21 **

Restriction enzyme A restriction enzyme, restriction endonuclease, REase, ENase or'' restrictase '' is an enzyme that cleaves DNA into fragments at or near specific recognition sites within molecules known as restriction sites. Restriction enzymes are one class ...

Type 1 () **

Type 2 () **

Type 3 () **

Type 4 (?) ** Deoxyribonuclease I () * :EC 3.1.26 ** RNase H () * :EC 3.1.27 **

Ribonuclease Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the ...

:EC 3.2 (act on sugars -
glycosylases Glycosylases ( EC 3.2) are enzymes that hydrolyze glycosyl compounds. They are a type of hydrolase (EC 3). In turn, glycosylases are divided into two groups: glycosidase Glycoside hydrolases (also called glycosidases or glycosyl hydrolases) ca ...
)

* :EC 3.2.1 ** Amylase () ** Sucrase () ** Chitinase () ** Lysozyme () ** Maltase () ** Lactase () **

Beta-galactosidase β-Galactosidase (EC 3.2.1.23, lactase, beta-gal or β-gal; systematic name β-D-galactoside galactohydrolase), is a glycoside hydrolase enzyme that catalyzes hydrolysis of terminal non-reducing β-D-galactose residues in β-D-galactosides. β ...

() ** Hyaluronidase ()

Function and clinical importance of some enzymes in category 3.2.1

Amylase

''Function'': Amylase is an enzyme that is responsible for the breaking of the bonds in starches, polysaccharides, and complex carbohydrates to be turned into simple sugars that will be easier to absorb. ''Clinical Significance'': Amylase also has medical history in the use of Pancreatic Enzyme Replacement Therapy (PERT). One of the components is Sollpura (liprotamase), which help in the breakdown of saccharides into simple sugars.

Lysozyme

''Function'': An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, and mucus. It functions as an antimicrobial agent by splitting the peptidoglycan component of bacterial cell walls, which then leads to cell death. ''Clinical Significance'': Toxic levels of blood are caused by the excessive production of lysozyme's by cancer cells. Lysozyme's have also been associated with Bronchopulmonary dysplasia (BPD) in newborns and is a key factor in providing the immunology of infants during breast feeding.

Sucrase

''Function'': Sucrase is a stomachs related protein that mobilizes hydrolysis to convert sucrose into glucose and fructose. ''Clinical Significance'': Low amounts of Sucrose also known as Sucrose intolerance happens when sucrose isn’t being discharged in the small digestive tract. A result of this is extra gas.

Lactase

''Function'': lactase is located in the small digestives system of people and other creatures such as mammals. Lactase is the bases of the total absorption of milk. ''Clinical Significance'': People who are lactose intolerant have medicine that can help with the digestion. When you are lactose intolerant you might experience gas, bloating, and pain along with other symptoms regarding your digestive system.

:EC 3.3 (act on
ether In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again ...
bonds)

* :EC 3.3 * Adenosylmethionine hydrolase *

S-adenosyl-L-homocysteine hydrolase S-adenosyl-L-homocysteine hydrolase () (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is a ubiquitous enzyme which binds ...

* Alkenylglycerophosphocholine hydrolase * Alkenylglycerophosphoethanolamine hydrolase * Cholesterol-5,6-oxide hydrolase * Hepoxilin-epoxide hydrolase * Isochorismatase *

Leukotriene-A4 hydrolase Leukotriene A4 hydrolase, also known as LTA4H is a human gene. The protein encoded by this gene is a bifunctional enzyme () which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase. Function This enzyme belongs to the famil ...

* Limonene-1,2-epoxide hydrolase * Microsomal epoxide hydrolase * Trans-epoxysuccinate hydrolase

:EC 3.4 (act on
peptide bond In organic chemistry, a peptide bond is an amide type of covalent chemical bond linking two consecutive alpha-amino acids from C1 (carbon number one) of one alpha-amino acid and N2 (nitrogen number two) of another, along a peptide or protein cha ...
s - Peptidase)

* :EC 3.4.11 **

Alanine aminopeptidase Membrane alanyl aminopeptidase () also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N) is an enzyme that in humans is encoded by the ANPEP gene. Function Aminopeptidase N is located in the small-intestinal and renal microvil ...

*:EC 3.4.15 **Angiotensin converting enzyme *:EC 3.4.21 **Serine protease **Chymotrypsin () **Trypsin () **Thrombin () **Factor X () **Plasmin () **Acrosin () **Factor VII () **Factor IX () **Prolyl oligopeptidase () **Factor XI () **Elastase () **Factor XII () **Proteinase K () **Tissue plasminogen activator () **Protein C () *:EC 3.4.22 **Separase () *:EC 3.4.23 **Pepsin () **Rennet () **Renin () **Trypsinogen () and (20/21/23/24/26) **Plasmepsin () *:EC 3.4.24 **Matrix metalloproteinase () *:EC 3.4.25 **Metalloendopeptidase

:EC 3.5 (act on carbon–nitrogen bonds, other than peptide bonds)

*:EC 3.5.1 (In linear amides) **Urease () *:EC 3.5.2 (In cyclic amides) **Beta-lactamase () *:EC 3.5.3 (In linear amidines) **Arginase () *:EC 3.5.4 (In cyclic amidines) **Adenosine deaminase () **GTP cyclohydrolase I () *:EC 3.5.5 (In nitriles) **Nitrilase ()

:EC 3.6 (act on acid anhydrides)

*:EC 3.6.1 **Helicase **DnaB helicase **RecQ helicase *:EC 3.6.3 **ATPase **NaKATPase () **ATP synthase ()

:EC 3.7 (act on carbon–carbon bonds)

* Kynureninase

:EC 3.8 (act on halide bonds)

* EC 3.8.1.3 Haloacetate dehalogenase

:EC 3.9 (act on phosphorus–nitrogen bonds)

* : Phosphoamidase * : Protein arginine phosphatase * : Phosphohistidine phosphatase

:EC 3.10 (act on sulfur–nitrogen bonds)

* : N-sulfoglucosamine sulfohydrolase * : Cyclamate sulfohydrolase

:EC 3.11 (act on carbon–phosphorus bonds)

* : Phosphonoacetaldehyde hydrolase * : Phosphonoacetate hydrolase * : Phosphonopyruvate hydrolase

:EC 3.12 (act on sulfur–sulfur bonds)

* : Trithionate hydrolase

:EC 3.13 (act on carbon–sulfur bonds)

* : UDP-sulfoquinovose synthase * : 2'-hydroxybiphenyl-2-sulfinate desulfinase * : 3-sulfinopropanoyl—CoA desulfinase * : Carbon disulfide hydrolase * : (CysO sulfur-carrier protein)-S-L-cysteine hydrolase * : Carbonyl sulfide hydrolase * : S-adenosyl-L-methionine hydrolase (adenosine-forming)

:Lyases (EC 4) (Lyase)

:EC 4.1 (carbon–carbon lyases)

*:EC 4.1.1 **Ornithine decarboxylase () **Uridine monophosphate synthetase () **Aromatic-L-amino-acid decarboxylase () **RubisCO () *:EC 4.1.2 **Fructose-bisphosphate aldolase ()

:EC 4.2 (carbon–oxygen lyases)

*:EC 4.2.1 **Carbonic anhydrase () **Tryptophan synthase ()

:EC 4.3 (carbon–nitrogen lyases)

*:EC 4.3.1 **Phenylalanine ammonia-lyase ()

:EC 4.4 (carbon–sulfur lyases)

*:EC 4.4.1 **Cystathionine gamma-lyase **Cystathionine beta-lyase **Leukotriene C4 synthase

:EC 4.5 (carbon–halide lyases)

*:EC 4.5.1 **Dichloromethane dehalogenase **Halohydrin dehalogenase

:EC 4.6 (phosphorus–oxygen lyases)

*:EC 4.6.1 **Adenylate cyclase () **Guanylate cyclase ()

:Isomerases (EC 5) (Isomerase)

:EC 5.1 (racemases and epimerases)

*:EC 5.1.1 * Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing) * Serine racemase *:EC 5.1.2 * Mandelate racemase *:EC 5.1.3 * UDP-glucose 4-epimerase *:EC 5.1.99 * Methylmalonyl CoA epimerase

:EC 5.2 (cis-trans-isomerases)

*:EC 5.2 * FKBP: FKBP1A * FKBP1B * FKBP2 * FKBP3 * FKBP4 * FKBP5 * FKBP6 * FKBP8 * FKBP9 * FKBP10 * FKBPL * Cyclophilin * Parvulin * Prolyl isomerase * 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase * Beta-carotene isomerase * Farnesol 2-isomerase * Furylfuramide isomerase * Linoleate isomerase * Maleate isomerase * Maleylacetoacetate isomerase * Maleylpyruvate isomerase * Parvulin * Photoisomerase * Prolycopene isomerase * Prolyl isomerase * Retinal isomerase * Retinol isomerase * Zeta-carotene isomerase

:EC 5.3 (Intramolecular reaction, intramolecular oxidoreductases)

*:EC 5.3.3 **Enoyl CoA isomerase () *:EC 5.3.4 **Protein disulfide isomerase ()

:EC 5.4 (intramolecular transferases -- mutases)

*:EC 5.4.2 **Phosphoglucomutase ()

:EC 5.5 (intramolecular lyases)

:EC 5.99 (other isomerases)

* :EC 5.99.1 ** Topoisomerase (type I: , type II: )

:Ligases (EC 6) (Ligase)

:EC 6.1 (form carbon–oxygen bonds)

6-carboxytetrahydropterin synthase * :EC 6.1.1 ** FARSB ()

:EC 6.2 (form carbon–sulfur bonds)

* : Acetate—CoA ligase * : Medium-chain acyl—CoA ligase * : Long-chain-fatty-acid—CoA ligase * : Succinate—CoA ligase (GDP-forming) * : Succinate—CoA ligase (ADP-forming) * : Glutarate—CoA ligase * : Cholate—CoA ligase * : Oxalate—CoA ligase * : Malate—CoA ligase * : Acid—CoA ligase (GDP-forming) * : Biotin—CoA ligase * : 4-coumarate—CoA ligase * : Acetate—CoA ligase (ADP-forming) * : 6-carboxyhexanoate—CoA ligase * : Arachidonate—CoA ligase * : Acetoacetate—CoA ligase * : Propionate—CoA ligase * : Citrate—CoA ligase * : Long-chain-fatty-acid-luciferin-component ligase * : Long-chain-fatty-acid-(acyl-carrier-protein) ligase * : Transferred entry: 6.2.1.30 * : (citrate (pro-3S)-lyase) ligase * : Dicarboxylate—CoA ligase * : Phytanate—CoA ligase * : Benzoate—CoA ligase * : o-succinylbenzoate—CoA ligase * : 4-hydroxybenzoate—CoA ligase * : 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase * : Transferred entry: 6.2.1.7 * : Phenylacetate—CoA ligase * : 2-furoate—CoA ligase * : Anthranilate—CoA ligase * : 4-chlorobenzoate—CoA ligase * : Trans-feruloyl-CoA synthase * : ACP-SH:acetate ligase * : 3-hydroxypropionyl-CoA synthase * : 3-hydroxybenzoate—CoA ligase * : (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase * : (butirosin acyl-carrier protein)—L-glutamate ligase * : 4-hydroxybutyrate-CoA ligase * : 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate-CoA ligase * : 3-oxocholest-4-en-26-oate-CoA ligase * : 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase * : 3-(methylthio)propionyl-CoA ligase * : E1 ubiquitin-activating enzyme * : L-allo-isoleucine--holo-CmaA peptidyl-carrier protein ligase * : Medium-chain-fatty-acid-(acyl-carrier-protein) ligase * : Carnitine-CoA ligase * : Long-chain fatty acid adenylyltransferase FadD28 * : 4-hydroxybenzoate adenylyltransferase FadD22 * : 4-hydroxyphenylalkanoate adenylyltransferase FadD29 * : L-firefly luciferin-CoA ligase * : L-proline-L-prolyl-carrier protein ligase * : D-alanine-D-alanyl-carrier protein ligase * : E1 SAMP-activating enzyme

:EC 6.3 (form carbon–nitrogen bonds)

* Glutamine synthetase () * Argininosuccinate synthetase () * CTP synthase ()

:EC 6.4 (form carbon–carbon bonds)

* Pyruvate carboxylase () * Acetyl-CoA carboxylase ()

:EC 6.5 (form phosphoric ester bonds)

* DNA ligase ()

:EC 6.6 (form nitrogen–metal bonds)

{{DEFAULTSORT:List Of Enzymes Biology-related lists, Enzymes Enzymes

:Oxidoreductases (EC 1) (Oxidoreductase In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually ...)