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corticosteroid ester Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involv ...
s, including
ester In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides ...
s of
steroid A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and ...
al glucocorticoids and
mineralocorticoid Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones. Mineralocorticoids are produced in the adrenal cortex and influence salt and water balances ( electrolyte balance and fluid balance). The primary ...
s.


Esters of natural corticosteroids


Desoxycortone esters

* Desoxycortone acetate (deoxycortone acetate; desoxycorticosterone acetate) * Desoxycortone cypionate (deoxycortone cypionate; desoxycorticosterone cypionate) * Desoxycortone enanthate (deoxycortone enanthate; deoxycorticosterone enanthate) * Desoxycortone glucoside (deoxycortone glucoside; deoxycorticosterone glucoside) * Desoxycortone pivalate (deoxycortone pivalate; deoxycorticosterone pivalate)


Hydrocortisone esters

* Benzodrocortisone (hydrocortisone 17-benzoate) * Hydrocortamate (hydrocortisone 21-(diethylamino)acetate) * Hydrocortisone aceponate (hydrocortisone 21-acetate 17α-propionate) * Hydrocortisone acetate * Hydrocortisone bendazac * Hydrocortisone buteprate (hydrocortisone 17α-butyrate 21-propionate) *
Hydrocortisone butyrate Hydrocortisone butyrate is a corticosteroid that comes in one of the following forms: * '' Hydrocortisone-17-butyrate'' — * '' Hydrocortisone-21-butyrate'' — It is a group IV corticosteroid under US classification. See also * Cortisol ...
(hydrocortisone 17α-butyrate) * Hydrocortisone 21-butyrate * Hydrocortisone cypionate (hydrocortisone cyclopentanepropionate) * Hydrocortisone phosphate *
Hydrocortisone succinate Hydrocortisone hemisuccinate (), also known as hydrocortisone hydrogen succinate () or simply hydrocortisone succinate and sold under the brand name Solu-Cortel among many others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ...
(hydrocortisone hemisuccinate) *
Hydrocortisone tebutate Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, asthma, ...
*
Hydrocortisone valerate Hydrocortisone valerate is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main class ...
*
Hydrocortisone xanthogenic acid Hydrocortisone is the name for the hormone cortisol when supplied as a medication. Uses include conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, asthma, ...


Esters of other natural corticosteroids

*
11-Dehydrocorticosterone acetate 11-Dehydrocorticosterone (11-DHC), also known as 11-oxocorticosterone or 17-deoxycortisone, as well as 21-hydroxypregn-4-ene-3,11,20-trione, is a naturally occurring, endogenous corticosteroid related to cortisone and corticosterone. It is a poten ...
*
Cortifen Cortifen, also known as cortiphen or kortifen, as well as fencoron, is a synthetic glucocorticoid corticosteroid and cytostatic antineoplastic agent which was developed in Russia for potential treatment of tumors. It is a hydrophobic chlor phen ...
(cortodoxone chlorphenacyl ester) *
Cortisone acetate Cortisone acetate (brand names Adreson, Cortison, Cortisone, Cortisone Acetate, Cortone, Cortistab, Cortisyl, others) is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed (under prescription) in many countries ...
*
Corticosterone acetate Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. It is of minor importance in humans, except in the very rare ...
*
Corticosterone benzoate Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. It is of minor importance in humans, except in the very rare ...
*
Cortodoxone acetate 11-Deoxycortisol, also known as cortodoxone (INN), cortexolone as well as 17α,21-dihydroxyprogesterone or 17α,21-dihydroxypregn-4-ene-3,20-dione, is an endogenous glucocorticoid steroid hormone, and a metabolic intermediate towards cortisol. It ...


Esters of synthetic corticosteroids


Beclometasone esters

*
Beclometasone dipropionate Beclomethasone, also known as beclomethasone dipropionate, and sold under the brand name Qvar among others, is a steroid medication. It is available as an inhaler, cream, pills, and nasal spray. The inhaled form is used in the long-term manageme ...
(beclomethasone dipropionate) * Beclometasone salicylate * Beclometasone valeroacetate


Betamethasone esters

* Betamethasone acetate * Betamethasone acibutate (betamethasone 21-acetate 17α-isobutyrate) * Betamethasone adamantoate * Betamethasone benzoate *
Betamethasone dipropionate Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressant, immunosuppressive abilities. It is applied as a topical cream, ointment, lotion or gel (Diprolene) to treat pruritus, itching and other skin cond ...
* Betamethasone divalerate * Betamethasone phosphate (betamethasone phosphate) * Betamethasone succinate *
Betamethasone valerate Betamethasone valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis ...
* Betamethasone valeroacetate (betamethasone 21-acetate 17α-valerate) * Cortobenzolone (betamethasone salicylate)


Clocortolone esters

* Clocortolone acetate * Clocortolone caproate * Clocortolone pivalate


Dexamethasone esters

* Dexamethasone acefurate * Dexamethasone acetate (flumeprednisolone) * Dexamethasone cipecilate * Dexamethasone diethylaminoacetate * Dexamethasone dipropionate * Dexamethasone isonicotinate * Dexamethasone linoleate * Dexamethasone metasulphobenzoate * Dexamethasone palmitate * Dexamethasone phosphate * Dexamethasone pivalate * Dexamethasone succinate * Dexamethasone sulfate * Dexamethasone tebutate (dexamethasone ''tert''-butylacetate) * Dexamethasone troxundate * Dexamethasone valerate


Fluocinolone acetonide esters

*
Ciprocinonide Ciprocinonide (developmental code name RS-2386), also known as fluocinolone acetonide cyclopropylcarboxylate, is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex ...
(fluocinolone acetonide cyclopropylcarboxylate) *
Fluocinonide Fluocinonide (sold under various brand names) is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusti ...
(fluocinolone acetonide 21-acetate) *
Procinonide Procinonide (developmental code RS-2362; also known as fluocinolone acetonide propionate) is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as ...
(fluocinolone acetonide propionate)


Fluocortolone esters

* Fluocortin (fluocortolone-21-carboxylate) *
Fluocortin butyl Fluocortin butyl (brand names Lenen, Novoderm, Varlane, Vaspit), or fluocortin 21-butylate, is a synthetic glucocorticoid corticosteroid which is marketed in Germany, Belgium, Luxembourg, Spain, and Italy. Chemically, it is the butyl In ...
(fluocortolone-21-carboxylate 21-butylate) * Fluocortolone caproate * Fluocortolone pivalate


Fluprednisolone esters

* Fluprednisolone acetate * Fluprednisolone succinate (fluprednisolone hemisuccinate) * Fluprednisolone valerate


Methylprednisolone esters

*
Methylprednisolone aceponate Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylpredn ...
*
Methylprednisolone acetate Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical an ...
* Methylprednisolone cyclopentylpropionate * Methylprednisolone phosphate * Methylprednisolone succinate (methylprednisolone hemisuccinate) * Methylprednisolone suleptanate


Prednisolone esters

* Prednazate ( prednisolone succinate and perphenazine compound) * Prednazoline ( prednisolone phosphate and
fenoxazoline Fenoxazoline (trade name Aturgyl in Brazil) is a nasal decongestant. Fenmetozole Fenmetozole (DH-524) is a drug which was patented as an antidepressant, but was later studied as an antagonist of the effects of ethanol, though results were po ...
compound) *
Prednicarbate Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. Corticosteroids have always been an important part of the pharmacological arsenal of dermatology Dermatology is the branch of medicine d ...
(prednisolone 17-(ethyl carbonate) 21-propionate) * Prednimustine (prednisolone
chlorambucil Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given by mouth. ...
ester) * Prednisolamate (prednisolone diethylaminoacetate) * Prednisolone acetate * Prednisolone hexanoate * Prednisolone metasulphobenzoate (prednisolone 21-(3-sulfobenzoate)) * Prednisolone palmitate * Prednisolone phosphate * Prednisolone piperidinoacetate * Prednisolone pivalate * Prednisolone steaglate (prednisolone stearoyl-glycolate) * Prednisolone stearoylglycolate * Prednisolone succinate (prednisolone hemisuccinate) * Prednisolone sulfate * Prednisolone tebutate (prednisolone ''tert''-butylacetate) * Prednisolone tetrahydrophthalate * Prednisolone valerate * Prednisolone valeroacetate


Prednisone esters

* Prednisone acetate * Prednisone palmitate * Prednisone succinate


Tixocortol esters

* Butixocort (tixocortol butyrate) * Butixocort propionate (tixocortol butyrate propionate) *
Tixocortol pivalate Tixocortol pivalate is a corticosteroid. It has anti-inflammatory properties similar to hydrocortisone. It is marketed under the brand name Pivalone. It is sometimes used in patch testing in atopic dermatitis. See also * Tixocortol Tixocor ...


Triamcinolone acetonide esters

*
Flupamesone Flupamesone (brand name Flutenal), also known as triamcinolone acetonide metembonate, is a synthetic glucocorticoid corticosteroid which is marketed in Spain. It is a dimer of a C21 ester of triamcinolone acetonide Triamcinolone acetonide, s ...
(triamcinolone acetonide metembonate) * Triamcinolone acetonide phosphate * Triamcinolone acetonide succinate (triamcinolone acetonide hemisuccinate) *
Triamcinolone benetonide Triamcinolone benetonide (brand names Alcorten, Benecorten, Tibicorten; also known as triamcinolone acetonide 21-(benzoyl-β-aminoisobutyrate) or TBI) is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormone ...
(triamcinolone acetonide 21-(benzoyl-β-aminoisobutyrate)) * Triamcinolone furetonide (triamcinolone acetonide 21-(2-benzofurancarboxylate)) * Triamcinolone hexacetonide (triamcinolone acetonide 21-(''tert''-butylacetate))


Esters of other synthetic corticosteroids

* Δ7-Prednisolone 21-acetate * Alclometasone dipropionate *
Amcinonide Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis. Amcinonide can also be classifie ...
(triamcinolone acetate cyclopentanonide) * Chloroprednisone acetate * Ciclometasone (a corticosteroid 21- -[(acetylamino)methylyclohexyl.html" ;"title="acetylamino)methyl.html" ;"title="-[(acetylamino)methyl">-[(acetylamino)methylyclohexyl">acetylamino)methyl.html" ;"title="-[(acetylamino)methyl">-[(acetylamino)methylyclohexylarboxylate ester) * Clobetasol propionate * Clobetasone butyrate * Cloprednol acetate * Cormetasone acetate * Cortivazol (a corticosteroid 21-acetate ester) * Cloticasone propionate * Deflazacort (a corticosteroid 21-acetate ester) * Deprodone propionate * Desonide phosphate * Desonide pivalate * Dichlorisone acetate * Dichlorisone diacetate * Diflorasone diacetate * Diflucortolone pivalate * Diflucortolone valerate * Difluprednate (difluoroprednisolone butyrate acetate) * Dimesone acetate * Drocinonide phosphate * Etiprednol dicloacetate * Fluazacort (a corticosteroid 21-acetate ester) *
Fludrocortisone acetate Fludrocortisone, sold under the brand name Florinef, among others, is a corticosteroid used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency. In adrenal insufficiency, it is generally taken together with hydroco ...
* Flumetasone acetate * Flumetasone pivalate * Flunisolide acetate * Fluorometholone acetate * Fluperolone acetate * Fluprednidene acetate *
Fluticasone furoate Fluticasone furoate, sold under the brand name Flonase Sensimist and formerly Veramyst, among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. It is also available as an inhaled ...
* Fluticasone propionate *
Formocortal Formocortal (INN), also known as fluoroformylone, is a corticosteroid used in dermatology and ophthalmology. It was introduced in around 1970 and is not known to be marketed . See also * Glucocorticoid Glucocorticoids (or, less commonly, g ...
(a corticosteroid 21-acetate ester) * Halopredone acetate (halopredone diacetate) * Icometasone enbutate * Isoflupredone acetate * Locicortolone dicibate * Loteprednol etabonate * Meclorisone dibutyrate * Meprednisone acetate * Meprednisone succinate (meprednisone hemisuccinate) * Mometasone furoate * Nicocortonide (a corticosteroid 21-isonicotinate ester) * Nicocortonide acetate * Paramethasone acetate * Paramethasone phosphate * Prebediolone acetate * Prednylidene diethylaminoacetate * Rofleponide palmitate * Ticabesone propionate * Timobesone acetate * Triamcinolone aminobenzal benzamidoisobutyrate * Triamcinolone diacetate *
Ulobetasol propionate Ulobetasol propionate, also known as halobetasol propionate and sold under the brand name Ultravate among others, is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal co ...
(halobetasol propionate)


See also

*
Steroid ester A steroid ester is an ester of a steroid. They include androgen esters, estrogen esters, progestogen esters, and corticosteroid esters. Steroid esters may be naturally occurring/endogenous like DHEA sulfate or synthetic like estradiol valerate. E ...
*
List of corticosteroid cyclic ketals This is a list of corticosteroid cyclic ketals, including cyclic ketals (cyclic acetals) of steroidal glucocorticoids and mineralocorticoids. They are almost all C16α,17α cyclic ketals of corticosteroids. One of the most widely used corticoster ...
*
List of corticosteroids This is a list of corticosteroids (glucocorticoids and mineralocorticoids) or derivatives of cortisol (hydrocortisone). Most esters of these corticosteroids are not included in this list; for esters, see here instead. The most common structural ...
* List of steroid esters


References

{{Mineralocorticoid receptor modulators Corticosteroid esters Corticosteroids Steroid esters Glucocorticoids Prodrugs