Leukotriene Receptor
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The leukotriene (LT) receptors are
G protein-coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
s that bind and are activated by the
leukotriene Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase. Leukotrienes ...
s. They include the following
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
s: * Leukotriene B4 receptors (BLTRs) – bind to and are activated by
LTB4 Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice. Biochemistry Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It is produced from leukocytes in respon ...
: ** BLT1 ( Leukotriene B4 receptor 1) – ** BLT2 ( Leukotriene B4 receptor 2) – *
Cysteinyl leukotriene receptor The cysteinyl leukotriene receptors (CysLTRs) include the following two receptors: * Cysteinyl leukotriene receptor 1 (CysLTR1) * Cysteinyl leukotriene receptor 2 (CysLTR2) The recently elucidated CysLTE, represented by GPR99/OXGR1, may const ...
s (CysLTRs) – bind to and are activated by
LTC4 Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast cells, its biosynthesis is orchestrated by translocation to the nuclear envelope along with c ...
,
LTD4 Leukotriene D4 (LTD4) is one of the leukotrienes. Its main function in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction and vasoconstriction. It also increases vascular permeability. LTD4 is released by bas ...
, and
LTE4 Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation. It is known to be produced by several types of white blood cells, including eosinophils, mast cells, tissue macrophages, and basophils, and recently was also found to be ...
: ** CysLT1 ( Cysteinyl leukotriene receptor 1) – ** CysLT2 ( Cysteinyl leukotriene receptor 2) – The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.


See also

*
Eicosanoid receptor Most of the eicosanoid receptors are integral membrane protein G protein-coupled receptors (GPCRs) that bind and respond to eicosanoid signaling molecules. Eicosanoids are rapidly metabolized to inactive products and therefore are short-lived. A ...
* Oxoeicosanoid receptor *
Prostaglandin receptor Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, (i.e. PGD2 ...
*
Thromboxane receptor The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the ''TBXA2R'' gene, The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid re ...


References


External links


IUPHAR GPCR Database – Leukotriene receptors
* Eicosanoids G protein-coupled receptors {{biochemistry-stub