Luke Lea may refer to:
*
Luke Lea (American politician, born 1783), U.S. Representative from Tennessee, 1833–1837
*
Luke Lea (American politician, born 1879), U.S. Senator from Tennessee, 1911–1917; founder of ''The Tennessean'' newspaper
* Luke Lea,
Commissioner of Indian Affairs 1850-1853
{{hndis, name=Lea, Luke