Locus suicide recombination (LSR) constitutes a variant form of
class switch recombination that eliminates all
immunoglobulin heavy chain constant genes.
It thus terminates immunoglobulin and
B-cell receptor
The B cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B cell receptor is composed of a membrane-bound immunoglobulin molecule and a signal transduction moiety. The former forms a type 1 transmembrane receptor protein, ...
(BCR) expression in B-lymphocytes and results in B-cell death since survival of such cells requires BCR expression. This process is initiated by the enzyme
activation-induced deaminase upon B-cell activation. LSR is thus one of the pathways that can result into
activation-induced cell death in the B-cell lineage.
[{{cite journal , last=Peron , first=S. , last2=Laffleur , first2=B. , last3=Denis-Lagache , first3=N. , last4=Cook-Moreau , first4=J. , last5=Tinguely , first5=A. , last6=Delpy , first6=L. , last7=Denizot , first7=Y. , last8=Pinaud , first8=E. , last9=Cogne , first9=M. , title=AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells , journal=Science , publisher=American Association for the Advancement of Science (AAAS) , volume=336 , issue=6083 , date=26 April 2012 , issn=0036-8075 , pmid=22539552 , doi=10.1126/science.1218692 , pages=931–934]
References
Biological concepts