Lochnericine is a major monoterpene indole alkaloid present in the roots of ''
Catharanthus roseus
''Catharanthus roseus'', commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae. It is native and endemic to M ...
''. It is also present in ''
Tabernaemontana divaricata
''Tabernaemontana divaricata'', commonly called pinwheel flower, crape jasmine, East India rosebay, and Nero's crown, is an evergreen shrub or small tree native to South Asia, Southeast Asia and China. In zones where it is not hardy it is grown a ...
''.
Chemistry
Synthesis
Lochnericine is formed from stereoselective epoxidation of carbons 6 and 7 of
tabersonine
Tabersonine is a terpene indole alkaloid found in the medicinal plant ''Catharanthus roseus'' and also in the genus Voacanga (both taxa belonging to the alkaloid-rich family Apocynaceae). Tabersonine is hydroxylated at the 16 position by the enzy ...
.
Derivatives
See also
*
Pericine
Pericine is one of a number of indole alkaloids found in the tree '' Picralima nitida'', commonly known as akuamma. As with some other alkaloids from this plant such as akuammine, pericine has been shown to bind to mu opioid receptors ''in vitro ...
*
Pervine
*
Tabersonine
Tabersonine is a terpene indole alkaloid found in the medicinal plant ''Catharanthus roseus'' and also in the genus Voacanga (both taxa belonging to the alkaloid-rich family Apocynaceae). Tabersonine is hydroxylated at the 16 position by the enzy ...
*
Vincamine
Vincamine is a monoterpenoid indole alkaloid found in the leaves of ''Vinca minor'' (lesser periwinkle), comprising about 25-65% of its indole alkaloids by weight. It can also be synthesized from related alkaloids.
Uses
Vincamine is sold in Eur ...
References
{{Reflist
Indole alkaloids
Alkaloids found in Apocynaceae