''Lobelia inflata'', also known as Indian tobacco or puke weed, is a species of ''

Lobelia ''Lobelia'' () is a genus of flowering plants comprising 415 species, with a subcosmopolitan distribution primarily in tropical to warm temperate regions of the world, a few species extending into cooler temperate regions.Huxley, A., ed. (1992 ...

'' native to eastern

North America North America is a continent in the Northern Hemisphere and almost entirely within the Western Hemisphere. It is bordered to the north by the Arctic Ocean, to the east by the Atlantic Ocean, to the southeast by South America and the Car ...

, from southeastern

Canada Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by tot ...

(

Nova Scotia Nova Scotia ( ; ; ) is one of the thirteen provinces and territories of Canada. It is one of the three Maritime provinces and one of the four Atlantic provinces. Nova Scotia is Latin for "New Scotland". Most of the population are native Eng ...

to southeast

Ontario Ontario ( ; ) is one of the thirteen provinces and territories of Canada.Ontario is located in the geographic eastern half of Canada, but it has historically and politically been considered to be part of Central Canada. Located in Central Ca ...

) south through the eastern

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...

Alabama (We dare defend our rights) , anthem = "Alabama (state song), Alabama" , image_map = Alabama in United States.svg , seat = Montgomery, Alabama, Montgomery , LargestCity = Huntsville, Alabama, Huntsville , LargestCounty = Baldwin County, Al ...

and west to

Kansas Kansas () is a state in the Midwestern United States. Its capital is Topeka, and its largest city is Wichita. Kansas is a landlocked state bordered by Nebraska to the north; Missouri to the east; Oklahoma to the south; and Colorado to the ...

Description

''Lobelia inflata'' is an

annual Annual may refer to: * Annual publication, periodical publications appearing regularly once per year **Yearbook ** Literary annual * Annual plant * Annual report * Annual giving * Annual, Morocco, a settlement in northeastern Morocco * Annuals (b ...

biennial Biennial means (an event) lasting for two years or occurring every two years. The related term biennium is used in reference to a period of two years. In particular, it can refer to: * Biennial plant, a plant which blooms in its second year and th ...

herbaceous plant Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of t ...

growing to tall, with stems covered in tiny hairs. Its

leaves A leaf (plural, : leaves) is any of the principal appendages of a vascular plant plant stem, stem, usually borne laterally aboveground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", wh ...

are usually about long, and are

ovate Ovate may refer to: *Ovate (egg-shaped) leaves, tepals, or other botanical parts *Ovate, a type of prehistoric stone hand axe *Ovates, one of three ranks of membership in the Welsh Gorsedd *Vates In modern English, the nouns vates () and ovat ...

and toothed. They are alternately arranged. It has violet flowers that are tinted yellow on the inside, and usually appear in mid-summer and continue to bloom into fall.Caldecott, T. ''Western Materia Medica''
''Lobelia inflata'' (pdf file)
/ref> The seedcases are small, brown, dehiscent, and papery.

Propagation

Propagation is usually accomplished by cuttings or seed. Seeds are sown in containers in mid spring or mid fall. The seeds take about 2 weeks to

germinate Germination is the process by which an organism grows from a seed or spore. The term is applied to the sprouting of a seedling from a seed of an angiosperm or gymnosperm, the growth of a sporeling from a spore, such as the spores of fungi, fer ...

Traditional uses and adverse effects

''Lobelia inflata'' has a long use as a

medicinal plant Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesize hundreds of chemical compounds for various functions, including Plant defense against her ...

as an

entheogen Entheogens are psychoactive substances that induce alterations in perception, mood (psychology), mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclop ...

ic,

emetic Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Vomiting can be the result of ailments like food poisoning, gastroenteri ...

, and skin or

respiratory The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies grea ...

aid. University of Michigan at Dearborn: Native American Ethnobotany of ''Lobelia inflata''
/ref> Native Americans used it for respiratory and muscle disorders, as a

purgative Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubri ...

, and as a ceremonial medicine. The leaves were chewed and smoked. The plant was used as a traditional medicinal plant by the

Cherokee The Cherokee (; chr, ᎠᏂᏴᏫᏯᎢ, translit=Aniyvwiyaʔi or Anigiduwagi, or chr, ᏣᎳᎩ, links=no, translit=Tsalagi) are one of the indigenous peoples of the Southeastern Woodlands of the United States. Prior to the 18th century, t ...

Iroquois The Iroquois ( or ), officially the Haudenosaunee ( meaning "people of the longhouse"), are an Iroquoian-speaking confederacy of First Nations peoples in northeast North America/ Turtle Island. They were known during the colonial years to ...

Penobscot The Penobscot (Abenaki: ''Pαnawάhpskewi'') are an Indigenous people in North America from the Northeastern Woodlands region. They are organized as a federally recognized tribe in Maine and as a First Nations band government in the Atlantic pr ...

, and other indigenous peoples. The foliage was burned by the Cherokee as a natural

insecticide Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to b ...

, to smoke out

gnat A gnat () is any of many species of tiny flying insects in the dipterid suborder Nematocera, especially those in the families Mycetophilidae, Anisopodidae and Sciaridae. They can be both biting and non-biting. Most often they fly in large num ...

s. Although it may be used medicinally, consuming lobelia causes

adverse effect An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. The term complica ...

s, which may include sweating,

nausea Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. While not painful, it can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the ...

, vomiting,

diarrhea Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin wi ...

, tremors, rapid heartbeat, mental confusion, convulsions,

hypothermia Hypothermia is defined as a body core temperature below in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe h ...

coma A coma is a deep state of prolonged unconsciousness in which a person cannot be awakened, fails to respond normally to painful stimuli, light, or sound, lacks a normal wake-sleep cycle and does not initiate voluntary actions. Coma patients exhi ...

, or possibly death. The root is toxic and can be fatal if eaten.

Chemical constituents

''Lobelia inflata'' contains multiple

alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...

compounds, including

lobeline Lobeline is a pyridine alkaloid found in a variety of plants, particularly those in the genus ''Lobelia'', including Indian tobacco (''Lobelia inflata''), Devil's tobacco (''Lobelia tupa''), great lobelia (''Lobelia siphilitica''), ''Lobelia chin ...

, norlobelanine,

lobelanidine Lobelanidine is a chemical analog of lobeline Lobeline is a pyridine alkaloid found in a variety of plants, particularly those in the genus ''Lobelia'', including Indian tobacco ('' Lobelia inflata''), Devil's tobacco ('' Lobelia tupa''), great ...

, and radicamine, among other compounds, such as

flavonoid Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids ...

terpene Terpenes () are a class of natural products consisting of compounds with the formula (C5H8)n for n > 1. Comprising more than 30,000 compounds, these unsaturated hydrocarbons are produced predominantly by plants, particularly conifers. Terpenes ar ...

alkyne \ce \ce Acetylene \ce \ce \ce Propyne \ce \ce \ce \ce 1-Butyne In organic chemistry, an alkyne is an unsaturated hydrocarbon containing at least one carbon—carbon triple bond. The simplest acyclic alkynes with only one triple bond and n ...

s, and

coumarin Coumarin () or 2''H''-chromen-2-one is an aromatic organic chemical compound with formula . Its molecule can be described as a benzene molecule with two adjacent hydrogen atoms replaced by a lactone-like chain , forming a second six-membered h ...

s. Lobeline concentration is highest in the seeds.

References

External links

USDA Plants Profile for ''Lobelia inflata'' (Indian-tobacco)

Lobelia inflata - Plants For A Future database report

{{Taxonbar, from=Q1661351 inflata Flora of Eastern Canada Flora of the Northeastern United States Flora of the North-Central United States Flora of the Southeastern United States Flora of the Appalachian Mountains Flora of the Great Lakes region (North America) Entheogens Plants used in traditional Native American medicine Plants described in 1753 Taxa named by Carl Linnaeus Flora without expected TNC conservation status