Lipoblastoma is a type of rare,
subcutaneous,
benign
Malignancy () is the tendency of a medical condition to become progressively worse.
Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous benign tumor, ''benign'' tumor in that a malign ...
, fatty
tumor
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...
,
found in infants, and children, more common in males with tendency of local recurrence. Local recurrence can happen in up to 80% of incompletely resected tumours. Therefore, complete surgical resection is required to prevent recurrence. It arises from embyronic
white fat
White is the lightest color and is achromatic (having no hue). It is the color of objects such as snow, chalk, and milk, and is the opposite of black. White objects fully reflect and scatter all the visible wavelengths of light. White on ...
that is rapidly enlarging. Most common locations are at the trunk and extremities.
Types include:
*
Benign lipoblastomatosis, a tumor, also known as an
embryonic lipoma, which usually occurs in children under three years old. This is the tumor of
brown fat
Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). Brown adipose tissue is found in almost all mammals.
Classification of brown fat refers to two distinct cell populations with si ...
cells.
*
Myxoid lipoblastoma
Myxoid lipoblastoma is a cutaneous condition characterized by excess mucin. It resembles myxoid liposarcoma
A myxoid liposarcoma is a malignant adipose tissue neoplasm of myxoid appearance histologically.
Myxoid liposarcomas are the second-mos ...
, a cutaneous condition characterized by excess
mucin
Mucins () are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most ...
Specimen
Macroscopic
Grossly, it has a pale yellow, myxoid cut surface with small cystic foci.
Microscopic
It has lobules consists of immature adipose tissue separated by fibrous septa and
lipoblast
A lipoblast is a precursor cell for an adipocyte.
Alternate terms include adipoblast and preadipocyte.
Early stages are almost indistinguishable from fibroblasts.
File:Lipoblasts and lipocytes.jpg, Lipoblasts (white arrow) and lipocytes (black ...
s at different stages of maturation, without
atypia
Atypia (from Greek, ''a'' + ''typos'', without type; a condition of being irregular or nonstandard) is a histopathologic term for a structural abnormality in a cell, i.e. it is used to describe atypical cells.
Atypia can be caused by an infection ...
or
mitosis
In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is mainta ...
. Plexiform capillary network and mature adipose tissue are seen at the central part of the lobule.
See also
*
Lipoblast
A lipoblast is a precursor cell for an adipocyte.
Alternate terms include adipoblast and preadipocyte.
Early stages are almost indistinguishable from fibroblasts.
File:Lipoblasts and lipocytes.jpg, Lipoblasts (white arrow) and lipocytes (black ...
*
Lipoma
A lipoma is a benign tumor made of fat tissue. They are generally soft to the touch, movable, and painless. They usually occur just under the skin, but occasionally may be deeper. Most are less than in size. Common locations include upper back, ...
References
Dermal and subcutaneous growths
Soft tissue disorders
Benign neoplasms
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