Limbic system-associated membrane protein (LAMP) 64- to 68-

kDa The dalton or unified atomic mass unit (symbols: Da or u) is a non-SI unit of mass widely used in physics and chemistry. It is defined as of the mass of an unbound neutral atom of carbon-12 in its nuclear and electronic ground state and at re ...

heavily

glycosylated Glycosylation is the reaction in which a carbohydrate (or 'glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate. In biology (but not alw ...

protein found in

neurons A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. N ...

, specifically it is distributed in cortical and subcortical regions of the

limbic system The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain.Schacter, Daniel L. 2012. ''Ps ...

. LAMP protein is expressed on the surface of somata and proximal dendrites of neurons where it integrates via glycosyl-phosphatidyl-inositol (GPI) anchor. Despite the name, LAMP is not expressed only in the limbic-associated areas, but also less intensely in the midbrain and hindbrain regions.

References

Membrane proteins Neurons Limbic system {{membrane-protein-stub