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Liquorice (
British English British English (BrE, en-GB, or BE) is, according to Lexico, Oxford Dictionaries, "English language, English as used in Great Britain, as distinct from that used elsewhere". More narrowly, it can refer specifically to the English language in ...
) or licorice (
American English American English, sometimes called United States English or U.S. English, is the set of variety (linguistics), varieties of the English language native to the United States. English is the Languages of the United States, most widely spoken lan ...
) ( ; also ) is the
common name In biology, a common name of a taxon or organism (also known as a vernacular name, English name, colloquial name, country name, popular name, or farmer's name) is a name that is based on the normal language of everyday life; and is often contrast ...
of ''Glycyrrhiza glabra'', a
flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (), commonly called angiosperms. The term "angiosperm" is derived from the Greek words ('container, vessel') and ('seed'), and refers to those plants th ...
of the bean family
Fabaceae The Fabaceae or Leguminosae,International Code of Nomenc ...
, from the root of which a sweet, aromatic flavouring can be extracted. The liquorice plant is an
herbaceous Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of t ...
perennial A perennial plant or simply perennial is a plant that lives more than two years. The term ('' per-'' + '' -ennial'', "through the years") is often used to differentiate a plant from shorter-lived annuals and biennials. The term is also wide ...
legume A legume () is a plant in the family Fabaceae (or Leguminosae), or the fruit or seed of such a plant. When used as a dry grain, the seed is also called a pulse. Legumes are grown agriculturally, primarily for human consumption, for livestock f ...
native to
Western Asia Western Asia, West Asia, or Southwest Asia, is the westernmost subregion of the larger geographical region of Asia, as defined by some academics, UN bodies and other institutions. It is almost entirely a part of the Middle East, and includes Ana ...
,
North Africa North Africa, or Northern Africa is a region encompassing the northern portion of the African continent. There is no singularly accepted scope for the region, and it is sometimes defined as stretching from the Atlantic shores of Mauritania in ...
, and
Southern Europe Southern Europe is the southern regions of Europe, region of Europe. It is also known as Mediterranean Europe, as its geography is essentially marked by the Mediterranean Sea. Definitions of Southern Europe include some or all of these countrie ...
. Botanically, it is not closely related to
anise Anise (; '), also called aniseed or rarely anix is a flowering plant in the family Apiaceae native to Eurasia. The flavor and aroma of its seeds have similarities with some other spices and herbs, such as star anise, fennel, licorice, and ta ...
or
fennel Fennel (''Foeniculum vulgare'') is a flowering plant species in the carrot family. It is a hardy, perennial herb with yellow flowers and feathery leaves. It is indigenous to the shores of the Mediterranean but has become widely naturalized ...
, which are sources of similar flavouring compounds. (Another such source,
star anise ''Illicium verum'' is a medium-sized evergreen tree native to northeast Vietnam and southwest China. A spice commonly called star anise, staranise, star anise seed, star aniseed, star of anise, Chinese star anise, or badian that closely resembl ...
, is even more distantly related from anise and fennel than liquorice, despite its similar common name.) Liquorice is used as a flavouring in candies and
tobacco Tobacco is the common name of several plants in the genus '' Nicotiana'' of the family Solanaceae, and the general term for any product prepared from the cured leaves of these plants. More than 70 species of tobacco are known, but the ...
, particularly in some European and West Asian countries. Liquorice extracts have been used in
herbalism Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. With worldwide research into pharmacology, some herbal medicines have been translated into modern reme ...
and
traditional medicine Traditional medicine (also known as indigenous medicine or folk medicine) comprises medical aspects of traditional knowledge that developed over generations within the folk beliefs of various societies, including indigenous peoples, before the ...
. Excessive consumption of liquorice (more than per day of pure
glycyrrhizinic acid Glycyrrhizin (or glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of ''Glycyrrhiza glabra'' (liquorice) root. Structurally, it is a saponin used as an emulsifier and gel-forming agent in foodstuffs and cosmetics. ...
, a liquorice component) may result in adverse effects, and overconsumption should be suspected clinically in patients presenting with otherwise unexplained
hypokalemia Hypokalemia is a low level of potassium (K+) in the blood serum. Mild low potassium does not typically cause symptoms. Symptoms may include feeling tired, leg cramps, weakness, and constipation. Low potassium also increases the risk of an abno ...
and muscle weakness. In at least one case, death has been attributed to excessive liquorice consumption.


Etymology

The word ''
liquorice Liquorice (British English) or licorice (American English) ( ; also ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring can be extracted. The liqu ...
'', or ''
licorice Liquorice (British English) or licorice (American English) ( ; also ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring can be extracted. The liq ...
'', is derived via the
Anglo-French Anglo-French (or sometimes Franco-British) may refer to: *France–United Kingdom relations *Anglo-Norman language or its decendants, varieties of French used in medieval England *Anglo-Français and Français (hound), an ancient type of hunting d ...
, from
Late Latin Late Latin ( la, Latinitas serior) is the scholarly name for the form of Literary Latin of late antiquity.Roberts (1996), p. 537. English dictionary definitions of Late Latin date this period from the , and continuing into the 7th century in t ...
, itself ultimately derived from Greek grc, γλυκύρριζα, glykyrrhiza, label=none (the
Modern Greek Modern Greek (, , or , ''Kiní Neoellinikí Glóssa''), generally referred to by speakers simply as Greek (, ), refers collectively to the dialects of the Greek language spoken in the modern era, including the official standardized form of the ...
spelling of the genus is el, γλυκόριζα, glykoriza, label=none) literally meaning 'sweet root' and referring to ''Glycyrrhiza glabra''. The Late Latin form is a corruption of the older form , as attested in
Pliny Pliny may refer to: People * Pliny the Elder (23–79 CE), ancient Roman nobleman, scientist, historian, and author of ''Naturalis Historia'' (''Pliny's Natural History'') * Pliny the Younger (died 113), ancient Roman statesman, orator, w ...
's latinization of the Greek. The latter gives the plant's binomial name with ''glabra'' meaning 'smooth' and referring to the plant's smooth husks; the former came to being via the influence of , 'to become fluid', reflecting the method of extraction of the sweet stuff from the roots. , its English common name is spelled 'liquorice' in most of the
Commonwealth A commonwealth is a traditional English term for a political community founded for the common good. Historically, it has been synonymous with "republic". The noun "commonwealth", meaning "public welfare, general good or advantage", dates from the ...
, but 'licorice' in the United States.


Description

Liquorice is a
herbaceous Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of t ...
perennial A perennial plant or simply perennial is a plant that lives more than two years. The term ('' per-'' + '' -ennial'', "through the years") is often used to differentiate a plant from shorter-lived annuals and biennials. The term is also wide ...
, growing to in height, with
pinnate Pinnation (also called pennation) is the arrangement of feather-like or multi-divided features arising from both sides of a common axis. Pinnation occurs in biological morphology, in crystals, such as some forms of ice or metal crystals, and in ...
leaves A leaf (plural, : leaves) is any of the principal appendages of a vascular plant plant stem, stem, usually borne laterally aboveground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", wh ...
about long, with 9–17 leaflets. The
flower A flower, sometimes known as a bloom or blossom, is the reproductive structure found in flowering plants (plants of the division Angiospermae). The biological function of a flower is to facilitate reproduction, usually by providing a mechani ...
s are long, purple to pale whitish blue, produced in a loose
inflorescence An inflorescence is a group or cluster of flowers arranged on a stem that is composed of a main branch or a complicated arrangement of branches. Morphologically, it is the modified part of the shoot of seed plants where flowers are formed o ...
. The
fruit In botany, a fruit is the seed-bearing structure in flowering plants that is formed from the ovary after flowering. Fruits are the means by which flowering plants (also known as angiosperms) disseminate their seeds. Edible fruits in particu ...
is an oblong pod, long, containing several
seed A seed is an embryonic plant enclosed in a protective outer covering, along with a food reserve. The formation of the seed is a part of the process of reproduction in seed plants, the spermatophytes, including the gymnosperm and angiospe ...
s.Huxley, A., ed. (1992). ''New RHS Dictionary of Gardening''. The roots are
stoloniferous In biology, stolons (from Latin '' stolō'', genitive ''stolōnis'' – "branch"), also known as runners, are horizontal connections between organisms. They may be part of the organism, or of its skeleton; typically, animal stolons are external ...
.


Chemistry

The scent of liquorice root comes from a complex and variable combination of compounds, of which
anethole Anethole (also known as anise camphor) is an organic compound that is widely used as a flavoring substance. It is a derivative of phenylpropene, a type of aromatic compound that occurs widely in nature, in essential oils. It is in the class of p ...
is up to 3% of total volatiles. Much of the
sweetness Sweetness is a Taste#Basic tastes, basic taste most commonly Perception, perceived when eating foods rich in sugars. Sweet tastes are generally regarded as pleasure, pleasurable. In addition to sugars like sucrose, many other chemical compounds ...
in liquorice comes from
glycyrrhizin Glycyrrhizin (or glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of ''Glycyrrhiza glabra'' ( liquorice) root. Structurally, it is a saponin used as an emulsifier and gel-forming agent in foodstuffs and cosmet ...
, which has 30–50 times the sweetness of
sugar Sugar is the generic name for sweet-tasting, soluble carbohydrates, many of which are used in food. Simple sugars, also called monosaccharides, include glucose, fructose, and galactose. Compound sugars, also called disaccharides or double ...
. The sweetness is different from sugar, being less instant, tart, and lasting longer. The isoflavene glabrene and the isoflavane glabridin, found in the roots of liquorice, are
phytoestrogen A phytoestrogen is a plant-derived xenoestrogen (see estrogen) not generated within the endocrine system, but consumed by eating plants or manufactured foods. Also called a "dietary estrogen", it is a diverse group of naturally occurring nonstero ...
s.


Cultivation and uses

Liquorice grows best in well-drained soils in deep valleys with full sun. It is harvested in the autumn two to three years after planting. Countries producing liquorice include India, Iran, Italy, Afghanistan, China, Pakistan ( in
Urdu Urdu (;"Urdu"
''
M & F Worldwide Corp., Annual Report on Form 10-K for the Year Ended December 31, 2010
In India, liquorice is called () in the region of
Maharashtra Maharashtra (; , abbr. MH or Maha) is a states and union territories of India, state in the western India, western peninsular region of India occupying a substantial portion of the Deccan Plateau. Maharashtra is the List of states and union te ...
. In 2019, the world market for liquorice extract was 191 million, with the largest exporters led by
France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...
,
Uzbekistan Uzbekistan (, ; uz, Ozbekiston, italic=yes / , ; russian: Узбекистан), officially the Republic of Uzbekistan ( uz, Ozbekiston Respublikasi, italic=yes / ; russian: Республика Узбекистан), is a doubly landlocked cou ...
, China, and
Iran Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...
, each providing 10–14% of the total.


Tobacco

Liquorice is used as a flavouring agent for
tobacco Tobacco is the common name of several plants in the genus '' Nicotiana'' of the family Solanaceae, and the general term for any product prepared from the cured leaves of these plants. More than 70 species of tobacco are known, but the ...
, for flavour-enhancing and moistening agents in the manufacture of American blend
cigarette A cigarette is a narrow cylinder containing a combustible material, typically tobacco, that is rolled into thin paper for smoking. The cigarette is ignited at one end, causing it to smolder; the resulting smoke is orally inhaled via the opp ...
s, moist
snuff Snuff may refer to: Tobacco * Snuff (tobacco), fine-ground tobacco, sniffed into the nose ** Moist snuff or dipping tobacco ** Creamy snuff, an Indian tobacco paste Media and entertainment * Snuff film, a type of film that shows a murder Literat ...
,
chewing tobacco Chewing tobacco is a type of smokeless tobacco product that is placed between the cheek and lower gum to draw out its flavor. Some users chew it, others do not. It consists of coarsely chopped aged tobacco that is flavored and often sweetened; ...
, and
pipe tobacco A tobacco pipe, often called simply a pipe, is a device specifically made to smoke tobacco. It comprises a chamber (the bowl (smoking), bowl) for the tobacco from which a thin hollow stem (shank) emerges, ending in a mouthpiece. Pipes can rang ...
. Liquorice provides tobacco products with a natural sweetness and a distinctive flavour that blends readily with the natural and imitation flavouring components employed in the tobacco industry. Liquorice can also be added to cigarette rolling papers. , the US
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
banned the use of any "characterizing flavors" other than menthol from cigarettes, but not other manufactured tobacco products.


Food and confectionery

Liquorice flavour is found in a wide variety of candies or sweets. In most of these candies, the taste is reinforced by
aniseed Anise (; '), also called aniseed or rarely anix is a flowering plant in the family Apiaceae native to Eurasia. The flavor and aroma of its seeds have similarities with some other spices and herbs, such as star anise, fennel, licorice, and tar ...
oil so the actual content of liquorice is very low. Liquorice confections are primarily purchased by consumers in Europe, but are also popular in other countries such as Australia and New Zealand. In the Netherlands, liquorice confectionery (''drop'') is one of the most popular forms of sweets. It is sold in many forms. Mixing it with
mint MiNT is Now TOS (MiNT) is a free software alternative operating system kernel for the Atari ST system and its successors. It is a multi-tasking alternative to TOS and MagiC. Together with the free system components fVDI device drivers, XaAES g ...
,
menthol Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. It is a waxy, clear or white crystalline substance, which is solid at room temperature and ...
,
aniseed Anise (; '), also called aniseed or rarely anix is a flowering plant in the family Apiaceae native to Eurasia. The flavor and aroma of its seeds have similarities with some other spices and herbs, such as star anise, fennel, licorice, and tar ...
, or
laurel Laurel may refer to: Plants * Lauraceae, the laurel family * Laurel (plant), including a list of trees and plants known as laurel People * Laurel (given name), people with the given name * Laurel (surname), people with the surname * Laurel (mus ...
is quite popular. Mixing it with ammonium chloride () is also popular as it is in Finland. A popular example of salmiak liquorice in the Netherlands is known as ('
salty liquorice Salty liquorice, salmiak liquorice or salmiac liquorice, is a variety of liquorice flavoured with the ingredient "salmiak salt" ( sal ammoniac; ammonium chloride), and is a common confection found in the Nordic countries, Benelux, and northe ...
'), but it contains very little if any common salt (sodium chloride). Strong, salty sweets are also popular in
Nordic countries The Nordic countries (also known as the Nordics or ''Norden''; literal translation, lit. 'the North') are a geographical and cultural region in Northern Europe and the Atlantic Ocean, North Atlantic. It includes the sovereign states of Denmar ...
where liquorice flavoured alcohols are also popular, particularly in Denmark and Finland. Dried sticks of the liquorice root are also a traditional confectionery in their own right in the Netherlands as were they once in Britain although their popularity has waned in recent decades. They were sold simply as sticks of ('sweet wood') to chew on as a candy. Through chewing and suckling, the intensely sweet flavour is released. The sweetness is 30 to 50 times as strong as sucrose, without causing damage to teeth. Since about the 1970s, has become rarer and been replaced by easier to consume candies (including 'drop').
Pontefract Pontefract is a historic market town in the Metropolitan Borough of Wakefield in West Yorkshire, England, east of Wakefield and south of Castleford. Historically part of the West Riding of Yorkshire, it is one of the towns in the City of Wake ...
in
Yorkshire Yorkshire ( ; abbreviated Yorks), formally known as the County of York, is a Historic counties of England, historic county in northern England and by far the largest in the United Kingdom. Because of its large area in comparison with other Eng ...
, England, is where liquorice mixed with sugar began to be used as a sweet in the contemporary way.
Pontefract cake Pontefract cakes (also known as Pomfret cakes and Pomfrey cakes) are a type of small, roughly circular black sweet measuring approximately 3/4" (2 cm) wide and 1/5" (4mm) thick, made of liquorice, originally manufactured in the Yorkshire ...
s were originally made there. In Cumbria, County Durham, Yorkshire and Lancashire, it is colloquially known as 'Spanish', supposedly because Spanish monks grew liquorice root at
Rievaulx Abbey Rievaulx Abbey was a Cistercian abbey in Rievaulx, near Helmsley, in the North York Moors National Park, North Yorkshire, England. It was one of the great abbeys in England until it was seized in 1538 under Henry VIII during the Dissoluti ...
near
Thirsk Thirsk is a market town and civil parish in the Hambleton district of North Yorkshire, England known for its racecourse; quirky yarnbomber displays, and depiction as local author James Herriot's fictional Darrowby. History Archeological fin ...
. In Italy, Spain and France, liquorice is popular in its natural form. The root of the plant is simply dug up, washed, dried, and chewed as a mouth freshener. Throughout Italy, unsweetened liquorice is consumed in the form of small black pieces made only from 100% pure liquorice extract. In
Calabria , population_note = , population_blank1_title = , population_blank1 = , demographics_type1 = , demographics1_footnotes = , demographics1_title1 = , demographics1_info1 = , demographics1_title2 ...
a popular
liqueur A liqueur (; ; ) is an alcoholic drink composed of spirits (often rectified spirit) and additional flavorings such as sugar, fruits, herbs, and spices. Often served with or after dessert, they are typically heavily sweetened and un-aged beyond ...
is made from pure liquorice extract. Liquorice is used in Syria and Egypt, and only in Diyarbakır in Turkey, where it is sold as a drink, in shops as well as street vendors.


Research

Properties of
glycyrrhizin Glycyrrhizin (or glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of ''Glycyrrhiza glabra'' ( liquorice) root. Structurally, it is a saponin used as an emulsifier and gel-forming agent in foodstuffs and cosmet ...
are under preliminary research, such as for
hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, a ...
or
topical A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes ...
treatment of
psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by raised areas of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complete ...
, but the low quality of studies prevents conclusions about efficacy and safety.


Traditional medicine

In
traditional Chinese medicine Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action ...
, a related species ''G. uralensis'' (often translated as "liquorice") is known as (), and is believed to "harmonize" the ingredients in a formula. Liquorice has been used in
Ayurveda Ayurveda () is an alternative medicine system with historical roots in the Indian subcontinent. The theory and practice of Ayurveda is pseudoscientific. Ayurveda is heavily practiced in India and Nepal, where around 80% of the population repo ...
in the belief it may treat various diseases, although there is no high-quality
clinical research Clinical research is a branch of healthcare science that determines the safety and effectiveness ( efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatm ...
to indicate it is safe or effective for any medicinal purpose. The European Medical Agency added liquorice to their list of herbal medicine.


Toxicity

The major dose-limiting toxicities of liquorice are
corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involv ...
in nature, because of the inhibitory effect that its chief active constituents, glycyrrhizin and
enoxolone Enoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is u ...
, have on
cortisol Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone. It is produced in many animals, mainly by the ''zona fasciculata'' of the adrenal cortex in the adrenal gland ...
degradation, and include
edema Edema, also spelled oedema, and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's Tissue (biology), tissue. Most commonly, the legs or arms are affected. Symptoms may include skin which feels t ...
,
hypokalaemia Hypokalemia is a low level of potassium (K+) in the blood serum. Mild low potassium does not typically cause symptoms. Symptoms may include feeling tired, leg cramps, weakness, and constipation. Low potassium also increases the risk of an abnor ...
, weight gain or loss, and
hypertension Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high bl ...
. The United States
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
believes that foods containing liquorice and its derivatives (including glycyrrhizin) are safe if not consumed excessively. Other jurisdictions have suggested no more than of glycyrrhizin per day, the equivalent of about of liquorice confectionery. Liquorice should not be eaten or used during pregnancy.


Fungicide

The
essential oil An essential oil is a concentrated hydrophobic liquid containing volatile (easily evaporated at normal temperatures) chemical compounds from plants. Essential oils are also known as volatile oils, ethereal oils, aetheroleum, or simply as the o ...
s inhibit the growth of ''
Aspergillus flavus ''Aspergillus flavus'' is a saprotrophic and pathogenic fungus with a cosmopolitan distribution. It is best known for its colonization of cereal grains, legumes, and tree nuts. Postharvest rot typically develops during harvest, storage, and/or t ...
''.


Liquorice poisoning

Liquorice is an extract from the ''Glycyrrhiza glabra'' plant which contains
glycyrrhizic acid Glycyrrhizin (or glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of ''Glycyrrhiza glabra'' (liquorice) root. Structurally, it is a saponin used as an emulsifier and gel-forming agent in foodstuffs and cosmetics. ...
, or GZA. GZA molecules are composed of one molecule of
glycyrrhetinic acid Enoxolone (International Nonproprietary Name, INN, British Approved Name, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic ac ...
and two molecules of
glucuronic acid Glucuronic acid (from Greek γλεῦκος "''wine, must''" and οὖρον "''urine''") is a uronic acid that was first isolated from urine (hence the name). It is found in many gums such as gum arabic (c. 18%), xanthan, and kombucha tea and ...
. The extracts from the root of the plant can be referred to as liquorice, sweet root, and glycyrrhiza extract. ''G. glabra'' grows in Europe and Western Asia. When administered orally, the product of glycyrrhetinic acid is found in human urine whereas GZA is not. This shows that glycyrrhetic acid is absorbed and metabolized in the intestines in humans. GZA is hydrolyzed to glycyrrhetic acid in the intestines by bacteria. For thousands of years, ''G. glabra'' has been used for medicinal purposes including indigestion and stomach inflammation. Some other medicinal uses are cough suppression, ulcer treatment, and as a laxative. Salts of GZA can also be used in many products as sweeteners and aromatizers. The major (roughly 90%) use of liquorice is in the
tobacco industry The tobacco industry comprises those persons and companies who are engaged in the growth, preparation for sale, shipment, advertisement, and distribution of tobacco and tobacco-related products. It is a global industry; tobacco can grow in any ...
. The rest is split evenly between food and pharmaceutics, at 5% of usage each. Liquorice extract is often found in many sweets and candies, some drugs, and beverages like root beer. It can also be used in chewing gum, tobacco products like snuff, and toothpaste. A high intake of liquorice can have many toxic effects. Hyper-mineralocorticosteroid syndrome can occur when the body retains sodium, loses potassium altering biochemical and hormonal activities. Some of these activities include lower
aldosterone Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. It plays a c ...
level, decline of the renin-angiotensin system and increased levels of the atrial natriuretic hormone in order to compensate the variations in homoeostasis. Some other symptoms of toxicity include
electrolyte imbalance Electrolyte imbalance, or water-electrolyte imbalance, is an abnormality in the concentration of electrolytes in the body. Electrolytes play a vital role in maintaining homeostasis in the body. They help to regulate heart and neurological function, ...
,
edema Edema, also spelled oedema, and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's Tissue (biology), tissue. Most commonly, the legs or arms are affected. Symptoms may include skin which feels t ...
, increased
blood pressure Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" r ...
, weight gain, heart problems, and weakness. Symptoms depend on the severity of toxicity. Some other complaints include fatigue,
shortness of breath Shortness of breath (SOB), also medically known as dyspnea (in AmE) or dyspnoea (in BrE), is an uncomfortable feeling of not being able to breathe well enough. The American Thoracic Society defines it as "a subjective experience of breathing disc ...
,
kidney failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...
, and paralysis. In 2020, physicians reported a case of a man who died of cardiac arrest as a result of drastically low potassium levels. He had been eating a bag of black licorice a day for three weeks previously. Most adverse effects of liquorice poisoning are attributed to the mineralocorticoid effects of GZA. Depending on the dose and intake of liquorice, serious problems and even hospitalization can occur. People with previously existing heart or kidney problems may be more susceptible to GZA and liquorice poisoning. It is important to monitor the amount of liquorice consumed in order to prevent toxicity. It is difficult to determine a safe level, because the effects are affected by a variety of factors and vary from person to person. In the most sensitive individuals, daily intake of about GZA can cause problems. This is equivalent to liquorice sweets. However, most people can consume up to before experiencing symptoms, which would be about liquorice sweets. A rule of thumb is that a normal healthy person can consume GZA a day.


Gallery

Image:Réglisse(racine).JPG, Liquorice root with bark File:Glycyrrhiza glabra inflorescence.jpg, Inflorescence of ''G. glabra'' File:2013.02-402-022aP Liquorice products tue05feb2013.jpg, Various liquorice products Image:Liquorice4.jpg, Different flavoured liquorice sticks File:Gardenology.org-IMG 2804 rbgs11jan.jpg, Foliage Image:Glycyrrhiza glabra - Köhler–s Medizinal-Pflanzen-207.jpg, ''G. glabra'' from Koehler's ''Medicinal-Plants''


References


External links

*
''Glycyrrhiza glabra'' (licorice)
Kew plant profile

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Chemical & Engineering News ''Chemical & Engineering News'' (''C&EN'') is a weekly news magazine published by the American Chemical Society, providing professional and technical news and analysis in the fields of chemistry and chemical engineering. 11β-Hydroxysteroid dehydrogenase inhibitors Glycyrrhiza Spices Sugar substitutes Medicinal plants Plants used in traditional Chinese medicine Monoamine oxidase inhibitors Demulcents Plants used in Ayurveda Plants described in 1753 Indian spices