Levocetirizine, sold under the brand name Xyzal, among others, is a second-generation antihistamine used for the treatment of allergic rhinitis (hay fever) and long-term hives of unclear cause. It is less sedating than older antihistamines. It is taken by mouth. Common side effects include sleepiness, dry mouth, cough, vomiting, and diarrhea. Use in pregnancy appears safe but has not been well studied and use when

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is of unclear safety. It is classified as a second-generation antihistamine and works by blocking histamine H₁-receptors. Levocetirizine was approved for medical use in the United States in 2007, and is available as a generic medication. In 2022, it was the 152nd most commonly prescribed medication in the United States, with more than 3million prescriptions.

Medical uses

Levocetirizine is used for allergic rhinitis. This includes allergy symptoms such as watery eyes, runny nose, sneezing, hives, and itching.

Side effects

Levocetirizine is referred to as a non-sedating antihistamine as it does not enter the brain in significant amounts and is therefore unlikely to cause drowsiness. Cardiac safety with repolarization may be better than some other antihistamines, as levocetirizine does not significantly prolong the QT interval in healthy individuals. However, some people may still experience some slight sleepiness, headache, mouth dryness, lightheadedness, vision problems (mainly blurred vision), palpitations and

fatigue Fatigue is a state of tiredness (which is not sleepiness), exhaustion or loss of energy. It is a signs and symptoms, symptom of any of various diseases; it is not a disease in itself. Fatigue (in the medical sense) is sometimes associated wit ...

. On 16 May 2025, the U.S. Food and Drug Administration (FDA) issued a Drug Safety Communication regarding a rare but severe itching, known as pruritus, that can occur after discontinuing long-term use of levocetirizine or cetirizine. This itching has been reported in patients who used these medicines daily, typically for at least a few months and often for years, and did not experience itching before starting the medication.

Pharmacology

Levocetirizine is an antihistamine. It acts as an inverse agonist that decreases activity at histamine H1 receptors. This in turn prevents the release of other allergy chemicals and increases the blood supply to the area, providing relief from the typical symptoms of hay fever. Levocetirizine, (''R'')-(-)-cetirizine, is essentially a chiral switch of (±)-cetirizine. This enantiomer, the eutomer, is more selective and the (''S'')-counterpart, the distomer, is inactive.

Chemistry

Chemically, levocetirizine is the active levorotary

enantiomer In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...

of cetirizine, also called the ''l''-enantiomer of cetirizine. It is a member of the diphenylmethylpiperazine group of antihistamines.

History

Levocetirizine was first launched in 2001 by the Belgian pharmaceutical company UCB (''Union Chimique Belge'').

Society and culture

Availability

In January 2017, the US

Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...

approved an over-the-counter preparation. Levocetirizine had previously received authorization by the FDA as a prescription drug in 2007, having already been brought to market throughout much of Europe. In India, a prescription-only drug containing levocetirizine hydrochloride and montelukast is sold as Crohist MK.

Brand names

Preparations of levocetirizine are sold under the following brand names: * Xyzal in Australia, Austria, Bulgaria, Croatia, Cyprus, Czech Republic, Finland, France, Hong Kong, Hungary, India, Ireland (also Rinozal), Italy, Japan, Lithuania, Netherlands, Poland, Portugal, Romania, Taiwan, Thailand, Turkey, The Philippines, Serbia, Singapore, Slovakia, Slovenia, South Africa, Switzerland and UK. In May 2007, the US

approved Xyzal, where it is co-marketed by Sanofi-Aventis. * Xazal in Spain. * Avocel, Histrine Levo, and Xybat in Indonesia * Zobral in Cyprus. * Levobert in India. * Xusal in Germany and Mexico. * Xozal in Greece. * Degraler in Chile. * Allevo in Egypt. * Zilola, Histisynt, and Xyzal (UCB) in Hungary. * Alcet, Curin, and Seasonix in Bangladesh. * Vozet and Uvnil in India. * T-Day Syrup in Pakistan. * Curin in Nepal. * Zenaro in the Czech Republic and

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. * Xuzal and Zival in Chile. * Cezera, Levosetil, Robenan, and Xyzal in Serbia. * Rinozal and Xyzal in Ireland. * Xycet in Morocco.

References

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