The enzyme leukotriene-C
4 synthase (EC 4.4.1.20)
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the reaction
:leukotriene C
4 leukotriene A
4 + glutathione
This enzyme belongs to the family of
lyase
In biochemistry, a lyase is an enzyme that catalyzes the breaking (an elimination reaction) of various chemical bonds by means other than hydrolysis (a substitution reaction) and oxidation, often forming a new double bond or a new ring structure. ...
s, specifically the class of carbon-sulfur lyases. The
systematic name of this enzyme class is leukotriene-C
4 glutathione-lyase (leukotriene-A
4-forming). Other names in common use include leukotriene C
4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A
4:glutathione ''S''-leukotrienyltransferase, (7''E'',9''E'',11''Z'',14''Z'')-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening), (7''E'',9''E'',11''Z'',14''Z'')-(5''S'',6''R'')-6-(glutathion-''S''-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates in
arachidonic acid metabolism.
Structural studies
As of late 2007, 3
structures have been solved for this class of enzymes, with
PDB accession codes , , and .
References
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EC 4.4.1
Enzymes of known structure
{{enzyme-stub