Leonard S. Schleifer (born 1953) is an American businessman and is the co-founder and chief executive of the

biotechnology Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used b ...

company

Regeneron Pharmaceuticals Regeneron Pharmaceuticals, Inc. is an American biotechnology company headquartered in Westchester County, New York. The company was founded in 1988. Originally focused on neurotrophic factors and their regenerative capabilities, giving rise to i ...

Early life and education

He was born and raised in a

Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...

family, the son of Florence and Charles Baker Schleifer,New York Times: "Paid Notice: Deaths SCHLEIFER, CHARLES BAKER
December 4, 2011 in

Queens, New York Queens is a borough of New York City, coextensive with Queens County, in the U.S. state of New York. Located on Long Island, it is the largest New York City borough by area. It is bordered by the borough of Brooklyn at the western tip of Long I ...

.Forbes: "Regeneron Chief Leonard Schleifer Becomes A Billionaire After 25 Year Search For New Drugs" by Matthew Herper
February 25, 2014 His father was a sweater manufacturer and

World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...

codebreaker. He graduated with a B.S. from

Cornell University Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach an ...

and a MD-PhD from the

University of Virginia The University of Virginia (UVA) is a Public university#United States, public research university in Charlottesville, Virginia. Founded in 1819 by Thomas Jefferson, the university is ranked among the top academic institutions in the United S ...

where he studied under future Nobel Laureate, Alfred G. Gilman. He then worked at

New York Hospital Weill Cornell Medical Center (previously known as New York Hospital or Old New York Hospital or City Hospital) is a research hospital in New York City. It is part of NewYork-Presbyterian Hospital and the teaching hospital for Cornell University. ...

where he trained to become a

neurologist Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal c ...

and also served as a junior faculty member.

Career

Noticing that the biotechnology company

Genentech Genentech, Inc., is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within R ...

was conducting state-of-the-art research but not on diseases of the nervous system, Schleifer was determined to get into the biotechnology business. Choosing not to accept Gilman's efforts to recruit him as an academic, he found a sponsor in George Sing, a venture capitalist at

Merrill Lynch Merrill (officially Merrill Lynch, Pierce, Fenner & Smith Incorporated), previously branded Merrill Lynch, is an American investment management and wealth management division of Bank of America. Along with BofA Securities, the investment bank ...

, and obtained $1 million in seed capital. He also recruited

George Yancopoulos George D. Yancopoulos (born 1959) is a Greek-American biomedical scientist who is the co-founder, president and chief scientific officer of Regeneron Pharmaceuticals. Yancopoulos is the holder of more than 100 patents. He is a principal inventor ...

, a 28-year-old scientist, to be his partner, and in 1988 they founded Regeneron Pharmaceuticals. After several years of trying to recruit research doctors many of whom preferred to work in academia or for large corporations, they developed their first drug to treat

Lou Gehrig’s disease Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most commo ...

. It was a failure as was their second drug to treat

obesity Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it may negatively affect health. People are classified as obese when their body mass index (BMI)—a person's we ...

. Thereafter, they invited the former Merck & Co. CEO

Roy Vagelos Pindaros Roy Vagelos (born October 8, 1929, in Westfield, New Jersey), better known as P. Roy Vagelos or Roy Vagelos, is an American physician and business executive, who was president and chief executive officer (1985) and chairman (1986) of t ...

to be the chairman of their company and to help to turn the company around. He implemented two strategic changes; only invest in drugs in which the biology of the disorder is fully understood; and do not underestimate the importance of human testing to ensure that what works in the laboratory will also work in the real world.

Eylea

As CEO of Regeneron, Schleifer oversaw the "approval and growth of high-priced drugs." In 2011, Regeneron's first successful drug was Eylea for

age-related macular degeneration Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred or no vision in the center of the visual field. Early on there are often no symptoms. Over time, however, som ...

. Eylea prevented leaky blood vessels in the eye from causing blindness. He licensed the drug to

Aventis Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. Originally, the corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Sy ...

which was then bought by

Sanofi Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. Originally, the corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Syn ...

which had no interest in the eye drug. Sanofi, in order to get out of its commitment, paid Regeneron $50 million and ceded the rights back to Regeneron. The drug was a blockbuster generating $838 million in its first full year and sales increased 55% to $1.3 billion in 2013 making Schleifer a billionaire. In 2014 Eylea grossed $1.735 billion. As CEO Schleifer received a total compensation of $41,965,424 in 2014. According to the "annual collaborative report" from Equilar and

The New York Times ''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid ...

, Schleifer ranked 15th in the May 2015 list of "200 highest-paid CEOs of large publicly traded companies." He ranked first in the list of

biopharmaceutical A biopharmaceutical, also known as a biological medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, t ...

executives with the highest total compensation.

COVID-19 drugs

The subject is currently working on a multi-center, double-blind, Phase 2/3 trial with the partnership Sanofi, to evaluate the antibody agent, Kevzara(TM) for hospitalized patients starting in March 2020, as well as, working on the development of a novel, multi-antibody cocktail to be used as both a prevention of

SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a ...

and treatment for infected patients. Regeneron's apparent privileged access of its experimental Covid-19 therapeutic to Donald Trump and members of the Trump administration drew criticism over ethical concerns.

Personal life

He is married to Harriet (née Partel) Schleifer; they have two children, Adam and David.American Jewish Committee: "Harriet Schleifer"
retrieved March 29, 2014 Harriet has an undergraduate degree from

, two graduate degrees in education from the

and a J.D. degree from St. John's University School of Law. She also serves as a member of the Board of Governors of

American Jewish Committee The American Jewish Committee (AJC) is a Jewish advocacy group established on November 11, 1906. It is one of the oldest Jewish advocacy organizations and, according to ''The New York Times'', is "widely regarded as the dean of American Jewish org ...

and as president of her synagogue. Schleifer has known U.S. President

Donald Trump Donald John Trump (born June 14, 1946) is an American politician, media personality, and businessman who served as the 45th president of the United States from 2017 to 2021. Trump graduated from the Wharton School of the University of Pe ...

for some years, as he is a member of Trump’s golf club in

Westchester County, New York Westchester County is located in the U.S. state of New York. It is the seventh most populous county in the State of New York and the most populous north of New York City. According to the 2020 United States Census, the county had a population o ...

. His son Adam was one of many candidates for the nomination in the 2020

Democratic Primary This is a list of Democratic Party presidential primaries. 1912 This was the first time that candidates were chosen through primaries. New Jersey Governor Woodrow Wilson ran to become the nominee, and faced the opposition of Speaker of the Uni ...

for

New York's 17th congressional district New York's 17th congressional district is a congressional district for the United States House of Representatives located in Southern New York. It includes all of Rockland County and portions of central and northwestern Westchester County, i ...

References

{{DEFAULTSORT:Schleifer, Leonard American chief executives American medical researchers 20th-century American Jews 1953 births American billionaires Cornell University alumni Living people American people of Jewish descent People from Queens, New York 21st-century American Jews