Leo Murphy may refer to:
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Leo Murphy (Australian footballer), Australian rules footballer
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Leo Murphy (baseball)
Leo Joseph "Red" Murphy (January 7, 1889 – August 12, 1960) was a catcher in Major League Baseball who played for the Pittsburgh Pirates during the season. Listed at , 179 lb, Murphy batted and threw right-handed. He was born in Terre Hau ...
, catcher in Major League Baseball
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Leo Murphy (Gaelic footballer), Northern Irish Gaelic footballer
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Leo J. Murphy, merchant and politician in Newfoundland
{{hndis, Murphy, Leo