Leland Harrison (Lee) Hartwell (born October 30, 1939 in
Los Angeles
Los Angeles ( ; es, Los Ángeles, link=no , ), often referred to by its initials L.A., is the largest city in the state of California and the second most populous city in the United States after New York City, as well as one of the world' ...
,
California
California is a U.S. state, state in the Western United States, located along the West Coast of the United States, Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the List of states and territori ...
) is former president and director of the
Fred Hutchinson Cancer Research Center
The Fred Hutchinson Cancer Center, formerly known as the Fred Hutchinson Cancer Research Center and also known as Fred Hutch or The Hutch, is a cancer research institute established in 1975 in Seattle, Washington.
History
The center grew out o ...
in
Seattle
Seattle ( ) is a seaport city on the West Coast of the United States. It is the seat of King County, Washington. With a 2020 population of 737,015, it is the largest city in both the state of Washington and the Pacific Northwest regio ...
,
Washington
Washington commonly refers to:
* Washington (state), United States
* Washington, D.C., the capital of the United States
** A metonym for the federal government of the United States
** Washington metropolitan area, the metropolitan area centered on ...
. He shared the 2001
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...
with
Paul Nurse
Sir Paul Maxime Nurse (born 25 January 1949) is an English geneticist, former President of the Royal Society and Chief Executive and Director of the Francis Crick Institute. He was awarded the 2001 Nobel Prize in Physiology or Medicine along ...
and
Tim Hunt
Sir Richard Timothy Hunt, (born 19 February 1943) is a British biochemist and molecular physiologist. He was awarded the 2001 Nobel Prize in Physiology or Medicine with Paul Nurse and Leland H. Hartwell for their discoveries of protein molecu ...
, for their discoveries of protein molecules that control the division (duplication) of cells.
Working in yeast, Hartwell identified the fundamental role of checkpoints in cell cycle control, and CDC genes such as CDC28, which controls the start of the cycle—the progression through G1.
Education
Hartwell attended
Glendale High School in
Glendale, California
Glendale is a city in the San Fernando Valley and Verdugo Mountains regions of Los Angeles County, California, Los Angeles County, California, United States. At the 2020 United States Census, 2020 U.S. Census the population was 196,543, up from ...
, and then received his
Bachelor of Science
A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years.
The first university to admit a student to the degree of Bachelor of Science was the University of ...
from the
California Institute of Technology
The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...
in 1961. In 1964, he received his
Doctor of Philosophy
A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common Academic degree, degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields ...
in
biology
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...
from the
Massachusetts Institute of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...
. From 1965 to 1968, he worked at the
University of California, Irvine
The University of California, Irvine (UCI or UC Irvine) is a public land-grant research university in Irvine, California. One of the ten campuses of the University of California system, UCI offers 87 undergraduate degrees and 129 graduate and pr ...
as a professor. He moved to the
University of Washington
The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington.
Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattle a ...
in 1968. In a series of experiments from 1970 to 1971, Hartwell discovered the
cell division cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subse ...
(''CDC'') genes in
baker's yeast
Baker's yeast is the common name for the strains of yeast commonly used in baking bread and other bakery products, serving as a leavening agent which causes the bread to rise (expand and become lighter and softer) by converting the fermentable ...
(''
Saccharomyces cerevisiae
''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been o ...
''). These genes regulate the cell cycle and
mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mi ...
s in the genes are involved in some types of
cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
.
Awards and honors
In addition to the
Nobel Prize
The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
, Hartwell has received many awards and honors including the
Louisa Gross Horwitz Prize
The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...
from
Columbia University
Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
in 1995. He became a member of the
National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
in 1987. In 1996, Hartwell joined the faculty of
Fred Hutchinson Cancer Research Center
The Fred Hutchinson Cancer Center, formerly known as the Fred Hutchinson Cancer Research Center and also known as Fred Hutch or The Hutch, is a cancer research institute established in 1975 in Seattle, Washington.
History
The center grew out o ...
and in 1997 became its president and director until he retired in 2010.
In 1998 he received the
Albert Lasker Award for Basic Medical Research
The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...
, and the
Massry Prize
The Massry Prize was established in 1996, and until 2009 was administered by the Meira and Shaul G. Massry Foundation. The Prize, of $40,000 and the Massry Lectureship, is bestowed upon scientists who have made substantial recent contributions in ...
from the
Keck School of Medicine
The Keck School of Medicine of the University of Southern California teaches and trains physicians, biomedical scientists and other healthcare professionals, conducts medical research, and treats patients. Founded in 1885, it is the second oldest ...
,
University of Southern California
The University of Southern California (USC, SC, or Southern Cal) is a Private university, private research university in Los Angeles, California, United States. Founded in 1880 by Robert M. Widney, it is the oldest private research university in C ...
in 2000. On July 9, 2003,
Washington
Washington commonly refers to:
* Washington (state), United States
* Washington, D.C., the capital of the United States
** A metonym for the federal government of the United States
** Washington metropolitan area, the metropolitan area centered on ...
Governor
Gary Locke
Gary Faye Locke (born January 21, 1950) is an American politician and diplomat serving as the interim president of Bellevue College, the largest of the institutions that make up the Washington Community and Technical Colleges system. Locke serv ...
awarded the Medal of Merit, the state's highest honor, to Hartwell. He is also a recipient of the
Komen Brinker Award for Scientific Distinction The Komen Brinker Award for Scientific Distinction was established by Susan G. Komen for the Cure in 1992 to recognize leading scientists for their significant work in advancing research concepts or clinical application in the fields of breast cance ...
.
Research
His earliest publications focused on the isolation of temperature sensitive yeast mutants disabled in basic biological processes, including DNA, RNA and protein synthesis. This led to the identification of the CDC (Cell Division Cycle) genes, which function in promoting the progression through cell division, most notably CDC28, which encodes the yeast Cdk kinase. Other significant discoveries include introduction of the concept of cell cycle "checkpoints", which delay cell division when cellular insults are generated and also the identification and characterization of the mating signal transduction pathway.
Other positions
Hartwell is the Chairman of the Scientific Advisory Board at the
Canary Foundation, a non-profit organization dedicated to developing new technologies for the early detection of
cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
. He is also a founding co-chair of the
Pacific Health Summit
The goal of the Pacific Health Summit is to connect science, industry, and policy for a healthier world. Traditionally, the main work of the Summit has been an annual meeting, where top decision makers convene to discuss how to realize the dream of ...
, and a member of its Executive Committee. In September 2009, it was announced that Hartwell would join the faculty of
Arizona State University
Arizona State University (Arizona State or ASU) is a public research university in the Phoenix metropolitan area. Founded in 1885 by the 13th Arizona Territorial Legislature, ASU is one of the largest public universities by enrollment in the ...
as the Virginia G. Piper Chair of Personalized Medicine and co-director of the
Biodesign Institute
The Biodesign Institute is a major research center known for nature-inspired solutions to global health, sustainability, and security challenges located on the Tempe campus of Arizona State University. The institute is organized into a growing ...
's Center for Sustainable Health with Dr. Michael Birt. He is also adjunct faculty at
Amrita University
Amrita Vishwa Vidyapeetham (or Amrita University) is a private deemed university based in Coimbatore, India. It currently has 7 campuses with 16 constituent schools across the Indian states of Tamil Nadu, Kerala, Andhra Pradesh and Karnataka ...
in India.
Lee Hartwell Award
This award is given to scientists whose research in yeast has made the most impact in the broader areas of biology. Recipients of the award also give a lecture at the biennial Yeast Genetics Meeting.
* 2016 –
Susan Gasser
Susan M. Gasser (born 1955) is a Swiss molecular biologist. She was the Director of the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, from 2004 - 2019, where she also led a research group from 2004 until 2021. She wa ...
, Friedrich Miescher Institute for Biomedical Research
* 2014 –
George Church, Harvard Medical School
* 2012 –
Stan Fields, University of Washington, Seattle
* 2010 –
Randy Schekman
Randy Wayne Schekman (born December 30, 1948) is an American cell biologist at the University of California, Berkeley, former editor-in-chief of ''Proceedings of the National Academy of Sciences'' and former editor of ''Annual Review of Cell and ...
, University of California, Berkeley
* 2008 –
Mitsuhiro Yanagida
is a Japanese molecular biologist known for research on cell cycle and chromosome structure using the fission yeast Schizosaccharomyces pombe. He was elected as a foreign member of the Royal Society on 11 May 2000.
Education and early life
Yana ...
, Kyoto University
* 2006 –
Kim Nasmyth
Kim Ashley Nasmyth (born 18 October 1952) is an English geneticist, the Whitley Professor of Biochemistry at the University of Oxford, a Fellow of Trinity College, Oxford, former scientific director of the Research Institute of Molecular Pat ...
, Oxford University
* 2004 –
Susan Lindquist
Susan Lee Lindquist, ForMemRS (June 5, 1949 – October 27, 2016) was an American professor of biology at MIT specializing in molecular biology, particularly the protein folding problem within a family of molecules known as heat-shock proteins, ...
, Whitehead Institute
* 2002 – Leland Hartwell, Fred Hutchinson Cancer Research Center
References
External links
*
{{DEFAULTSORT:Hartwell, Leland H.
1939 births
Living people
American Nobel laureates
Nobel laureates in Physiology or Medicine
Hartwell Hartwell may refer to:
Places
* Hartwell, Victoria, a neighbourhood of Camberwell in Melbourne, Australia
** Hartwell railway station
England
* Hartwell, Buckinghamshire
* Hartwell, Northamptonshire, a village
* Hartwell, Staffordshire, a loca ...
Hartwell Hartwell may refer to:
Places
* Hartwell, Victoria, a neighbourhood of Camberwell in Melbourne, Australia
** Hartwell railway station
England
* Hartwell, Buckinghamshire
* Hartwell, Northamptonshire, a village
* Hartwell, Staffordshire, a loca ...
University of Washington faculty
Arizona State University faculty
Members of the United States National Academy of Sciences
Recipients of the Albert Lasker Award for Basic Medical Research
Massry Prize recipients
American scientists
Fred Hutchinson Cancer Research Center people