Latrophilin 3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''ADGRL3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
This gene encodes a member of the
latrophilin
Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom ...
subfamily of
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
s (GPCR). Latrophilins may function in both
cell adhesion and
signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular
N-terminal cell adhesion subunit and a subunit with substantial similarity to the
secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.
Clinical significance
A version of this gene has been linked to
attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by excessive amounts of inattention, hyperactivity, and impulsivity that are pervasive, impairing in multiple contexts, and otherwise age-inap ...
(ADHD).
See also
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Adhesion G protein-coupled receptors
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3
PDBe-KBprovides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3
Latrophilins
Biology of attention deficit hyperactivity disorder
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