Lactoylphenylalanine, or Lac-Phe, is a metabolite generated by intense
exercise
Exercise is a body activity that enhances or maintains physical fitness and overall health and wellness.
It is performed for various reasons, to aid growth and improve strength, develop muscles and the cardiovascular system, hone athletic ...
.
In mice, high levels of Lac-Phe in the blood cause a decrease of food intake.
In mammals it is created from
(''S'')-lactate and
L-phenylalanine by the
cytosol nonspecific dipeptidase (CNDP2) protein.
It is classified as ''N''-acyl-alpha-amino acid and pseudodipeptide.
It has also been reported that as an additive ''N''-
L-lactoyl phenylalanine improves the taste of food, conferring an
umami flavor. It is found naturally in significant amounts in some traditional Chinese fermented foods such as preserved pickles and
soy sauce
Soy sauce (also called simply soy in American English and soya sauce in British English) is a liquid condiment of Chinese origin, traditionally made from a fermented paste of soybeans, roasted grain, brine, and '' Aspergillus oryzae'' or ''Asp ...
.
See also
*
Acyl group
In chemistry, an acyl group is a moiety derived by the removal of one or more hydroxyl groups from an oxoacid, including inorganic acids. It contains a double-bonded oxygen atom and an alkyl group (). In organic chemistry, the acyl group (IUPAC ...
**
Lactoyl, the acyl group derived from lactic acid
*
Alpha-amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha ami ...
*
Dipeptide A dipeptide is an organic compound derived from two amino acids. The constituent amino acids can be the same or different. When different, two isomers of the dipeptide are possible, depending on the sequence. Several dipeptides are physiologicall ...
*
Dipeptidase
References
External links
* {{Cite web, first=Derek, author-link=Derek Lowe (chemist), last=Lowe, title=A Metabolite of Exercise , url=https://www.science.org/content/blog-post/metabolite-exercise, website=In the pipeline-science.org , language=en
Amino acid derivatives
Carboxamides
Obesity