LY-215,840 is an ergoline derivative drug developed by Eli Lilly, which acts as a potent and selective

antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, riv ...

at the

serotonin Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...

5-HT₂ and 5-HT₇ receptors. It has anti-

hypertensive Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high bl ...

and muscle relaxant effects in animal studies.

References

5-HT2 antagonists Cyclopentanes Ergolines Eli Lilly and Company brands {{Nervous-system-drug-stub