LP-44 is a drug which acts as a potent and selective
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
at the
5HT7 serotonin receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neur ...
. While LP-44 is less selective than the related compound
LP-12
LP-12 is a drug which acts as a potent agonist at the 5HT7 serotonin receptor, with very high selectivity over other tested receptor subtypes such as the serotonin 5-HT1A and 5-HT2A, and the dopamine D2 receptor. It has been used to research the ...
, it has been more widely used in research and has been used to show the complex role of 5-HT
7 receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.
See also
*
AS-19
*
E-55888
E-55888 is a drug developed by Esteve, which acts as a potent and selective full agonist at the 5HT7 serotonin receptor, and is used for investigating the role of 5-HT7 receptors in the perception of pain. When administered by itself, E-55888 is ...
*
LP-211
LP-211 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels foun ...
References
{{Piperazines
5-HT7 agonists
1-Aminotetralins
Phenylpiperazines