LIM/homeobox protein Lhx3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''LHX3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
''LHX3'' encodes a protein of a large protein family, members of which carry the
LIM domain
LIM domains are protein structural domains, composed of two contiguous zinc fingers, separated by a two-amino acid residue hydrophobic linker. The domain name is an acronym of the three genes in which it was first identified (LIN-11, Isl-1 and ...
, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for
pituitary
In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland, about the size of a chickpea and weighing, on average, in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The hypoph ...
development and
motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.
Clinical significance
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.
Interactions
LHX3 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
Ldb1
LIM domain-binding protein 1 is a protein that in humans is encoded by the ''LDB1'' gene.
Interactions
LDB1 has been shown to interact with LMO4, TCF3, TAL1
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T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem ...
.
References
Further reading
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External links
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Transcription factors
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