L-olivosyl-oleandolide 3-O-methyltransferase (, ''OleY'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:
S-adenosyl-L-methionine
''S''-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throug ...
+ L-olivosyl-oleandolide
S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide
The enzyme is involved in the
biosynthesis
Biosynthesis is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined to form macromolecules. ...
of the
macrolide
The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrol ...
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
oleandomycin
Oleandomycin is a macrolide antibiotic. It is synthesized from strains of ''Streptomyces antibioticus''. It is weaker than erythromycin.
It used to be sold under the brand name Sigmamycine, combined with tetracycline, and made by the company Ro ...
in ''
Streptomyces antibioticus
''Streptomyces antibioticus'' (previously known as ''Actinomyces antibioticus'') is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. Its name is derived from the Greek ''"strepto-"'' meaning ...
''.
References
External links
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EC 2.1.1