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Kurt Benirschke (May 26, 1924 – September 10, 2018) was a
German-American German Americans (german: Deutschamerikaner, ) are Americans who have full or partial German ancestry. With an estimated size of approximately 43 million in 2019, German Americans are the largest of the self-reported ancestry groups by the Unite ...
pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in th ...
,
geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processes ...
and expert on the
placenta The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate mate ...
and
reproduction Reproduction (or procreation or breeding) is the biological process by which new individual organisms – "offspring" – are produced from their "parent" or parents. Reproduction is a fundamental feature of all known life; each individual or ...
in humans and myriad mammalian species. At the San Diego Zoo, he created the world's first frozen zoo for the cryopreservation of genetic material from endangered species.


Early life and education

Benirschke grew up in Glückstadt, a small town in northern Germany. He received his M.D. degree from the
University of Hamburg The University of Hamburg (german: link=no, Universität Hamburg, also referred to as UHH) is a public research university in Hamburg, Germany. It was founded on 28 March 1919 by combining the previous General Lecture System ('' Allgemeines Vo ...
in 1948. He immigrated to the United States in 1949.


Career

After an internship in
New Jersey New Jersey is a state in the Mid-Atlantic and Northeastern regions of the United States. It is bordered on the north and east by the state of New York; on the east, southeast, and south by the Atlantic Ocean; on the west by the Delawa ...
, he trained in pathology at university hospitals affiliated with
Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is cons ...
in
Boston Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- mo ...
. In 1955, he became pathologist of the Boston Lying-in Hospital, now part of the
Brigham and Women's Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two ...
, and there developed his interest in the placenta and reproductive problems. From 1960 to 1970 he was the chairman of the department of pathology at Dartmouth Medical School in
Hanover, New Hampshire Hanover is a town located along the Connecticut River in Grafton County, New Hampshire, United States. As of the 2020 census, its population was 11,870. The town is home to the Ivy League university Dartmouth College, the U.S. Army Corps of En ...
, and pursued his interests in placental pathology and comparative reproductive pathology. There, he developed a passion for comparative cytogenetics, discovering the reason for the sterility of
mule The mule is a domestic equine hybrid between a donkey and a horse. It is the offspring of a male donkey (a jack) and a female horse (a mare). The horse and the donkey are different species, with different numbers of chromosomes; of the two po ...
s and investigating
twin Twins are two offspring produced by the same pregnancy.MedicineNet > Definition of TwinLast Editorial Review: 19 June 2000 Twins can be either ''monozygotic'' ('identical'), meaning that they develop from one zygote, which splits and forms two em ...
ning in
armadillo Armadillos (meaning "little armored ones" in Spanish) are New World placental mammals in the order Cingulata. The Chlamyphoridae and Dasypodidae are the only surviving families in the order, which is part of the superorder Xenarthra, alo ...
s and
marmoset The marmosets (), also known as zaris or sagoin, are 22 New World monkey species of the genera ''Callithrix'', ''Cebuella'', ''Callibella'', and ''Mico''. All four genera are part of the biological family Callitrichidae. The term "marmoset" is ...
s. In 1970, Benirschke moved west to participate in the development of a new medical school of the
University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is ...
(UCSD). He established a genetics laboratory and ran the
autopsy An autopsy (post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death or to evaluate any d ...
service at UCSD. He also chaired the department of pathology for two years. In 1976, Benirschke persuaded the Board of Trustees of the
San Diego Zoo The San Diego Zoo is a zoo in Balboa Park, San Diego, California, housing 4000 animals of more than 650 species and subspecies on of Balboa Park leased from the City of San Diego. Its parent organization, San Diego Zoo Wildlife Alliance, is a p ...
to establish a formal research department. Benirschke led this new research department, which was named the Center for the Reproduction of Endangered Species, until 1987 when he became a member of the Zoo's Board of Trustees. He set up a laboratory at the Zoo to study the
chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins ar ...
s of
mammal Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur ...
s, particularly aspects relating to reproduction and evolution. In collaboration with T.C. Hsu, he published an ''Atlas of Mammalian Chromosomes'' which presented the
karyotype A karyotype is the general appearance of the complete set of metaphase chromosomes in the cells of a species or in an individual organism, mainly including their sizes, numbers, and shapes. Karyotyping is the process by which a karyotype is disce ...
s of 400 different species of mammals. He established at the Zoo a collection of frozen cells and reproductive material from dozens of highly endangered species that became famous as the first " Frozen Zoo". In the 1970s when he began this collection, there was no technology available to make use of it, but he quoted
Daniel Boorstin Daniel Joseph Boorstin (October 1, 1914 – February 28, 2004) was an American historian at the University of Chicago who wrote on many topics in American and world history. He was appointed the twelfth Librarian of the United States Congress i ...
: "You must collect things for reasons you don't yet understand." The Frozen Zoo eventually became a priceless genetic resource. Throughout his career, he moved freely back and forth between human medicine and animal medicine. This inspired the title ''One Medicine'' given to a
Festschrift In academia, a ''Festschrift'' (; plural, ''Festschriften'' ) is a book honoring a respected person, especially an academic, and presented during their lifetime. It generally takes the form of an edited volume, containing contributions from the ...
written by 50 of his colleagues to honor his 60th birthday. In the introduction, O. A. Ryder and M. L. Byrd state, "The acknowledgment that the underlying mechanisms of cellular function and organismal development are highly similar among animals provides the impetus for the title of this volume, ''One Medicine''. It is a tribute to Prof. Kurt Benirschke from his students and colleagues. As such, we attempt to recognize the breadth and depth of his thinking and to acknowledge the significant role he has played in aspects of human medicine, veterinary medicine, and wildlife conservation." In 1994, he was elected a fellow of the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...
. The same year, he retired from the faculty at UCSD. From 1997-2000 he was president of the Zoo's Board of Trustees and looked after the "Proyecto Tagua" in
Paraguay Paraguay (; ), officially the Republic of Paraguay ( es, República del Paraguay, links=no; gn, Tavakuairetã Paraguái, links=si), is a landlocked country in South America. It is bordered by Argentina to the south and southwest, Brazil to t ...
, a breeding facility of the newly discovered species of
peccary A peccary (also javelina or skunk pig) is a medium-sized, pig-like hoofed mammal of the family Tayassuidae (New World pigs). They are found throughout Central and South America, Trinidad in the Caribbean, and in the southwestern area of North ...
. His text (with Peter Kaufmann) on ''Human Placental Pathology'' is the standard text on the subject. In 2008 he was one of the founders of the
Center for Academic Research and Training in Anthropogeny The Center for Academic Research and Training in Anthropogeny (CARTA) is an Organized Research Unit (ORU) at the University of California, San Diego. Formally established in 2008, CARTA is a collaboration between faculty members of UCSD main ca ...
(CARTA), an interdisciplinary research group based at UCSD and devoted to the study of human origins. Benirschke was a member of many societies and authored 30 books and 510 scientific publications. He was described as a "visionary" and a "Renaissance physician".


Personal life

He met his wife Marion, a nurse, during his internship. They were married for 66 years at the time of his death and had three children, two sons and a daughter. One son, Dr. Stephen Benirschke, lives in Seattle and is a foot and ankle
orthopedic surgeon Orthopedic surgery or orthopedics ( alternatively spelt orthopaedics), is the branch of surgery concerned with conditions involving the musculoskeletal system. Orthopedic surgeons use both surgical and nonsurgical means to treat musculoskeletal ...
best known for his specialty with the calcaneus fracture surgery. His other son,
Rolf Benirschke Rolf Joachim Benirschke (born February 7, 1955) is an American former professional football player who was a placekicker in the National Football League (NFL). He played for the San Diego Chargers from 1977 until 1986. He is probably most kno ...
, is a retired placekicker for the
San Diego Chargers The San Diego Chargers were a professional American football team that played in San Diego from 1961 until the end of the 2016 season, before relocating to Los Angeles, where the franchise had played its inaugural 1960 season. The team is now ...
of the
National Football League The National Football League (NFL) is a professional American football league that consists of 32 teams, divided equally between the American Football Conference (AFC) and the National Football Conference (NFC). The NFL is one of the majo ...
. His daughter Ingrid Benirschke-Perkins is the community relations director for CARTA.


References


External links


About Kurt Benirschke
from the site devoted to ''Comparative Placentation'', a volume on animal placentas

by Paul Popescu for the European Cytogeneticists Association

selection of Kurt Benirschke as Father of the Year by San Diego Online {{DEFAULTSORT:Benirschke, Kurt 1924 births 2018 deaths American geneticists American pathologists American zoologists Physicians from California Geisel School of Medicine faculty Fellows of the American Academy of Arts and Sciences German emigrants to the United States Harvard Medical School people University of California, San Diego faculty People from Glückstadt