Krka (company)
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Krka, d. d., Novo mesto is an international generic
pharmaceutical A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...
company A company, abbreviated as co., is a Legal personality, legal entity representing an association of people, whether Natural person, natural, Legal person, legal or a mixture of both, with a specific objective. Company members share a common p ...
with headquarters in
Novo Mesto Novo Mesto (; sl, Novo mesto; also known by other alternative names) is a city on a bend of the Krka River in the City Municipality of Novo Mesto in southeastern Slovenia, close to the border with Croatia. The town is traditionally considered t ...
, Slovenia. As well as a number of companies and representative offices abroad, Krka also had production and distribution centers in
Russia Russia (, , ), or the Russian Federation, is a List of transcontinental countries, transcontinental country spanning Eastern Europe and North Asia, Northern Asia. It is the List of countries and dependencies by area, largest country in the ...
,
Poland Poland, officially the Republic of Poland, is a country in Central Europe. It is divided into 16 administrative provinces called voivodeships, covering an area of . Poland has a population of over 38 million and is the fifth-most populous ...
,
Croatia , image_flag = Flag of Croatia.svg , image_coat = Coat of arms of Croatia.svg , anthem = "Lijepa naša domovino"("Our Beautiful Homeland") , image_map = , map_caption = , capit ...
, and
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
. Krka sells products to more than 70
countries A country is a distinct part of the world, such as a state (polity), state, nation, or other polity, political entity. It may be a sovereign state or make up one part of a larger state. For example, the country of Japan is an independent, so ...
. In 2018, Krka Group’s total sales amounted to 1.332 billion euros. Over the previous five years, average annual sales growth had been at 2.9% rate. At the end of 2018, Krka Group had 11,390 employees.


Activities and products

Krka’s business is founded on
pharmaceutical A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...
and chemical activities. Prescription
pharmaceuticals A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and rel ...
remain its main product group, with an 82.6% share of Krka Group’s total sales. They are followed in sales volume by non-prescription products (9.4%) and animal health products (5%). Its Terme Krka spas, hotels and tourism subsidiary contributed 2.8% of the parent group's sales volume.


Prescription pharmaceuticals

The most important of Krka’s therapeutic groups include treatments for:
cardiovascular disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, h ...
s, alimentary tract diseases and metabolic disorders, and central nervous system diseases. They are followed by the medicines for the systemic treatment of infections, the medicines for the treatment of diseases of the blood and blood-forming organs, and the medicines for urinary tract diseases as well as the medicines for
respiratory system The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies grea ...
diseases. Its portfolio of treatments for cardiovascular disease include
ACE inhibitor Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of hypertension, high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease i ...
s to treat high
blood pressure Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" r ...
(including
enalapril Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. For heart failure, it is generally used with a diuretic, such as furosemide ...
and perindopril), sartans for those unable to tolerate ACE inhibitors (including losartan, valsartan and telmisartan),
statin Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications that reduce illness and mortality in those who are at high risk of cardiovascular disease. They are the most common cholesterol-lowering drugs. Low- ...
s to reduce high
cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell mem ...
levels (including simvastatin, atorvastatin and rosuvastatin) and
clopidogrel Clopidogrel — sold under the brand name Plavix, among others — is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following ...
, a blood clot inhibitor. The company makes proton pump inhibitors for the treatment of ulcers and
reflux Reflux is a technique involving the condensation of vapors and the return of this condensate to the system from which it originated. It is used in industrial and laboratory distillations. It is also used in chemistry to supply energy to reactions ...
are the key group among the medicines for the treatment of alimentary tract diseases and metabolic disorders (lansoprazole, pantoprazole, esomeprazole). In the group of medicines for the treatment of central nervous system diseases, Krka produces antidepressants (venlafaxine, sertraline), antipsychotics (olanzapine, quetiapine), as well as medicines for the treatment of
Parkinson’s Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become ...
and Alzheimer’s diseases. An important indication area also includes anti-microbial products (
clarithromycin Clarithromycin, sold under the brand name Biaxin among others, is an antibiotic used to treat various bacterial infections. This includes strep throat, pneumonia, skin infections, ''H. pylori'' infection, and Lyme disease, among others. Clarith ...
). Krka’s range of products includes
analgesic An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
s, medicines for the treatment of diseases of the respiratory system, benign
prostatic On either side of the urethral crest is a slightly depressed fossa, the prostatic sinus, the floor of which is perforated by numerous apertures, the orifices of the prostatic ducts from the lateral lobes of the prostate The prostate is bo ...
hyperplasia, and type-2
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
.


Non-prescription products

Krka’s non-prescription products are aimed at preventing diseases and treating minor illnesses which do not require medical attention. They include products with an effect on the mouth cavity and the pharynx (Septolete), vitamin and mineral products (Pikovit and Duovit), medicines for cough and cold (Herbion syrups), a preparation promising improved memory and concentration (Bilobil), and an analgesic (Nalgesin S).


Animal health products

Krka’s animal health products include general anti-infectives, antiparasitics and
insecticide Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to b ...
s, products for the alimentary tract and metabolism, and antiseptics and disinfectants.


Health-resort and tourism services

Krka’s line of business is supplemented by health-resort and tourist services of the subsidiary, the Terme Krka Group. It unites the business units of the spa complexes and hotels Terme
Dolenjske Toplice Dolenjske Toplice (; german: Töplitz''Leksikon občin kraljestev in dežel zastopanih v državnem zboru,'' vol. 6: ''Kranjsko''. 1906. Vienna: C. Kr. Dvorna in Državna Tiskarna, p. 164.) is a settlement near Novo Mesto in southeastern Slovenia an ...
, Terme Šmarješke Toplice, the coastal centre Talaso Strunjan, Hoteli
Otočec Otočec (, german: Sankt Peter) is a settlement on the left bank of the Krka River in the City Municipality of Novo Mesto in southeastern Slovenia. The area is part of the traditional region of Lower Carniola and is now included in the Southeast ...
with the only hotel in a castle in Slovenia, and the business Hotel Krka. Terme Krka’s basic line of business is the medical
rehabilitation Rehabilitation or Rehab may refer to: Health * Rehabilitation (neuropsychology), therapy to regain or improve neurocognitive function that has been lost or diminished * Rehabilitation (wildlife), treatment of injured wildlife so they can be retur ...
after cardiovascular and respiratory system diseases, as well as mobility problems.


Markets and business network

Krka is an international company, selling more than 93% of its products in more than 70 countries worldwide. Subsidiaries and representative offices are present in the most important markets, while its production capacity is also located in Russia, Poland, Croatia and Germany. Region East Europe is Krka Group’s largest sales region, representing 30.7% of total sales. It is followed by Region Central Europe with 24% of total sales and Region West Europe with 22.6% of total sales and Overseas Markets with 3.1% of total sales. In addition, Krka also sells its products in Africa, the Arabian Peninsula and the Far East. Krka achieved 12,7% of total sales in Region South-East Europe. Krka sells 6.9% of its products and services in Slovenia, being the leading pharmaceutical producer there. Krka’s markets extend from Lisbon to Vladivostok. Krka has 25 subsidiaries and 20 representative offices abroad, which employ 52.6% of all workers.


Research and development

In 2017 Krka acquired first marketing authorizations for 23 new products in 46 pharmaceutical dosage forms and strengths. In several countries, Krka also obtained 555 new marketing authorizations for various products.


History

Krka’s pharmaceutical laboratory was founded in 1954; two years later it was transformed into a production plant. Krka registered its first
pharmaceuticals A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and rel ...
on the domestic market and made inroads into foreign markets in the 1960s. During this time, Krka supplemented its offer with licensed products, obtaining its first FDA registration for antibiotics production. In the early 1980s, Krka focused on the development of own generic products with added value. In the 1980s, Krka started to develop its marketing network and strengthened its position on European markets. By placing its shares on the
Ljubljana Stock Exchange Ljubljana Stock Exchange or LJSE ( sl, Ljubljanska borza ) is a stock exchange located in Ljubljana, Slovenia. It is Slovenia's only stock exchange. The exchange trades shares of Slovenian companies, as well as bonds and commercial papers. The on ...
in 1997, Krka was transformed into a
public limited company A public limited company (legally abbreviated to PLC or plc) is a type of public company under United Kingdom company law, some Commonwealth of Nations, Commonwealth jurisdictions, and the Republic of Ireland. It is a limited liability company ...
. In 2003, Krka-Rus, a subsidiary of Krka, built a new production facility in Istra, northwest Moscow. The total costs amounted to $45 million. In 2007, Krka acquired its first company abroad.


References


External links

* {{Authority control Slovenian brands Pharmaceutical companies of Slovenia Pharmaceutical companies established in 1954 Economy of Novo Mesto Multinational companies headquartered in Slovenia 1954 establishments in Slovenia