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Dame Kay Elizabeth Davies One or more of the preceding sentences incorporates text from the royalsociety.org website where: (''née'' Partridge; born 1 April 1951) is a British
geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processes ...
. She is Dr Lee's Professor of Anatomy at the
University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...
and a
Fellow A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher education ...
of
Hertford College, Oxford Hertford College ( ), previously known as Magdalen Hall, is a constituent college of the University of Oxford in England. It is located on Catte Street in the centre of Oxford, directly opposite the main gate to the Bodleian Library. The col ...
. She is director of the Medical Research Council (MRC) functional genetics unit, a governor of the
Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
,Kay Davies a director of the Oxford Centre for Gene Function, and a patron and Senior Member of
Oxford University Scientific Society The Oxford University Scientific Society (OUSS) is a student scientific society at the University of Oxford. It was founded in 1882 as the Oxford University Junior Scientific Club. It is one of the oldest undergraduate science societies in the ...
. Her research group has an international reputation for work on
Duchenne muscular dystrophy Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy that primarily affects boys. Muscle weakness usually begins around the age of four, and worsens quickly. Muscle loss typically occurs first in the thighs and pelvis follow ...
(DMD). In the 1980s, she developed a test which allowed for the screening of foetuses whose mothers have a high risk of carrying DMD.


Early life and education

Davies was born in
Stourbridge Stourbridge is a market town in the Metropolitan Borough of Dudley in the West Midlands, England, situated on the River Stour. Historically in Worcestershire, it was the centre of British glass making during the Industrial Revolution. The ...
,
Worcestershire Worcestershire ( , ; written abbreviation: Worcs) is a county in the West Midlands of England. The area that is now Worcestershire was absorbed into the unified Kingdom of England in 927, at which time it was constituted as a county (see H ...
, (now West Midlands). She was educated at the Gig Mill School, Stourbridge County High School for Girls,
Somerville College, Oxford Somerville College, a constituent college of the University of Oxford in England, was founded in 1879 as Somerville Hall, one of its first two women's colleges. Among its alumnae have been Margaret Thatcher, Indira Gandhi, Dorothy Hodgkin, I ...
, and
Wolfson College, Oxford Wolfson College () is a constituent college of the University of Oxford in England. Located in north Oxford along the River Cherwell, Wolfson is an all-graduate college with around sixty governing body fellows, in addition to both research a ...
. She was awarded a Doctor of Philosophy degree in 1976 for research on the structure and function of
chromatin Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important ...
from the slime mould '' Physarum polycephalum''.


Career and research

Davies' research group has an international reputation for work on
Duchenne muscular dystrophy Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy that primarily affects boys. Muscle weakness usually begins around the age of four, and worsens quickly. Muscle loss typically occurs first in the thighs and pelvis follow ...
(DMD). In the 1980s, she developed a test which allowed for the screening of foetuses whose mothers have a high risk of carrying DMD. DMD occurs when the
dystrophin Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the cost ...
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
fails to express in muscle cells due to a mutation in the gene which codes for the protein. In 1989 Davies discovered that the utrophin protein has similar properties to dystrophin and has since shown in mouse models that up regulation of the former protein in muscle cells can compensate for the absence of latter. Davies is currently collaborating with
European Research Council The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific ...
fellow Dr Peter Oliver investigating neurodegenerative and movement disorders. Davies is director of the Medical Research Council (MRC) functional genetics unit, a governor of the
Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
and, with Frances Ashcroft and
Peter Donnelly Sir Peter James Donnelly (born 15 May 1959) is an Australian-British mathematician and Professor of Statistical Science at the University of Oxford, and the CEO of Genomics PLC. He is a specialist in applied probability and has made contribut ...
is a director of the Oxford Centre for Gene Function. She was an Executive Editor of the journal '' Human Molecular Genetics''. and stepped down in 2021. In 2020, together with Richard P. Lifton, she co-chaired a commission report on the contentious subject of Hereditary Human Genome Editing, under the auspices of the
National Academies of Sciences, Engineering, and Medicine The National Academies of Sciences, Engineering, and Medicine (also known as NASEM or the National Academies) are the collective scientific national academy of the United States. The name is used interchangeably in two senses: (1) as an umbrell ...
and the UK
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
. She has published more than 400 papers and won numerous awards for her work. She has been a Governor of the Wellcome Trust since 2008 and became Deputy chairman in 2013-18. She was the recipient of the Women in to Science and Engineering (WISE) Lifetime Achievement Award in 2014. Her former doctoral students include Irene Miguel-Aliaga and Sonja Vernes.


Award and honours

Davies was a founding
Fellow of the Academy of Medical Sciences Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...
(FMedSci) in 1998, and was elected a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemati ...
in 2003. Already a
Commander of the Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established ...
(CBE), she was advanced to
Dame Commander of the Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established ...
(DBE) in the
2008 New Year Honours The New Year Honours 2008 for the Commonwealth realms were announced on 29 December 2007, to celebrate the year passed and mark the beginning of 2008. The recipients of honours are displayed here as they were styled before their new honour, and ...
. She is an Honorary Fellow, Somerville College, University of Oxford. She gave the inaugural Rose Lecture at
Kingston University , mottoeng = "Through Learning We Progress" , established = – gained University Status – Kingston Technical Institute , type = Public , endowment = £2.3 m (2015) , ...
in 2012 and delivered the
Harveian Oration The Harveian Oration is a yearly lecture held at the Royal College of Physicians of London. It was instituted in 1656 by William Harvey, discoverer of the systemic circulation. Harvey made financial provision for the college to hold an annual fea ...
at the
Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...
in 2013. In 2015, she was awarded the William Allan Award by the
American Society of Human Genetics The American Society of Human Genetics (ASHG), founded in 1948, is a professional membership organization for specialists in human genetics. As of 2009, the organization had approximately 8,000 members. The Society's members include researchers, a ...
. She was appointed a Patron of The SMA Trust in September 2016. Davies was awarded the
Croonian Lecture The Croonian Medal and Lecture is a prestigious award, a medal, and lecture given at the invitation of the Royal Society and the Royal College of Physicians. Among the papers of William Croone at his death in 1684, was a plan to endow a single ...
by the
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
in 2018 for "her achievements in developing a prenatal test for Duchenne muscular dystrophy and for her work characterising the binding partners of the protein dystrophin".


Personal life

Davies continued to work with her former husband,
Stephen G. Davies Stephen Graham Davies (born 24 February 1950) is a British chemist and was, until his retirement, the Waynflete Professor of Chemistry at the University of Oxford. Education Davies obtained his Bachelor of Arts degree in 1973 from New ...
, on scientific projects, even after their separation in 2000. Their son studied Biology and gained a doctorate at the
University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1 ...
. She married Christopher Williams in 2019.


References

ISI highly cited researchers {{DEFAULTSORT:Davies, Kay 1951 births Living people Wellcome Trust Principal Research Fellows Alumni of Somerville College, Oxford Alumni of Wolfson College, Oxford British anatomists British geneticists Women geneticists Dames Commander of the Order of the British Empire Female Fellows of the Royal Society Fellows of the Academy of Medical Sciences (United Kingdom) Fellows of Hertford College, Oxford Academic journal editors Wellcome Trust British public health doctors People from Stourbridge Oxford University Press Delegate Dr Lee's Professors of Anatomy Fellows of the Royal Society Fellows of Somerville College, Oxford Professors of Genetics (University of Oxford) 20th-century British non-fiction writers 21st-century British non-fiction writers Women public health doctors