Dame Kay Elizabeth Davies
[ One or more of the preceding sentences incorporates text from the royalsociety.org website where: ] (''née'' Partridge; born 1 April 1951)
[ is a British ]geneticist
A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processes ...
. She is Dr Lee's Professor of Anatomy at the University of Oxford
, mottoeng = The Lord is my light
, established =
, endowment = £6.1 billion (including colleges) (2019)
, budget = £2.145 billion (2019–20)
, chancellor ...
and a Fellow
A fellow is a concept whose exact meaning depends on context.
In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements.
Within the context of higher education ...
of Hertford College, Oxford
Hertford College ( ), previously known as Magdalen Hall, is a constituent college of the University of Oxford in England. It is located on Catte Street in the centre of Oxford, directly opposite the main gate to the Bodleian Library. The col ...
. She is director of the Medical Research Council (MRC) functional genetics unit, a governor of the Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
,[Kay Davies ] a director of the Oxford Centre for Gene Function, and a patron and Senior Member of Oxford University Scientific Society
The Oxford University Scientific Society (OUSS) is a student scientific society at the University of Oxford. It was founded in 1882 as the Oxford University Junior Scientific Club. It is one of the oldest undergraduate science societies in the ...
. Her research group has an international reputation for work on Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy that primarily affects boys. Muscle weakness usually begins around the age of four, and worsens quickly. Muscle loss typically occurs first in the thighs and pelvis follow ...
(DMD). In the 1980s, she developed a test which allowed for the screening of foetuses whose mothers have a high risk of carrying DMD.
Early life and education
Davies was born in Stourbridge
Stourbridge is a market town in the Metropolitan Borough of Dudley in the West Midlands, England, situated on the River Stour. Historically in Worcestershire, it was the centre of British glass making during the Industrial Revolution. The ...
, Worcestershire
Worcestershire ( , ; written abbreviation: Worcs) is a county in the West Midlands of England. The area that is now Worcestershire was absorbed into the unified Kingdom of England in 927, at which time it was constituted as a county (see H ...
, (now West Midlands). She was educated at the Gig Mill School, Stourbridge County High School for Girls, Somerville College, Oxford
Somerville College, a constituent college of the University of Oxford in England, was founded in 1879 as Somerville Hall, one of its first two women's colleges. Among its alumnae have been Margaret Thatcher, Indira Gandhi, Dorothy Hodgkin, I ...
, and Wolfson College, Oxford
Wolfson College () is a constituent college of the University of Oxford in England. Located in north Oxford along the River Cherwell, Wolfson is an all-graduate college with around sixty governing body fellows, in addition to both research a ...
.[ ]
She was awarded a Doctor of Philosophy degree in 1976 for research on the structure and function of chromatin
Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important ...
from the slime mould '' Physarum polycephalum''.
Career and research
Davies' research group has an international reputation for work on Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy that primarily affects boys. Muscle weakness usually begins around the age of four, and worsens quickly. Muscle loss typically occurs first in the thighs and pelvis follow ...
(DMD). In the 1980s, she developed a test which allowed for the screening of foetuses whose mothers have a high risk of carrying DMD. DMD occurs when the dystrophin
Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the cost ...
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
fails to express in muscle cells due to a mutation in the gene which codes for the protein. In 1989 Davies discovered that the utrophin protein has similar properties to dystrophin and has since shown in mouse models that up regulation of the former protein in muscle cells can compensate for the absence of latter.
Davies is currently collaborating with European Research Council
The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific ...
fellow Dr Peter Oliver investigating neurodegenerative and movement disorders.
Davies is director of the Medical Research Council (MRC) functional genetics unit, a governor of the Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...
and, with Frances Ashcroft and Peter Donnelly
Sir Peter James Donnelly (born 15 May 1959) is an Australian-British mathematician and Professor of Statistical Science at the University of Oxford, and the CEO of Genomics PLC. He is a specialist in applied probability and has made contribut ...
is a director of the Oxford Centre for Gene Function. She was an Executive Editor of the journal '' Human Molecular Genetics''. and stepped down in 2021.
In 2020, together with Richard P. Lifton, she co-chaired a commission report on the contentious subject of Hereditary Human Genome Editing, under the auspices of the National Academies of Sciences, Engineering, and Medicine
The National Academies of Sciences, Engineering, and Medicine (also known as NASEM or the National Academies) are the collective scientific national academy of the United States. The name is used interchangeably in two senses: (1) as an umbrell ...
and the UK Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
.
She has published more than 400 papers and won numerous awards for her work. She has been a Governor of the Wellcome Trust since 2008 and became Deputy chairman in 2013-18. She was the recipient of the Women in to Science and Engineering (WISE) Lifetime Achievement Award in 2014.[
Her former doctoral students include Irene Miguel-Aliaga][ and Sonja Vernes.][
]
Award and honours
Davies was a founding Fellow of the Academy of Medical Sciences
Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...
(FMedSci) in 1998, and was elected a Fellow of the Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemati ...
in 2003. Already a Commander of the Order of the British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established ...
(CBE), she was advanced to Dame Commander of the Order of the British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established ...
(DBE) in the 2008 New Year Honours
The New Year Honours 2008 for the Commonwealth realms were announced on 29 December 2007, to celebrate the year passed and mark the beginning of 2008.
The recipients of honours are displayed here as they were styled before their new honour, and ...
.
She is an Honorary Fellow, Somerville College, University of Oxford. She gave the inaugural Rose Lecture at Kingston University
, mottoeng = "Through Learning We Progress"
, established = – gained University Status – Kingston Technical Institute
, type = Public
, endowment = £2.3 m (2015)
, ...
in 2012 and delivered the Harveian Oration
The Harveian Oration is a yearly lecture held at the Royal College of Physicians of London. It was instituted in 1656 by William Harvey, discoverer of the systemic circulation. Harvey made financial provision for the college to hold an annual fea ...
at the Royal College of Physicians
The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...
in 2013. In 2015, she was awarded the William Allan Award by the American Society of Human Genetics
The American Society of Human Genetics (ASHG), founded in 1948, is a professional membership organization for specialists in human genetics. As of 2009, the organization had approximately 8,000 members. The Society's members include researchers, a ...
. She was appointed a Patron of The SMA Trust in September 2016.
Davies was awarded the Croonian Lecture
The Croonian Medal and Lecture is a prestigious award, a medal, and lecture given at the invitation of the Royal Society and the Royal College of Physicians.
Among the papers of William Croone at his death in 1684, was a plan to endow a single ...
by the Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
in 2018 for "her achievements in developing a prenatal test for Duchenne muscular dystrophy and for her work characterising the binding partners of the protein dystrophin".
Personal life
Davies continued to work with her former husband, Stephen G. Davies
Stephen Graham Davies (born 24 February 1950) is a British chemist and was, until his retirement, the Waynflete Professor of Chemistry at the University of Oxford.
Education
Davies obtained his Bachelor of Arts degree in 1973 from New ...
, on scientific projects, even after their separation in 2000.[ Their son studied Biology and gained a doctorate at the ]University of Edinburgh
The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1 ...
. She married Christopher Williams in 2019.
References
ISI highly cited researchers
{{DEFAULTSORT:Davies, Kay
1951 births
Living people
Wellcome Trust Principal Research Fellows
Alumni of Somerville College, Oxford
Alumni of Wolfson College, Oxford
British anatomists
British geneticists
Women geneticists
Dames Commander of the Order of the British Empire
Female Fellows of the Royal Society
Fellows of the Academy of Medical Sciences (United Kingdom)
Fellows of Hertford College, Oxford
Academic journal editors
Wellcome Trust
British public health doctors
People from Stourbridge
Oxford University Press Delegate
Dr Lee's Professors of Anatomy
Fellows of the Royal Society
Fellows of Somerville College, Oxford
Professors of Genetics (University of Oxford)
20th-century British non-fiction writers
21st-century British non-fiction writers
Women public health doctors