Kyle K. Biggar (born 1986) is a Canadian

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

and

molecular biologist Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

. He has been a professor of

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

, and

biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...

Carleton University Carleton University is an English-language public research university in Ottawa, Ontario, Canada. Founded in 1942 as Carleton College, the institution originally operated as a private, non-denominational evening college to serve returning World ...

Ottawa Ottawa (, ; Canadian French: ) is the capital city of Canada. It is located at the confluence of the Ottawa River and the Rideau River in the southern portion of the province of Ontario. Ottawa borders Gatineau, Quebec, and forms the core ...

, Canada since 2017. Biggar was the 2016 recipient of the John Charles Polanyi Prize for his outstanding work in early career research.

Biography

Kyle Kevin Biggar was born in 1986 in

Summerside, Prince Edward Island Summerside is a Canadian city in Prince County, Prince Edward Island. It is the second largest city in the province and the primary service centre for the western part of the island. History Summerside was officially incorporated as a town on ...

. Biggar studied

Biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...

and

Chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

St. Francis Xavier University St. Francis Xavier University is a public undergraduate liberal arts university located in Antigonish, Nova Scotia, Canada. It is a member of the Maple League, a group of primarily undergraduate universities in Eastern Canada. History St. Franc ...

(B.Sc) in Antigonish, Nova-Scotia, Canada, and Biology and Biochemistry at

(Ph.D 2013). His doctoral research focused on the biochemistry of physiological stress response. The well-known Canadian biochemist

Kenneth B. Storey Kenneth B. Storey (born October 23, 1949) is a Canadian scientist whose work draws from a variety of fields including biochemistry and molecular biology. He is a Professor of Biology, Biochemistry and Chemistry at Carleton University in Ottawa, ...

was his thesis advisor during his graduate studies at Carleton University. After completing a post-doctoral fellowship at the

University of Western Ontario The University of Western Ontario (UWO), also known as Western University or Western, is a Public university, public research university in London, Ontario, London, Ontario, Canada. The main campus is located on of land, surrounded by resident ...

Schulich School of Medicine and Dentistry, Biggar came back to his alma mater to become an assistant professor of Biochemistry as of 2016.

Research

Biggar's research includes many different areas from different fields within molecular biology, biochemistry, and physical biochemistry. His main areas of research interest are Oxidative Cell Stress, Functional Proteomics,

Bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...

, and

Molecular Pharmacology ''Molecular Pharmacology'' is a peer-reviewed scientific journal published by the American Society for Pharmacology and Experimental Therapeutics since 1965. It is indexed in MEDLINE, Meta, Scopus, and other databases. According to the ''Journa ...

. He is particularly known for his research in the new field of Non-histone Lysine Methylation and its relation to both functional proteomics and cell stress.

Professional honours

Biggar was the 2016 recipient of the John Charles Polanyi Prize for outstanding work in early career research.

Selected recent publications

* Biggar, K.K., and Storey, K.B. Functional impact of non-coding RNA regulation in extreme stress adaptation. J. Mol. Cell. Biol. In Press. doi.org/10.1093/jmcb/mjx053 * Biggar, K.K., Wang Z. and Li, S. SnapShot: Lysine methylation beyond histones. Mol. Cell 68(5):1016–1016.e1. Invited submission * Singal, S.S., Nygard, K.*,Biggar, K.K.*, Shehab, M.A., S.S.C. Li, Jansson, T. and Gupta, M.B. Interaction between IGFBP-1, protein kinase CSNK-2 and mTOR in HepG2 cells as demonstrated by dual immunofluorescence and ''in situ'' PLA. Am. J. Pathol. ''In press'', ''doi.org/10.1016/j.ajpath.2017.09.009'' * Biggar, K.K., Dawson, N.J. and Storey, K.B. Native protein denaturation using urea. Biotechniques 62(1): xiii (epub) * Shehab, M.A., Biggar, K.K., Singal, S.S., Nygard, K., Li, S.S.C., Jansson, T. and Gupta, M.B. Exposure of decidualized HESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol. Cell. Endo. 452:1-14 * Wu, Z., Connolly, J. and Biggar, K.K. Beyond histones: The expanding roles of lysine methylation. FEBS J. 284(17): 2732-2744 * Biggar, K.K. and Storey, K.B. Exploration of low temperature microRNA function in an anoxia tolerant vertebrate ectotherm, the red eared slider turtle (Trachemys scripta elegans). J. Thermal Biol. In Press * Wu, C.W., Biggar, K.K., Luu, B.E., Szereszewski, K.E. and Storey, K.B. Analysis of microRNA expression during the torpor-arousal cycle of a mammalian hibernator, the 13-lined ground squirrel. Physiol. Genomics DOI: 10.1152/physiolgenomics.00005.2016

References

{{DEFAULTSORT:Biggar, Kyle 1986 births Living people Canadian biochemists Carleton University alumni Academic staff of Carleton University People from Summerside, Prince Edward Island St. Francis Xavier University alumni