Konstantin Nikolaevitch Tretiakoff (; December 26, 1892 – 1958) was a Russian

neuropathologist Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinic ...

. He was born in

Fergana Fergana ( uz, Fargʻona/Фарғона, ), or Ferghana, is a district-level city and the capital of Fergana Region in eastern Uzbekistan. Fergana is about 420 km east of Tashkent, about 75 km west of Andijan, and less than 20 km fr ...

Uzbekistan Uzbekistan (, ; uz, Ozbekiston, italic=yes / , ; russian: Узбекистан), officially the Republic of Uzbekistan ( uz, Ozbekiston Respublikasi, italic=yes / ; russian: Республика Узбекистан), is a doubly landlocked cou ...

, as a son of military physician, who was member of Pierre Bonvalot's first

Pamir Pamir may refer to: Geographical features * Pamir Mountains, a mountain range in Central Asia ** Pamir-Alay, a mountain system in Tajikistan, Kyrgyzstan and Uzbekistan, part of the Pamir Mountains *A pamir (valley) is a high plateau or valley surro ...

expedition. He studied medicine in L'Assistance Publique des Hopitaux de Paris. He received his doctorate in 1919. In his thesis he described degeneration of the ''

substantia nigra The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement. ''Substantia nigra'' is Latin for "black substance", reflecting the fact that parts of the substantia nigra app ...

'' associated with

paralysis agitans Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...

(Parkinson disease). Tretiakof was first to link this anatomic structure with parkinsonism. Between 1922 and 1926 Tretiakoff worked at the Hospício de Juquery, near the city of São Paulo,

Brazil Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area ...

. In 1931 he was appointed Chairman at the new Department of Neuropathology at the Medical Institute in

Saratov Saratov (, ; rus, Сара́тов, a=Ru-Saratov.ogg, p=sɐˈratəf) is the largest city and administrative center of Saratov Oblast, Russia, and a major port on the Volga River upstream (north) of Volgograd. Saratov had a population of 901,36 ...

, USSR, where he spent the rest of his life. In 1910, Fritz Heinrich Lewy discovered what became known as

Lewy bodies Lewy bodies are the inclusion bodies – abnormal aggregations of protein – that develop inside nerve cells affected by Parkinson's disease (PD), the Lewy body dementias ( Parkinson's disease dementia and dementia with Lewy bodies (DLB)), and ...

, and compared them to earlier findings by

Gonzalo Rodríguez Lafora Gonzalo Rodríguez Lafora (25 July 1886 – 27 December 1971) was a Spanish neurologist. He was a disciple of Nicolás Achúcarro and Santiago Ramón y Cajal and one of the most brilliant examples of the Spanish Neurological School (or Cajal Scho ...

. In 1913, Lafora described another case, and acknowledged Lewy as the discoverer, naming them ''cuerpos intracelulares de Lewy'' (Lewy bodies). Trétiakoff found them in 1919 in the

of PD brains, called them ''corps de Lewy'' and is credited with the eponym. Eliasz Engelhardt argued in 2017 that Lafora should be credited with the eponym, because he named them six years before Trétiakoff.

References

* {{DEFAULTSORT:Tretiakoff, Konstantin 1892 births 1958 deaths Soviet neurologists Corresponding Members of the USSR Academy of Medical Sciences Lewy body dementia People from Fergana Soviet pathologists Scientists from Saratov