Pacer (also known as Rubicon-like) is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

that in humans is encoded by the RUBCNL

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. Pacer has been shown to increase cellular autophagy through regulation of PI3KC3. Pacer contains a Rubicon homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7. This domain is shared with RH domain containing family members

Rubicon The Rubicon ( la, Rubico; it, Rubicone ; rgn, Rubicôn ) is a shallow river in northeastern Italy, just north of Rimini. It was known as Fiumicino until 1933, when it was identified with the ancient river Rubicon, famously crossed by Julius Ca ...

and PLEKHM1. Whereas Pacer appears to upregulate autophagic activity, Rubicon is a negative regulator of autophagy.

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Further reading