Keratin 18 is a
type I cytokeratin Type I keratins (or Type I cytokeratins) are cytokeratins that constitute the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. Most of the type I keratins consist of aci ...
. It is, together with its filament partner
keratin 8
Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the ''KRT8'' gene. It is often paired with keratin 18.
Utility as an immunohistochemical stain
Antibodies to CK ...
, perhaps the most commonly found products of the
intermediate filament
Intermediate filaments (IFs) are cytoskeletal structural components found in the cells of vertebrates, and many invertebrates. Homologues of the IF protein have been noted in an invertebrate, the cephalochordate ''Branchiostoma''.
Intermedia ...
gene family. They are expressed in single layer
epithelial tissue
Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellu ...
s of the body. Mutations in this gene have been linked to
cryptogenic cirrhosis
Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the impaired liver function caused by the formation of scar tissue known as fibrosis due to damage caused by liver disease. Damage causes tissue repai ...
. Two transcript variants encoding the same protein have been found for this gene.
Keratin 18 is often used together with
keratin 8
Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the ''KRT8'' gene. It is often paired with keratin 18.
Utility as an immunohistochemical stain
Antibodies to CK ...
and
keratin 19
Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the ''KRT19'' gene. Keratin 19 is a type I keratin.
Function
Keratin 19 is a member of the keratin family. ...
to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate
circulating tumor cell A circulating tumor cell (CTC) is a cell that has shed into the vasculature or lymphatics from a primary tumor and is carried around the body in the blood circulation. CTCs can extravasate and become ''seeds'' for the subsequent growth of additional ...
s in blood.
Interactions
Keratin 18 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
Collagen, type XVII, alpha 1,
DNAJB6
DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the ''DNAJB6'' gene.
Function
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch cal ...
,
Pinin
Pinin is a protein that in humans is encoded by the ''PNN'' gene.
Interactions
Pinin has been shown to interact with Keratin 8, Keratin 18, Keratin 19, CTBP1, RNPS1, PRPF4B, SFRS4
Splicing factor, arginine/serine-rich 4 is a protein that in h ...
and
TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the ''TRADD'' gene.
TRADD is an adaptor protein.
Function
The protein encoded by this gene is a death domain containing adaptor m ...
.
References
Further reading
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Keratins
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