Kenneth Henry Wolfe is an Irish geneticist and Professor of Genomic Evolution at

University College Dublin University College Dublin (commonly referred to as UCD) ( ga, Coláiste na hOllscoile, Baile Átha Cliath) is a public research university in Dublin, Ireland, and a collegiate university, member institution of the National University of Ireland ...

(UCD),

Ireland Ireland ( ; ga, Éire ; Ulster Scots dialect, Ulster-Scots: ) is an island in the Atlantic Ocean, North Atlantic Ocean, in Northwestern Europe, north-western Europe. It is separated from Great Britain to its east by the North Channel (Grea ...

., University College Dublin

Education

Wolfe was educated at

Trinity College, Dublin , name_Latin = Collegium Sanctae et Individuae Trinitatis Reginae Elizabethae juxta Dublin , motto = ''Perpetuis futuris temporibus duraturam'' (Latin) , motto_lang = la , motto_English = It will last i ...

where he was awarded

Bachelor of Arts Bachelor of arts (BA or AB; from the Latin ', ', or ') is a bachelor's degree awarded for an undergraduate program in the arts, or, in some cases, other disciplines. A Bachelor of Arts degree course is generally completed in three or four years ...

degree in

Genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...

in 1986Ken Wolfe's followed by a

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. albu ...

in 1990 for research investigating

synonymous substitution A synonymous substitution (often called a ''silent'' substitution though they are not always silent) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the produced amino acid sequence ...

vascular plant Vascular plants (), also called tracheophytes () or collectively Tracheophyta (), form a large group of land plants ( accepted known species) that have lignified tissues (the xylem) for conducting water and minerals throughout the plant. They al ...

s and

mammal Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or ...

s supervised by Paul M. Sharp.

Research and career

Wolfe's research focuses on

comparative genomics Comparative genomics is a field of biological research in which the genomic features of different organisms are compared. The genomic features may include the DNA sequence, genes, gene order, regulatory sequences, and other genomic structural lan ...

yeast Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom. The first yeast originated hundreds of millions of years ago, and at least 1,500 species are currently recognized. They are estimated to constitut ...

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...

and

bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...

. Work in his laboratory investigates the

evolution Evolution is change in the heritable characteristics of biological populations over successive generations. These characteristics are the expressions of genes, which are passed on from parent to offspring during reproduction. Variation ...

eukaryotic Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...

genome In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding ge ...

s and

chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...

organisation. He is best known for his discovery that the genome of the yeast ''

Saccharomyces cerevisiae ''Saccharomyces cerevisiae'' () (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungus microorganisms). The species has been instrumental in winemaking, baking, and brewing since ancient times. It is believed to have been o ...

'' underwent complete

genome duplication Polyploidy is a condition in which the cells of an organism have more than one pair of ( homologous) chromosomes. Most species whose cells have nuclei ( eukaryotes) are diploid, meaning they have two sets of chromosomes, where each set contain ...

about 100 million years ago, an event that is now known to be the result of

hybridization Hybridization (or hybridisation) may refer to: *Hybridization (biology), the process of combining different varieties of organisms to create a hybrid *Orbital hybridization, in chemistry, the mixing of atomic orbitals into new hybrid orbitals *Nu ...

between two divergent species. This finding reshaped our understanding both of yeast biology, and of mechanisms of

genome evolution Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient ...

in eukaryotes. His subsequent discoveries of similar ancient genome duplications (paleopolyploidy) during

human evolution Human evolution is the evolutionary process within the history of primates that led to the emergence of ''Homo sapiens'' as a distinct species of the hominid family, which includes the great apes. This process involved the gradual development of ...

, and in almost all families of

flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (), commonly called angiosperms. The term "angiosperm" is derived from the Greek words ('container, vessel') and ('seed'), and refers to those plants th ...

s, led to the realisation that whole-genome duplication is widespread. His group also studies the origin and evolution of

mating system A mating system is a way in which a group is structured in relation to sexual behaviour. The precise meaning depends upon the context. With respect to animals, the term describes which males and females mating, mate under which circumstances. Reco ...

s in yeasts, and the process of mating-type switching in which one cell type can change into another by moving or replacing a section of chromosome. Wolfe was a

postdoctoral researcher A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to p ...

with

Jeffrey D. Palmer Jeffrey Donald Palmer is a Distinguished Professor of Biology at Indiana University Bloomington. Education Palmer was educated at Swarthmore College and completed his PhD at Stanford University on the evolution of chloroplast DNA supervised by Win ...

Indiana University Bloomington Indiana University Bloomington (IU Bloomington, Indiana University, IU, or simply Indiana) is a public university, public research university in Bloomington, Indiana. It is the flagship university, flagship campus of Indiana University and, with ...

before returning to Ireland in 1992 to establish his research group in the Genetics Department of Trinity College Dublin, where he remained for over 20 years. In 2013, he moved to

's UCD School of Medicine and Conway Institute. his most highly cited

peer review Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review ...

ed papers have been published in leading

scientific journal In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research. Content Articles in scientific journals are mostly written by active scientists such as s ...

s including ''

Nature Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...

'', ''

PNAS ''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Scien ...

'', ''

The Plant Cell ''The Plant Cell'' is a monthly peer-reviewed scientific journal of plant sciences, especially the areas of cell and molecular biology, genetics, development, and evolution. It is published by the American Society of Plant Biologists. The editor-i ...

'', ''

Genome Research ''Genome Research'' is a peer-reviewed scientific journal published by Cold Spring Harbor Laboratory Press. Disregarding review journals, Genome Research ranks 2nd in the category 'Genetics and Genomics' after Nature Genetics. The focus of the jou ...

'' and ''

Nature Reviews Genetics ''Nature Reviews Genetics'' is a monthly review journal published by Nature Portfolio. It was established in 2000 and covers the full breadth of modern genetics. The editor-in-chief is Linda Koch. The journal publishes review and perspective arti ...

''. Former doctoral students from the Wolfe lab include Mario A. Fares,

Aoife McLysaght Aoife ( , ) is an Irish feminine given name. The name is probably derived from the Irish Gaelic ''aoibh'', which means "beauty" or "radiance". It has been compared to the Gaulish name ''Esvios'' (Latinized ''Esuvius'', feminine ''Esuvia''), which ...

, Estelle Proux-Wéra and Cathal Seoighe.

Awards and honours

Wolfe was elected a Fellow of the Royal Society (FRS) in 2017, One or more of the preceding sentences incorporates text from the royalsociety.org website where: a member of the

Royal Irish Academy The Royal Irish Academy (RIA; ga, Acadamh Ríoga na hÉireann), based in Dublin, is an academic body that promotes study in the sciences, humanities and social sciences. It is Ireland's premier List of Irish learned societies, learned socie ...

(MRIA) in 2000 and a member of the European Molecular Biology Organization (EMBO) in 2010. In 2011 he served as president of the Society for Molecular Biology and Evolution (smbe.org).

References

{{DEFAULTSORT:Wolfe, Kenneth Henry Academics of Trinity College Dublin Academics of University College Dublin Alumni of Trinity College Dublin Fellows of the Royal Society Members of the European Molecular Biology Organization Members of the Royal Irish Academy Irish bioinformaticians Living people Year of birth missing (living people)