Kenneth Olden
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Dr. Kenneth Olden is a scientist whose research revolves around diseases, such as
cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
s, and how chemicals and environmental factors affect them. He was director of the
National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS) conducts research into the effects of the environment on human disease, as one of the 27 institutes and centers of the National Institutes of Health (NIH). It is located in the Rese ...
(NIEHS) and
National Toxicology Program The National Toxicology Program (NTP) is an inter-agency program run by the United States Department of Health and Human Services to coordinate, evaluate, and report on toxicology within public agencies. The National Toxicology Program is headqua ...
, being the first African-American to head an
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
(NIH) institute, a position he held from 1991 to 2005. He was also the director of the
Environmental Protection Agency A biophysical environment is a biotic and abiotic surrounding of an organism or population, and consequently includes the factors that have an influence in their survival, development, and evolution. A biophysical environment can vary in scale f ...
(EPA) and overseer of the Integrated Risk Information System (IRIS). He is a scientist who expressed that socioeconomic factors are related to cancer survival rates and need to be given more attention in scientific research. He has made multiple discoveries in the field, such as finding that the sweetener saccharin is not a chemical that causes cancer and funding research on the effects of bus exhaust on minority children in low-income housing residing in New York City. He faced controversy from multiple organizations over slow assessments during his time overseeing IRIS. He is currently 85 years old.


Early life

Kenneth Olden was born in
Parrottsville, Tennessee Parrottsville is a town in Cocke County, Tennessee, Cocke County, Tennessee, United States. The population was 263 at the 2010 census. Geography Parrottsville is located in northeastern Cocke County at (36.009391, -83.091186) U.S. Route 321, a f ...
on July 22, 1938. He attended Tanner High School, a segregated school and was inspired by the school's principal to attend college. He graduated from Tanner in 1956, and he worked hard shining shoes in order to pay tuition and get into Knoxville College. He graduated in 1960 with a B.S. in biology and a minor in chemistry, and moved on to
University of Michigan , mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As o ...
for a genetics program. He later would receive a M.S. in 1964, and then in 1970 receive a doctorate in cell biology and biochemistry from
Temple University Temple University (Temple or TU) is a public state-related research university in Philadelphia, Pennsylvania. It was founded in 1884 by the Baptist minister Russell Conwell and his congregation Grace Baptist Church of Philadelphia then called Ba ...
.


Career

Olden joined the
National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...
in its cancer biology division as a senior staff fellow in 1974. He was awarded tenure in 1977 and became the first African-American to be named an independent investigator in the cancer institute. He later became chairman of Howard University's
oncology Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's etymological origin is the Greek word ὄγκος (''ó ...
department in 1985, where he focused his work on studying cancers that were prevalent in people of color. In 1991, Olden became the director of the
National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS) conducts research into the effects of the environment on human disease, as one of the 27 institutes and centers of the National Institutes of Health (NIH). It is located in the Rese ...
and
National Toxicology Program The National Toxicology Program (NTP) is an inter-agency program run by the United States Department of Health and Human Services to coordinate, evaluate, and report on toxicology within public agencies. The National Toxicology Program is headqua ...
, being the first African-American to head an NIH institute. During his 14 years as director, the NIEHS made many research contributions on health problems such cancer and birth defects. Olden was elected to the Institute of Medicine of the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
for his discovery that blocking interaction between
fibronectin Fibronectin is a high- molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collage ...
and the
integrin Integrins are transmembrane receptors that facilitate cell-cell and cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, ...
receptor can prevent organ-specific
metastasis Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, ...
of malignant cells. Olden and his team also removed saccharin from causes of human cancer. In July 2012, Olden became director of the National Center for Environmental Assessment, and began to oversee its Integrated Risk Information System. During that time, he and IRIS were criticized for their sluggish pace of assessments by environmental groups, congress and industry. This was mostly due to Olden asking for more input from the chemical industry, delaying the bans on chemicals.


Awards

Olden received the Toxicology Forum's Distinguished Fellow Award, the
United States Secretary of Health and Human Services The United States secretary of health and human services is the head of the United States Department of Health and Human Services, and serves as the principal advisor to the president of the United States on all health matters. The secretary is ...
's Distinguished Service Award, the
American College of Toxicology The American College of Toxicology (ACT) is a professional association dedicated to providing an interactive forum for the advancement and exchange of scientific information in the field of toxicology Toxicology is a scientific discipline, ov ...
's First Distinguished Service Award, and the National Minority Health Leadership Award. Former President
Bill Clinton William Jefferson Clinton ( né Blythe III; born August 19, 1946) is an American politician who served as the 42nd president of the United States from 1993 to 2001. He previously served as governor of Arkansas from 1979 to 1981 and agai ...
also gave him the Presidential Distinguished Executive Rank Award and the Presidential Meritorious Executive Rank Award. Olden also received the Calver Award in 2002, the Sedgwick Medal in 2004, and the
Julius B. Richmond Julius Benjamin Richmond (September 26, 1916 – July 27, 2008) was an American pediatrician and public health administrator. He was a vice admiral in the United States Public Health Service Commissioned Corps and served as the United States Su ...
Award in 2005.


References

{{DEFAULTSORT:Olden, Kenneth Living people 1938 births University of Michigan alumni American scientists 21st-century African-American scientists National Institutes of Health people Temple University alumni Knoxville College alumni 21st-century African-American academics 21st-century American academics Members of the National Academy of Medicine