Kenneth Offit (born February 19, 1955) is an American cancer geneticist and

oncologist Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's etymological origin is the Greek word ὄγκος (''ó ...

. He is currently Chief of the Clinical Genetics Service and the Robert and Kate Niehaus Chair in Inherited Cancer Genomics at

Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in the borough of Manhattan in New York City, founded in 1884 as the New York Cancer Hospital. MSKCC is one of 52 National Cancer Institute– ...

. Offit is also a member of the Program in Cancer Biology and Genetics at the

Sloan-Kettering Institute Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in the borough of Manhattan in New York City, founded in 1884 as the New York Cancer Hospital. MSKCC is one of 52 National Cancer Institute– ...

, Professor of Medicine and Healthcare Policy and Research at

Weill Cornell Medical College The Joan & Sanford I. Weill Medical College of Cornell University is Cornell University's biomedical research unit and medical school located in Upper East Side, Manhattan, New York City, New York. Weill Cornell Medicine is affiliated with NewY ...

, and a member of both the Board of Scientific Counselors of the

National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...

and the Evaluation of Genomic Applications in Practice and Prevention working group of the

U.S. Centers for Disease Control The Centers for Disease Control and Prevention (CDC) is the National public health institutes, national public health agency of the United States. It is a Federal agencies of the United States, United States federal agency, under the United S ...

. Offit has been widely recognized for his discoveries with respect to the genetic bases of breast, colon, and lymphoid cancers. In 2016, he was elected as a Member of the

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...

. In 2018, he was named a Fellow of the

American Society of Clinical Oncology The American Society of Clinical Oncology (ASCO) is a professional organization representing physicians of all oncology sub-specialties who care for people with cancer. Founded in 1964 by Fred Ansfield, Harry Bisel, Herman Freckman, Arnoldus G ...

. In 2021, he was named a fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

Research

In 1996, after the discovery of the

BRCA2 ''BRCA2'' and BRCA2 () are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) ...

gene, Offit and his research group successfully identified the most common mutation on the gene associated with breast and ovarian cancer among individuals of

Ashkenazi Jewish Ashkenazi Jews ( ; he, יְהוּדֵי אַשְׁכְּנַז, translit=Yehudei Ashkenaz, ; yi, אַשכּנזישע ייִדן, Ashkenazishe Yidn), also known as Ashkenazic Jews or ''Ashkenazim'',, Ashkenazi Hebrew pronunciation: , singu ...

ancestry. Offit's group would go on to discover or describe recurrent mutations causing increased risk for colon and prostate cancer, and, in 2013 and 2015, they described two genetic syndromes of inherited childhood

lymphoblastic __NOTOC__ A lymphoblast is a modified naive lymphocyte with altered cell morphology. It occurs when the lymphocyte is activated by an antigen (from antigen-presenting cells) and increased in volume by nucleus and cytoplasm growth as well as new mRN ...

leukemia. Offit was honored for his contributions to the prevention and management of cancer with the 2013

American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ...

Award and Lecture. He is also the author of a textbook, ''Clinical Cancer Genetics: Risk Counseling and Management'', which received an award in Medical Sciences from the

Association of American Publishers The Association of American Publishers (AAP) is the national trade association of the American book publishing industry. AAP lobbies for book, journal, and education publishers in the United States. AAP members include most of the major commercia ...

. In 2018, Offit helped launch the BRCA Founder Outreach Study, which provides free testing for three mutations for all insured people over the age of 25 with at least one grandparent of Ashkenazi heritage.

Life

Offit was born in New York City on February 19, 1955 to Sidney Offit and Dr. Avodah K. Offit (née Komito). Offit attended the

Browning School The Browning School is an independent school for boys in New York City. It was founded in 1888 by John A. Browning. It offers instruction in grades kindergarten through 12th grade. The school is a member of the New York Interschool consortium. ...

and then

Princeton University Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest ins ...

, where he was chairman of '' Tiger Magazine'' and later elected to the University Board of Trustees. After graduating

magna cum laude Latin honors are a system of Latin phrases used in some colleges and universities to indicate the level of distinction with which an academic degree has been earned. The system is primarily used in the United States. It is also used in some So ...

from

Princeton Princeton University is a private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth as the College of New Jersey, Princeton is the fourth-oldest institution of higher education in the United States and one of the ni ...

in 1977, he completed both an M.D. at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

and an M.P.H. at the

Harvard School of Public Health The Harvard T.H. Chan School of Public Health is the public health school of Harvard University, located in the Longwood Medical Area of Boston, Massachusetts. The school grew out of the Harvard-MIT School for Health Officers, the nation's first ...

. In 1984, Offit married Emily Sonnenblick. Sonnenblick is a radiologist at Mount Sinai Hospital and the daughter of cardiologist Edmund Sonnenblick. One of their daughters, Anna Offit, is an assistant professor of law at

Southern Methodist University , mottoeng = "The truth will make you free" , established = , type = Private research university , accreditation = SACS , academic_affiliations = , religious_affiliation = United Methodist Church , president = R. Gerald Turner , prov ...

References

{{DEFAULTSORT:Offit, Kenneth American oncologists American geneticists 1955 births Living people Princeton University alumni Harvard Medical School alumni Browning School alumni Memorial Sloan Kettering Cancer Center physicians Harvard School of Public Health alumni Members of the National Academy of Medicine