Kenneth B. Storey (born October 23, 1949) is a
Canadian
Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of ...
scientist
A scientist is a person who conducts Scientific method, scientific research to advance knowledge in an Branches of science, area of the natural sciences.
In classical antiquity, there was no real ancient analog of a modern scientist. Instead, ...
whose work draws from a variety of fields including
biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
and
molecular biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...
. He is a
Professor
Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who pr ...
of
Biology
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...
,
Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
and
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...
at
Carleton University
Carleton University is an English-language public research university in Ottawa, Ontario, Canada. Founded in 1942 as Carleton College, the institution originally operated as a private, non-denominational evening college to serve returning World ...
in Ottawa, Canada. Storey has a world-wide reputation for his research on biochemical adaptation - the molecular mechanisms that allow animals to adapt to and endure severe environmental stresses such as deep cold, oxygen deprivation, and desiccation.
Biography
Kenneth Storey studied biochemistry at the
University of Calgary
The University of Calgary (U of C or UCalgary) is a public research university located in Calgary, Alberta, Canada. The University of Calgary started in 1944 as the Calgary branch of the University of Alberta, founded in 1908, prior to being ins ...
(B.Sc. '71) and zoology at the University of British Columbia (Ph.D. '74). Storey is a Professor of Biochemistry, cross-appointed in the Departments of Biology, Chemistry and Neuroscience and holds the
Canada Research Chair
Canada Research Chair (CRC) is a title given to certain Canadian university research professors by the Canada Research Chairs Program.
Program goals
The Canada Research Chair program was established in 2000 as a part of the Government of Canada ...
in
Molecular Physiology
Systems biology is the computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic ap ...
at Carleton University in Ottawa, Canada.
Storey is an elected fellow of the
Royal Society of Canada
The Royal Society of Canada (RSC; french: Société royale du Canada, SRC), also known as the Academies of Arts, Humanities and Sciences of Canada (French: ''Académies des arts, des lettres et des sciences du Canada''), is the senior national, bil ...
,
of the
Society for Cryobiology
The Society for Cryobiology is an international scientific society that was founded in 1964. Its objectives are to promote research in low temperature biology, to improve scientific understanding in this field, and to disseminate and aid in the app ...
and of the
American Association for the Advancement of Science
The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...
. He has won fellowships and awards for research excellence including the Fry medal from the Canadian Society of Zoologists (2011), the Flavelle medal from the Royal Society of Canada (2010),
Ottawa Life Sciences Council
Ottawa (, ; Canadian French: ) is the capital city of Canada. It is located at the confluence of the Ottawa River and the Rideau River in the southern portion of the province of Ontario. Ottawa borders Gatineau, Quebec, and forms the core of ...
Basic Research Award (1998),
Killam Senior Research Fellowship(1993–1995), the
Ayerst Award Ayerst is a surname. Notable people with the surname include:
*Fiona Ayerst (born 1965), South African photographer
*Peter Ayerst (1920–2014), Royal Air force officer
* William Ayerst (1830–1904), British clergyman and missionary
*William Ayers ...
from th
Canadian Society for Molecular Biosciences(1989), an E.W.R. Steacie Memorial Fellowship from the
Natural Sciences and Engineering Research Council
The Natural Sciences and Engineering Research Council of Canada (NSERC; french: Conseil de recherches en sciences naturelles et en génie du Canada, CRSNG) is the major federal agency responsible for funding natural sciences and engineering rese ...
of Canada (1984–1986), and four Carleton University Research Achievement Awards. Storey is the author of over 1200 research articles, the editor of seven books, has given over 500 talks at conferences and institutes worldwide, and organized numerous international symposia.
Research
Storey's research includes studies of
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
properties,
gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. The ...
, protein
phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...
,
epigenetics
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "o ...
, and cellular
signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellula ...
mechanisms to seek out the basic principles of how organisms endure and flourish under extreme conditions. He is particularly known within the field of
cryobiology
Cryobiology is the branch of biology that studies the effects of low temperatures on living things within Earth's cryosphere or in science. The word cryobiology is derived from the Greek words κρῧος ryos "cold", βίος ios "life", and λό ...
for his studies of animals that can survive freezing, especially the frozen "frog-sicles" (''
Rana sylvatica
''Lithobates sylvaticus'' or ''Rana sylvatica'', commonly known as the wood frog, is a frog species that has a broad distribution over North America, extending from the boreal forest of the north to the southern Appalachians, with several nota ...
'') that have made his work popular with multiple TV shows and magazines. Storey's studies of the adaptations that allow frogs,
insects
Insects (from Latin ') are pancrustacean hexapod invertebrates of the class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton, a three-part body (head, thorax and abdomen), three pairs of j ...
, and other animals to survive freezing have made major advances in the understanding of how cells, tissues and organs can endure freezing. Storey was also responsible for the discovery that some turtle species are freeze tolerant: newly hatched painted turtles that spend their first winter on land (
''Chrysemys picta marginata & C. p. bellii''). These turtles are unique as they are the only reptiles, and highest vertebrate life form, known to tolerate prolonged natural freezing of extracellular body fluids during winter hibernation. These advances may aid the development of organ cryopreservation technology.
A second area of his research is
metabolic rate depression - understanding the mechanisms by which some animals can reduce their
metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...
and enter a state of hypometabolism or
torpor
Torpor is a state of decreased physiological activity in an animal, usually marked by a reduced body temperature and metabolic rate. Torpor enables animals to survive periods of reduced food availability. The term "torpor" can refer to the time ...
that allows them to survive prolonged environmental stresses. His studies have identified molecular mechanisms that underlie metabolic arrest across phylogeny and that support phenomena including mammalian
hibernation
Hibernation is a state of minimal activity and metabolic depression undergone by some animal species. Hibernation is a seasonal heterothermy characterized by low body-temperature, slow breathing and heart-rate, and low metabolic rate. It most ...
,
estivation
Aestivation ( la, aestas (summer); also spelled estivation in American English) is a state of animal dormancy, similar to hibernation, although taking place in the summer rather than the winter. Aestivation is characterized by inactivity and ...
, and
anoxia- and
ischemia
Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems wi ...
-tolerance. These studies hold key applications for medical science, particularly for preservation technologies that aim to extend the survival time of excised organs in cold or frozen storage.
Additional applications include insights into
hyperglycemia
Hyperglycemia is a condition in which an excessive amount of glucose circulates in the blood plasma. This is generally a blood sugar level higher than 11.1 mmol/L (200 mg/dL), but symptoms may not start to become noticeable until even ...
in
metabolic syndrome
Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL).
Metabolic syndrome ...
and
diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
, and anoxic and ischemic damage caused by
heart attack
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may tr ...
and
stroke
A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functionin ...
. Furthermore, Storey's lab has created several web based programs freely available fo
data management, data plotting, and microRNA analysis
Publication links
Dr. Kenneth B. Storey is among the top 2% of highly cited scientists in the world.
PubMedGoogle Scholar
External links
Storey lab websiteStorey lab research toolsKenneth B. Storey CV
References
{{DEFAULTSORT:Storey, Kenneth B.
1949 births
Canada Research Chairs
Carleton University
Academic staff of Carleton University
Cryobiology
Fellows of the Royal Society of Canada
Living people
Molecular biology
People from Taber, Alberta
University of Calgary alumni