Kelliphite is an acronym for the

organophosphorus compound Organophosphorus compounds are organic compounds containing phosphorus. They are used primarily in pest control as an alternative to chlorinated hydrocarbons that persist in the environment. Some organophosphorus compounds are highly effective in ...

6,6'- 1,1'-Biphenyl-2,2'-diyl)bis(oxy)is ,8-di-tbutyl-1,2,10,11-tetramethylibenzo ,f1,3,2]dioxaphosphepin. This Chiral synthesis, chiral ligand is widely used in

asymmetric synthesis Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecul ...

. In one example, this

ligand In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electr ...

is used to form a

rhodium Rhodium is a chemical element with the symbol Rh and atomic number 45. It is a very rare, silvery-white, hard, corrosion-resistant transition metal. It is a noble metal and a member of the platinum group. It has only one naturally occurring isoto ...

complex to

catalyze Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...

asymmetric

hydroformylation Hydroformylation, also known as oxo synthesis or oxo process, is an industrial process for the production of aldehydes from alkenes. This chemical reaction entails the net addition of a formyl group (CHO) and a hydrogen atom to a carbon-carbon d ...

prochiral In stereochemistry, prochiral molecules are those that can be converted from achiral to chiral in a single step. An achiral species which can be converted to a chiral in two steps is called proprochiral. If two identical substituents are attach ...

olefin In organic chemistry, an alkene is a hydrocarbon containing a carbon–carbon double bond. Alkene is often used as synonym of olefin, that is, any hydrocarbon containing one or more double bonds.H. Stephen Stoker (2015): General, Organic, an ...

s. It has been shown that high substrate concentrations as well as a wide variety of

functional group In organic chemistry, a functional group is a substituent or moiety in a molecule that causes the molecule's characteristic chemical reactions. The same functional group will undergo the same or similar chemical reactions regardless of the rest ...

s are tolerated. {{cite journal , last1 = Cobley , first1 = Christopher J. , last2 = Klosin , first2 = Jerzy , last3 = Qin , first3 = Cheng , last4 = Whiteker , first4 = Gregory T. , title = Parallel Ligand Screening on Olefin Mixtures in Asymmetric Hydroformylation Reactions , journal = Org. Lett. , year = 2004 , volume = 6 , issue = 19 , pmid = 15355031 , pages = 3277–80 , doi = 10.1021/ol0487938

References

Organophosphites Phenol ethers