Keith E. Mostov is an American cell biologist. He received a BA from

University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...

in 1976 and during 1976–77 he was a

Rhodes Scholar The Rhodes Scholarship is an international postgraduate award for students to study at the University of Oxford, in the United Kingdom. Established in 1902, it is the oldest graduate scholarship in the world. It is considered among the world' ...

New College, Oxford New College is one of the constituent colleges of the University of Oxford in the United Kingdom. Founded in 1379 by William of Wykeham in conjunction with Winchester College as its feeder school, New College is one of the oldest colleges at th ...

. Mostov received a

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. albu ...

Biological Science Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary ...

from the

Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

in the laboratory of Nobel laureate

Günter Blobel Günter Blobel (; May 21, 1936 – February 18, 2018) was a Silesian German and American biologist and 1999 Nobel Prize laureate in Physiology for the discovery that proteins have intrinsic signals that govern their transport and localization in t ...

in 1983, and an MD from

Weill Cornell Medicine The Joan & Sanford I. Weill Medical College of Cornell University is Cornell University's biomedical research unit and medical school located in Upper East Side, Manhattan, New York City, New York. Weill Cornell Medicine is affiliated with NewY ...

in 1984. He was a Whitehead Fellow at the

Whitehead Institute Whitehead Institute for Biomedical Research is a non-profit research institute located in Cambridge, Massachusetts, United States that is dedicated to improving human health through basic biomedical research. It was founded as a fiscally indepen ...

of MIT from 1984 to 1989. In 1989, Mostov joined the faculty of the University of California, San Francisco, School of Medicine, where he is currently Professor. Mostov and colleagues discovered and sequenced the

Polymeric Immunoglobulin Receptor Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the ''PIGR'' gene. It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M ...

(pIgR) and proposed the generally accepted model of its pathway and function. Neil E. Simister and Mostov cloned and sequenced the Neonatal Fc Receptor (

FcRn The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the ''FCGRT'' gene. It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and ...

). Mostov and colleagues showed how signals in the pIgR direct its polarized trafficking and how polarized MDCK epithelial cells form three-dimensional structures with lumens and tubules. Mostov and colleagues further found how simple rules cause different branching patterns in kidney as compared to other branching tubular organs

Honors and awards

* Rhodes Scholar * Searle Scholar *Charles E. Culpeper Foundation Medical Scholar * Mallinckrodt Foundation Scholar *NIH NIAID MERIT Award * American Society for Cell Biology ASCB Fellow

References

{{DEFAULTSORT:Mostov, Keith E. 1956 births Living people Rockefeller University alumni Weill Cornell Medical College alumni University of Chicago alumni UCSF School of Medicine faculty Cell biologists 20th-century American biologists 21st-century American biologists Scientists from New York City American Rhodes Scholars