Keith A. Crandall
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Keith A. Crandall is an American
computational biologist Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has fo ...
, bioinformaticist, and
population geneticist Population genetics is a subfield of genetics that deals with genetic differences within and between populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as adaptation, speciation, and popu ...
, at George Washington University, where he is the founding director of the Computational Biology Institute, and professor in the Department of Biostatistics and Bioinformatics.


Education

Crandall received a Bachelor of Arts degree in
mathematics Mathematics is an area of knowledge that includes the topics of numbers, formulas and related structures, shapes and the spaces in which they are contained, and quantities and their changes. These topics are represented in modern mathematics ...
and biology from Kalamazoo College in 1987. He received a Master of Arts degree in
coalescent theory Coalescent theory is a model of how alleles sampled from a population may have originated from a common ancestor. In the simplest case, coalescent theory assumes no recombination, no natural selection, and no gene flow or population structure, m ...
and network estimation of gene genealogies (statistics) from Washington University in St. Louis in 1992. He then proceeded to obtain a Doctor of Philosophy in biology and biomedical sciences from Washington University in St. Louis in 1993, for research supervised by Alan Templeton on the molecular systematics and evolutionary biology in the
crayfish Crayfish are freshwater crustaceans belonging to the clade Astacidea, which also contains lobsters. In some locations, they are also known as crawfish, craydids, crawdaddies, crawdads, freshwater lobsters, mountain lobsters, rock lobsters, mu ...
subgenus ''Procericambarus'' (
Decapoda The Decapoda or decapods (literally "ten-footed") are an order of crustaceans within the class Malacostraca, including many familiar groups, such as crabs, lobsters, crayfish, shrimp and prawns. Most decapods are scavengers. The order is esti ...
: Cambaridae). Crandall then held the
Alfred P. Sloan Alfred Pritchard Sloan Jr. ( ; May 23, 1875February 17, 1966) was an American business executive in the automotive industry. He was a long-time president, chairman and CEO of General Motors Corporation. Sloan, first as a senior executive and lat ...
and National Science Foundation Postdoctoral Fellowships at the University of Texas, studying molecular evolution under advisors Jim Bull and
David Hillis David Mark Hillis (born December 21, 1958 in Copenhagen, Denmark) is an American evolutionary biologist, and the Alfred W. Roark Centennial Professor of Biology at the University of Texas at Austin. He is best known for his studies of molecular e ...
, between 1993 and 1996.


Career and research

In 1996, Crandall joined the faculty of the Department of Zoology at Brigham Young University as an assistant professor, where he served until 2002. He then joined the Departments of Integrative Biology and Microbiology and Molecular Biology at Brigham Young University as an
associate professor Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. Overview In the ''North American system'', used in the United States and many other countries, it is a ...
, and then as a full professor from 2005 to 2006. Crandall was then appointed Chair of the Department of Integrative Biology from 2006 to 2007, and later served as Chair of the Department of Biology from 2007 to 2012. In 2010, Crandall was listed as an
ISI highly cited researcher The Institute for Scientific Information (ISI) was an academic publishing service, founded by Eugene Garfield in Philadelphia in 1956. ISI offered scientometric and bibliographic database services. Its specialty was citation indexing and analysis, ...
. In 2012, Crandall was recruited by George Washington University to found the Computational Biology Institute, where he has since served as its founding director, additionally holding appointments as a professor in the Department of Biological Sciences from 2012 to 2017, a professor in the Department of Epidemiology and Biostatistics from 2018 to 2019, and in the Department of Biostatistics and Bioinformatics since 2019. Crandall also serves as the Director of the George Washington University Milken Institute School of Public Health Genomics Core Facility, co-director of the Informatics Core of the Clinical and Translational Science Institute at Children's National Health System, and co-director of The George Washington University Institute for Biomedical Sciences PhD Program in Genomics and Bioinformatics. Crandall studies the
computational biology Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has fo ...
, population genetics, and bioinformatics of a variety of organisms, from crustaceans to agents of infectious diseases. His lab also focuses on the development and testing of methods for
DNA sequence DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. Th ...
analysis, including leading methods in phylogenetics and microbiome research. He applies these methods and others to the study of the evolution of
infectious diseases An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...
with particular focus on HIV evolution. He is also a leading authority in crustacean evolutionary biology. Crandall has published over 300 peer reviewed publications, as well as three books (''The Evolution of HIV'', ''Algorithms in Bioinformatics,'' and ''Decapod Crustacean Phylogenetics''). Crandall's research has been funded by both the National Science Foundation and the National Institutes of Health as well as from a variety of other agencies, including American Foundation for AIDS Research,
National Geographic ''National Geographic'' (formerly the ''National Geographic Magazine'', sometimes branded as NAT GEO) is a popular American monthly magazine published by National Geographic Partners. Known for its photojournalism, it is one of the most widely ...
, United States Forest Service, Pharmaceutical Research and Manufacturers of America,
Alfred P. Sloan Foundation The Alfred P. Sloan Foundation is an American philanthropic nonprofit organization. It was established in 1934 by Alfred P. Sloan Jr., then-president and chief executive officer of General Motors. The Sloan Foundation makes grants to support or ...
, etc.


Awards and honors

* American Society of Naturalists' Young Investigator Prize - 1994 *Alfred P. Sloan Young Investigator Award - 1996 *
NSF NSF may stand for: Political organizations *National Socialist Front, a Swedish National Socialist party *NS-Frauenschaft, the women's wing of the former German Nazi party *National Students Federation, a leftist Pakistani students' political gr ...
CAREER Award - 1997-2002 *
Fulbright The Fulbright Program, including the Fulbright–Hays Program, is one of several United States Cultural Exchange Programs with the goal of improving intercultural relations, cultural diplomacy, and intercultural competence between the people of ...
Scholar Oxford University - 2000-2001 *Batts Foundation Natural History Lecturer, Kalamazoo College - 2003 * PhRMA Foundation Sabbatical Fellowship in Informatics - 2005-2006 *President,
Society of Systematic Biologists The Society of Systematic Biologists (SSB) started as the Society of Systematic Zoology in 1947. A temporary constitution was adopted at the first meeting on 28 December 1947. The updated "biologists" organization (from "zoology") become incorpora ...
- 2010 *Honors Professor of the Year, Brigham Young University - 2012 *Elected Fellow,
American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...
- 2013 *Faculty Member, Faculty of 1000—Bioinformatics - 2016 *Elected Fellow, Linnean Society of London - 2017


References

{{DEFAULTSORT:Crandall, Keith A. Computational biologists Year of birth missing (living people) Living people American bioinformaticians 20th-century American biologists 21st-century American biologists Population geneticists American geneticists Kalamazoo College alumni George Washington University faculty Washington University in St. Louis alumni Washington University in St. Louis mathematicians Fellows of the American Association for the Advancement of Science Brigham Young University faculty Sloan Research Fellows American people of English descent Fellows of the Linnean Society of London