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Kay Michille Brummond is an American synthetic chemist who is Professor of Chemistry and Associate Dean of Faculty at the
University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the universit ...
. Her interests consider cycloaddition reactions that can realise molecules and natural products for organic photovoltaics and
targeted covalent inhibitors Targeted covalent inhibitors (TCIs) or Targeted Covalent bond, covalent drugs are rationally designed Enzyme inhibitor, inhibitors that bind and then Chemical bond, bond to their target proteins. These inhibitors possess a bond-forming functional gr ...
. She was elected a Fellow of the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
(ACS) in 2010, a Fellow of the AAAS in 2021, and awarded the ACS National Award for Encouraging Women into Careers in the Chemical Sciences in 2021.


Early life and education

Brummond grew up in the town of
Herman Herman may refer to: People * Herman (name), list of people with this name * Saint Herman (disambiguation) * Peter Noone (born 1947), known by the mononym Herman Places in the United States * Herman, Arkansas * Herman, Michigan * Herman, Min ...
in eastern
Nebraska Nebraska () is a state in the Midwestern region of the United States. It is bordered by South Dakota to the north; Iowa to the east and Missouri to the southeast, both across the Missouri River; Kansas to the south; Colorado to the southwe ...
. She grew up on a corn and soybeans farm, and was the first member of her family to attend college. She attended the Tekamah-Herman High School and earned her undergraduate degree in secondary education (B.S.) at the
University of Nebraska–Lincoln The University of Nebraska–Lincoln (Nebraska, NU, or UNL) is a public land-grant research university in Lincoln, Nebraska. Chartered in 1869 by the Nebraska Legislature as part of the Morrill Act of 1862, the school was known as the Universit ...
. She moved to
Pennsylvania State University The Pennsylvania State University (Penn State or PSU) is a Public university, public Commonwealth System of Higher Education, state-related Land-grant university, land-grant research university with campuses and facilities throughout Pennsylvan ...
for her doctoral research, where she focused on organic synthesis with Raymond L. Funk. In 1991, she joined the
University of Rochester The University of Rochester (U of R, UR, or U of Rochester) is a private research university in Rochester, New York. The university grants undergraduate and graduate degrees, including doctoral and professional degrees. The University of Roc ...
, where she spent two years as a postdoctoral researcher with Robert K. Boeckman, Jr.


Research and career

In 1993, Brummond joined the faculty at
West Virginia University West Virginia University (WVU) is a public land-grant research university with its main campus in Morgantown, West Virginia. Its other campuses are those of the West Virginia University Institute of Technology in Beckley, Potomac State College ...
, where she was eventually promoted to associate professor. She moved to the
University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the universit ...
in 2001, where she was promoted to professor in 2006 and elected department chair in 2014. Since 2017, Brummond is serving as the associate dean of faculty for the
Dietrich School of Arts and Sciences The Kenneth P. Dietrich School of Arts and Sciences (Dietrich School or School of Arts and Sciences) is one of the 17 schools and colleges of University of Pittsburgh in Pittsburgh, Pennsylvania. A direct descendant of the 1787-chartered Pittsbur ...
at the
University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the universit ...
. Brummond studies the
Pauson–Khand reaction The Pauson–Khand reaction (or PKR or PK-type reaction) is a chemical reaction described as a 2+2+1.html" ;"title="/nowiki>2+2+1">/nowiki>2+2+1/nowiki> cycloaddition between an alkyne, an alkene and carbon monoxide to form a α,β-cyclopentenone. ...
, targeted covalent inhibitors, transition-metal catalyzed cyclocarbonylation, and dearomative cycloaddition reactions. She works on the design, synthesis, and characterization of
guaianolide In organic chemistry, a guaianolide is a type of sesquiterpene lactone consisting of a gamma-lactone and either a cyclopentane or cyclopentene, both fused to a central cycloheptane or cycloheptene structure. There are two subclasses, structural i ...
analog covalent inhibitors with muted reactivity to thiols. In particular, she is interested in identifying the
structure–activity relationship The structure–activity relationship (SAR) is the relationship between the chemical structure of a molecule and its biological activity. This idea was first presented by Crum-Brown and Fraser in 1865. The analysis of SAR enables the determination o ...
s of these analogs. To assemble the 5,7,5-ring system, Brummond uses an allenic
Pauson–Khand reaction The Pauson–Khand reaction (or PKR or PK-type reaction) is a chemical reaction described as a 2+2+1.html" ;"title="/nowiki>2+2+1">/nowiki>2+2+1/nowiki> cycloaddition between an alkyne, an alkene and carbon monoxide to form a α,β-cyclopentenone. ...
s and other cyclization process. To regulate the thiol reactivity and increase affinity for the kinase and protease targets, Brummond modifies the covalent reactive groups. She has designed novel transition metal catalysts, including Rh(I). She has shown that stereoconvergent allenic
Pauson–Khand reaction The Pauson–Khand reaction (or PKR or PK-type reaction) is a chemical reaction described as a 2+2+1.html" ;"title="/nowiki>2+2+1">/nowiki>2+2+1/nowiki> cycloaddition between an alkyne, an alkene and carbon monoxide to form a α,β-cyclopentenone. ...
s catalysed by Rh(I) can result in highly enantioselective 5,7-ring systems, which enable the
enantioselective synthesis Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecul ...
of compounds such as
thapsigargin Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin is classified as a guaianolide, and is extracted from a plant, ''Thapsia garganica''. It is a tumor promoter in mam ...
. Her approach includes collaborations with computational chemists for the rational design of transition metal catalysts and
ligands In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electro ...
through analysis of transition-state structures and energies to achieve
stereoselective In chemistry, stereoselectivity is the property of a chemical reaction in which a single reactant forms an unequal mixture of stereoisomers during a non-stereospecific creation of a new stereocenter or during a non-stereospecific transformation of ...
reaction products.


Academic service

Brummond has advocated for women and underrepresented groups in science. She has worked with both her home institutions and the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
to improve gender balance, and recognized for this work as the Diversity Catalyst Lecturer by the Open Chemistry Collaborative in Diversity Equity (OXIDE) partnership mechanism in 2014. She established the
University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the universit ...
Summer Undergraduate Research Fellowship (SURF) program, which offers research placements to undergraduate students. She launched various outreach programs to introduce young girls to scientific careers. Brummond has created a list of actions that people can take to become an ally to women working in chemistry, namely;
# Inviting a woman chemist to give a seminar; # Engaging with women’s research; # Developing an inclusivity and/or diversity statement together with your research group; # Nominating a woman for an award; # Educating yourself on gender disparities, and barriers, and know the data; # Celebrating the chemistry achievements of women; # Working to prepare the next generation of women chemists; # Mitigating unconscious biases through your actions; and # Working to fix the institution not the individual.


Symposiums and Conferences Organized

Brummond has been active in organizing or co-organizing several national chemistry conferences including: * Vice Chair - 2003 Organic Reactions and Processes
Gordon Research Conference Gordon Research Conferences are a group of international scientific conferences organized by a non-profit organization of the same name. The conference topics cover frontier research in the biological, chemical, and physical sciences, and thei ...
* Chair - 2004 Organic Reactions and Processes
Gordon Research Conference Gordon Research Conferences are a group of international scientific conferences organized by a non-profit organization of the same name. The conference topics cover frontier research in the biological, chemical, and physical sciences, and thei ...
* Co-organizer - "Accelerated Reaction Discovery" at the Telluride Science Research Center - 2011 to 2021 * Co-organizer - The 44th National Organic Chemistry Symposium, University of Maryland, College Park, MD - 2015 * Executive Officer - The 45th National Organic Chemistry Symposium, UC-Davis CA - 2017


Awards and honors

* 2006
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
Akron Section Award *2007
Carnegie Science Center The Carnegie Science Center is one of the four Carnegie Museums of Pittsburgh, Pennsylvania. It is located in the Chateau neighborhood. It is located across the street from Heinz Field. Overview The Carnegie Science Center is the most visited mu ...
Emerging Female Scientist Award * 2010 Elected Fellow of the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
*2015
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
Pittsburgh Award * 2016 Diversity Catalyst Lecturer, Open Chemistry Collaborative in Diversity Equity (OXIDE) partnership,
Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...
*2016 Harold Kohn Endowed Alumni Lectureship, department of chemistry,
Pennsylvania State University The Pennsylvania State University (Penn State or PSU) is a Public university, public Commonwealth System of Higher Education, state-related Land-grant university, land-grant research university with campuses and facilities throughout Pennsylvan ...
* 2018
University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the universit ...
Provost's Spotlight on Women Leaders Series * 2018 Chancellor's Distinguished Public Service Award * 2020
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
Remarkable Woman in Organic Chemistry * 2021
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
Award for Encouraging Women into Careers in the Chemical Sciences * 2021 Elected Fellow of the
American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...
* 2022 Elected to the Board of Directors of
Organic Syntheses ''Organic Syntheses'' is a peer-reviewed scientific journal that was established in 1921. It publishes detailed and checked procedures for the synthesis of organic compounds. A unique feature of the review process is that all of the data and ex ...


Selected publications

* Eric D. Deihl; Luke T. Jesikiewicz; Logan J. Newman; Peng Liu; Kay M. Brummond * Lauren C. Burrows; Luke T. Jesikiewicz; Peng Liu; Kay M. Brummond * Paul A. Jackson; Henry A. M. Schares; Katherine F. Jones; John C. Widen; Daniel Dempe; Matthew Cuellar; Michael Walters; Daniel A. Harki; Kay M. Brummond * Lauren C. Parrette; Luke T. Jesikiewicz; Gang Lu; Steve J. Geib; Peng Liu; Kay M. Brummond * * Kay M. Brummond; Laura S. Kocsis * For comprehensive listing of publications, see: https://scholar.google.com/citations?user=6iI4MkEAAAAJ&hl=en


References

{{DEFAULTSORT:Brummond, Kay University of Pittsburgh faculty University of Nebraska–Lincoln alumni Pennsylvania State University alumni People from Washington County, Nebraska 20th-century American women scientists American women chemists Fellows of the American Chemical Society Scientists from Nebraska 21st-century American chemists 20th-century American chemists West Virginia University faculty 21st-century American women scientists Living people Year of birth missing (living people)