Karl Gottfried Paul Döhle (6 June 1855 – 7 December 1928) was a German pathologist who was a native of

Mühlhausen Mühlhausen () is a city in the north-west of Thuringia, Germany, north of Niederdorla, the country's geographical centre, north-west of Erfurt, east of Kassel and south-east of Göttingen. Mühlhausen was first mentioned in 967 and bec ...

. He was a student at

Tübingen Tübingen (, , Swabian: ''Dibenga'') is a traditional university city in central Baden-Württemberg, Germany. It is situated south of the state capital, Stuttgart, and developed on both sides of the Neckar and Ammer rivers. about one in thr ...

Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel ...

Strassburg Strasbourg (, , ; german: Straßburg ; gsw, label=Bas Rhin Alsatian, Strossburi , gsw, label=Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the Eur ...

and

Kiel Kiel () is the capital and most populous city in the northern Germany, German state of Schleswig-Holstein, with a population of 246,243 (2021). Kiel lies approximately north of Hamburg. Due to its geographic location in the southeast of the J ...

, where he received his doctorate in 1882. Afterwards he was an assistant at the pathological institute in Kiel, where in 1908 he was appointed head of the pathological institute. In 1921 he attained the title of ''professor ordinarius'' (full professor) at the

University of Kiel Kiel University, officially the Christian-Albrecht University of Kiel, (german: Christian-Albrechts-Universität zu Kiel, abbreviated CAU, known informally as Christiana Albertina) is a university in the city of Kiel, Germany. It was founded in ...

, retiring a few years later in 1924. Döhle is remembered for his work in the field of

histopathology Histopathology (compound of three Greek words: ''histos'' "tissue", πάθος ''pathos'' "suffering", and -λογία '' -logia'' "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease. Spe ...

, particularly in his research of

syphilitic Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and ...

inflammation of the

aorta The aorta ( ) is the main and largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes ...

. He is credited with providing a clear anatomical understanding of

syphilitic aortitis Syphilitic aortitis is inflammation of the aorta associated with the Tertiary syphilis, tertiary stage of syphilis infection. SA begins as inflammation of the adventitia, outermost layer of the blood vessel, including the blood vessels that suppl ...

.Biography
@ NDB/ADB Deutsche Biographie A sometimes-used synonym of syphilitic aortitis is "Döhle-Heller aortitis", named after Döhle and Arnold Ludwig Gotthilf Heller (1840-1913), Döhle's mentor in Kiel. He is also known for the discovery of small (1-3 µ in diameter) light blue-gray

basophilic Basophilic is a technical term used by pathologists. It describes the appearance of cells, tissues and cellular structures as seen through the microscope after a histological section has been stained with a basic dye. The most common such dye is ...

leukocyte White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from mult ...

inclusions in the periphery of

neutrophil Neutrophils (also known as neutrocytes or heterophils) are the most abundant type of granulocytes and make up 40% to 70% of all white blood cells in humans. They form an essential part of the innate immune system, with their functions varying in ...

s, structures that are known today as "

Döhle bodies Döhle bodies are light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1-3 μm in diameter. Not much is known about their formation, but they are thought to be remnants of the ...

Selected writings

* ''Ein Fall von eigentümlicher Aortenerkrankung bei einem Syphilitischen''. (Treatise on syphilitic aortitis), Kiel, 1885. * ''Vorläufige Mittheilung über Blutbefunde bei Masern'', Zentralblatt für allgemeine Pathologie und pathologische Anatomie,

Jena Jena () is a German city and the second largest city in Thuringia. Together with the nearby cities of Erfurt and Weimar, it forms the central metropolitan area of Thuringia with approximately 500,000 inhabitants, while the city itself has a popu ...

, 1892, 3: 150-152. - Preliminary communication on "blood findings" in

measles Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...

. * ''Leukocyteneinschlüsse bei Scharlach'', Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, 1912, 61: 63-68. - Leucocyte inclusions in

scarlet fever Scarlet fever, also known as Scarlatina, is an infectious disease caused by ''Streptococcus pyogenes'' a Group A streptococcus (GAS). The infection is a type of Group A streptococcal infection (Group A strep). It most commonly affects childr ...

References

''Karl Gottfried Paul Döhle''
@

Who Named It ''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliograph ...

{{DEFAULTSORT:Dohle, Karl Gottfried Paul 1855 births 1928 deaths People from Mühlhausen Academic staff of the University of Kiel German histologists German pathologists

Selected writings

See also

References