Karen Elizabeth Keitley Duff (born 1965) is a British scientist known for her work on

Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...

. Her most notable work focused on the development and characterization of mouse models of Alzheimer's disease

amyloid Amyloids are aggregates of proteins characterised by a Fibril, fibrillar morphology of 7–13 Nanometer, nm in diameter, a beta sheet (β-sheet) Secondary structure of proteins, secondary structure (known as cross-β) and ability to be Staining, ...

deposition. She became Centre Director of the UK Dementia Research Institute's hub at

University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...

in Spring 2020. She was educated at the

University of East Anglia The University of East Anglia (UEA) is a public research university in Norwich, England. Established in 1963 on a campus west of the city centre, the university has four faculties and 26 schools of study. The annual income of the institution f ...

(BSc, 1987) and completed her PhD at

Queens' College, Cambridge Queens' College is a constituent college of the University of Cambridge. Queens' is one of the oldest colleges of the university, founded in 1448 by Margaret of Anjou. The college spans the River Cam, colloquially referred to as the "light s ...

in 1991. At

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

she was a student of

Sydney Brenner Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work ...

's department. She was awarded the

Potamkin Prize The Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases was established in 1988 and is sponsored by the American Academy of Neurology. The prize is funded through the philanthropy of the Potamkin Foundation. The prize is awarded ...

in 2006, together with Karen Ashe and Bradley Hyman. In 2020 she was awarded the

British Neuroscience Association The British Neuroscience Association (BNA) is a scientific society with around 2,500 members. Starting out as an informal gathering of scientists meeting at the Black Hourse Public House in London to discuss brain-related topics (the 'London Blac ...

Award for Outstanding Contribution to Neuroscience. She was formerly Professor of Pathology and Cell Biology at

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

. She has an

h-index The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with obvious success indicators such as winn ...

of 95 according to

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. Released in beta in November 2004, the Google Scholar index includes p ...

References

1965 births Living people Alumni of the University of East Anglia Alumni of Queens' College, Cambridge Columbia University faculty British pathologists {{UK-scientist-stub