Sources
KTX is aChemistry
Kaliotoxin is a 4-kDa polypeptide chain, containing 38Target
KTX binds to the Kv1.3Mode of action
The toxin binds to the external vestibule of the channel, and a critical lysine residue (K27), protrudes into the pore and plugs it (Aiyar J et al., 1995, 1996). The positively charged amino-group of the K27 chain fits into the selectivity filter near the G77 chain (References