Kaempferide is an ''O''-methylated flavonol, a type of chemical compound. It can be found in ''

Kaempferia galanga ''Kaempferia galanga'', commonly known as kencur, aromatic ginger, sand ginger, cutcherry, is a monocotyledonous plant in the ginger family, and one of four plants called galangal. It is found primarily in open areas in Indonesia, southern Ch ...

'' (aromatic ginger). It has been noted to inhibit

pancreatic cancer Pancreatic cancer arises when cell (biology), cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a Neoplasm, mass. These cancerous cells have the malignant, ability to invade other parts of t ...

growth by blockading an EGFR-related pathway.

Metabolism

The enzyme kaempferol 4'-''O''-methyltransferase uses ''S''-adenosyl-L-methionine and

kaempferol Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. Kaempferol is a yellow crystalline solid with a meltin ...

to produce ''S''-adenosyl-L-homocysteine and kaempferide.

Glycosides

Icariin Icariin is a chemical compound classified as a prenylated flavonol glycoside, a type of flavonoid. It is the 8-prenyl derivative of kaempferol 3,7-''O''-diglucoside. The compound has been isolated from several species of plant belonging to the ...

is the

tert-amyl alcohol ''tert''-Amyl alcohol (TAA) or 2-methylbutan-2-ol (2M2B), is a branched pentanol. Historically TAA has been used an anesthetic and more recently used as a recreational drug. TAA is mostly a positive allosteric modulator for GABAA receptors in t ...

derivative of kaempferide 3,7-''O''-diglycoside.

References

External links

Kaempferide at the HMDB
O-methylated flavonols {{Aromatic-stub