KRP stands for kinesin related

proteins Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

. bimC is a

subfamily In biological classification, a subfamily (Latin: ', plural ') is an auxiliary (intermediate) taxonomic rank, next below family but more inclusive than genus. Standard nomenclature rules end subfamily botanical names with "-oideae", and zoologi ...

of KRPs and its function is to separate the duplicated centrosomes during

mitosis In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is mainta ...

Role in mitotic repair

Kinesin-13 MCAK (Mitotic Centromere-Associated Kinesin) is a KRP that is involved in resolving errors during mitosis involving kinetochore-microtubules. This process is associated with Aurora B Protein Kinase. When Aurora B's function is disrupted, MCAK ability to locate centromeres, which play a critical role in separation of chromosomes during mitosis, was suppressed. There are other environments in which MCAK's function is impaired, absent impact on its associated kinase. For example, alpha-tubulin detyrosination has been demonstrated to impact MCAK's mitotic repair capabilities, suggesting a potential cause of chromosomal instability.

References

Proteins {{Biochem-stub