Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or K
ir2.3, is a human
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.
Interactions
KCNJ4 has been shown to
interact
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with:
*
CASK,
[
* ]DLG1
Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the ''SAP97'' gene.
SAP97 is a mammalian MAGUK-family member protein that is similar to the Drosophila protein ...
DLG4
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the ''DLG4'' (discs large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAG ...
,LIN7B
Lin-7 homolog B is a protein that in humans is encoded by the ''LIN7B'' gene.
Interactions
LIN7B has been shown to interact with:
* ACCN3,
* GRIN2B,
* KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel t ...
,LIN7C
Lin-7 homolog C is a protein that in humans is encoded by the ''LIN7C'' gene.
Interactions
LIN7C has been shown to interact with:
* DLG1,
* KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in human ...
.
See also
* Inward-rectifier potassium ion channel
Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria. They are activated by phosphatidylinos ...
References
Further reading
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External links
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{{Ion channels, g3