ATP-sensitive inward rectifier potassium channel 12 is a
lipid-gated ion channel that in humans is encoded by the ''KCNJ12''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
This gene encodes an
inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the
Smith–Magenis syndrome
Smith–Magenis Syndrome (SMS), also known as 17p- syndrome, is a microdeletion syndrome characterized by an abnormality in the short (p) arm of chromosome 17. It has features including intellectual disability, facial abnormalities, difficulty sl ...
region on chromosome 17.
Interactions
KCNJ12 has been shown to
interact
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with:
*
APBA1
Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the ''APBA1'' gene.
Function
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that in ...
,
[
* ]CASK
A barrel or cask is a hollow cylindrical container with a bulging center, longer than it is wide. They are traditionally made of wooden staves and bound by wooden or metal hoops. The word vat is often used for large containers for liquids, u ...
,[
* ]DLG1
Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the ''SAP97'' gene.
SAP97 is a mammalian MAGUK-family member protein that is similar to the Drosophila protein ...
,
* DLG2
Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the ''DLG2'' gene.
Function
Chapsyn-110/PSD-93 a member of ...
,[
* ]DLG3
Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the ''DLG3'' gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamil ...
,[
* DLG4,][
* ]LIN7A
Lin-7 homolog A is a protein that in humans is encoded by the ''LIN7A'' gene.
Interactions
LIN7A has been shown to interact with:
* CASK,
* DLG1, and
* KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel t ...
[
* ]LIN7B
Lin-7 homolog B is a protein that in humans is encoded by the ''LIN7B'' gene.
Interactions
LIN7B has been shown to interact with:
* ACCN3,
* GRIN2B,
* KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel ...
,[ and
* ]LIN7C
Lin-7 homolog C is a protein that in humans is encoded by the ''LIN7C'' gene.
Interactions
LIN7C has been shown to interact with:
* DLG1,
* KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in human ...
.
See also
* Inward-rectifier potassium channel
Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria. They are activated by phosphatidylino ...
References
Further reading
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External links
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{{Ion channels, g3
Ion channels