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Joseph Erlanger (January 5, 1874 – December 5, 1965) was an American
physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemica ...
who is best known for his contributions to the field of
neuroscience Neuroscience is the science, scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a Multidisciplinary approach, multidisciplinary science that combines physiology, an ...
. Together with
Herbert Spencer Gasser Herbert Spencer Gasser (July 5, 1888 – May 11, 1963) was an American physiologist, and recipient of the Nobel Prize for Physiology or Medicine in 1944 for his work with action potentials in nerve fibers while on the faculty of Washington Univ ...
, he identified several varieties of
nerve fiber An axon (from Greek ἄξων ''áxōn'', axis), or nerve fiber (or nerve fibre: see spelling differences), is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action p ...
and established the relationship between
action potential An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells ...
velocity and fiber diameter. They were awarded the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordi ...
in 1944 for these achievements.


Biography

Erlanger was born on January 5, 1874, at
San Francisco, California San Francisco (; Spanish for " Saint Francis"), officially the City and County of San Francisco, is the commercial, financial, and cultural center of Northern California. The city proper is the fourth most populous in California and 17t ...
. His family was
Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...
and his parents both immigrated from the
Kingdom of Württemberg The Kingdom of Württemberg (german: Königreich Württemberg ) was a German state that existed from 1805 to 1918, located within the area that is now Baden-Württemberg. The kingdom was a continuation of the Duchy of Württemberg, which existe ...
,
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwee ...
and met in California during the
Gold Rush A gold rush or gold fever is a discovery of gold—sometimes accompanied by other precious metals and rare-earth minerals—that brings an onrush of miners seeking their fortune. Major gold rushes took place in the 19th century in Australia, New ...
. Joseph was the sixth of seven children born to the couple. He completed his
Bachelor of Science A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University o ...
in Chemistry from the
University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant un ...
in 1895. He then completed his M.D. in 1899 from the
Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...
in
Baltimore Baltimore ( , locally: or ) is the most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic, and the 30th most populous city in the United States with a population of 585,708 in 2020. Baltimore was ...
,
Maryland Maryland ( ) is a state in the Mid-Atlantic region of the United States. It shares borders with Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware and the Atlantic Ocean t ...
, where he finished second in his class. Upon graduating, Erlanger interned at
Johns Hopkins Hospital The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 ...
under
William Osler Sir William Osler, 1st Baronet, (; July 12, 1849 – December 29, 1919) was a Canadian physician and one of the "Big Four" founding professors of Johns Hopkins Hospital. Osler created the first residency program for specialty training of phys ...
and worked in a physiology laboratory. Erlanger also gave lectures at the school on digestion and metabolism. Erlanger also had an interest in
cardiology Cardiology () is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular h ...
, specifically the way that excitation transferred from the atrium to the ventricle and researched with Arthur Hirschfelder. Erlanger developed and patented a new type of
sphygmomanometer A sphygmomanometer ( ), a blood pressure monitor, or blood pressure gauge, is a device used to measure blood pressure, composed of an inflatable cuff to collapse and then release the artery under the cuff in a controlled manner, and a mercury ...
that could measure
blood pressure Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure ...
from the
brachial artery The brachial artery is the major blood vessel of the (upper) arm. It is the continuation of the axillary artery beyond the lower margin of teres major muscle. It continues down the ventral surface of the arm until it reaches the cubital foss ...
. While working at
Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...
in 1901, Erlanger published a paper on the digestive systems of canines. This paper caught the attention of William Henry Howell, a
physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemic ...
professor at
Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...
. Howell recruited Erlanger as an Assistant Professor. Erlanger was promoted to Associate Professor some time before 1906. In 1906, Erlanger accepted a position as the first chair of physiology at the
University of Wisconsin A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United Stat ...
in
Madison Madison may refer to: People * Madison (name), a given name and a surname * James Madison (1751–1836), fourth president of the United States Place names * Madison, Wisconsin, the state capital of Wisconsin and the largest city known by this ...
. In 1910, he left to take a position as professor at Washington University in St. Louis; the St. Louis position offered Erlanger more funding for his projects.
Herbert Spencer Gasser Herbert Spencer Gasser (July 5, 1888 – May 11, 1963) was an American physiologist, and recipient of the Nobel Prize for Physiology or Medicine in 1944 for his work with action potentials in nerve fibers while on the faculty of Washington Univ ...
, Erlanger's former student at Wisconsin, joined Erlanger's laboratory soon after the move. During
World War I World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was List of wars and anthropogenic disasters by death toll, one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, ...
, the pair contributed to the research effort examining the effects of
shock Shock may refer to: Common uses Collective noun *Shock, a historic commercial term for a group of 60, see English numerals#Special names * Stook, or shock of grain, stacked sheaves Healthcare * Shock (circulatory), circulatory medical emerge ...
. As part of this work, Erlanger was able to produce
heart block Heart block (HB) is a disorder in the heart's rhythm due to a fault in the natural pacemaker. This is caused by an obstruction – a block – in the electrical conduction system of the heart. Sometimes a disorder can be inherited. Despite the se ...
in an animal model by clamping the
bundle of His The bundle of His (BH) or His bundle (HB) ( "hiss"Medical Terminology for Health Professions, Spiral bound Version'. Cengage Learning; 2016. . pp. 129–.) is a collection of heart muscle cells specialized for electrical conduction. As part of t ...
and tightening it. Together, they managed to amplify the
action potential An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells ...
of a
bullfrog ''Bullfrog'' is a common English language term to refer to large, aggressive frogs, regardless of species. Examples of bullfrogs include: Frog species America * Helmeted water toad (''Calyptocephalella gayi''), endemic to Chile *American bullfr ...
sciatic nerve The sciatic nerve, also called the ischiadic nerve, is a large nerve in humans and other vertebrate animals which is the largest branch of the sacral plexus and runs alongside the hip joint and down the lower limb. It is the longest and widest ...
in 1922 and published the results in the ''
American Journal of Physiology The ''American Journal of Physiology'' is a peer-reviewed scientific journal on physiology published by the American Physiological Society. Vols. for 1898–1941 and 1948-56 include the Society's proceedings, including abstracts of papers present ...
''. It is uncertain why the pair had such a sudden shift in interest to
neuroscience Neuroscience is the science, scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a Multidisciplinary approach, multidisciplinary science that combines physiology, an ...
, as Erlanger was already widely respected in the cardiology field. Erlanger and Gasser were able to modify a
Western Electric The Western Electric Company was an American electrical engineering and manufacturing company officially founded in 1869. A wholly owned subsidiary of American Telephone & Telegraph for most of its lifespan, it served as the primary equipment ma ...
oscilloscope An oscilloscope (informally a scope) is a type of electronic test instrument that graphically displays varying electrical voltages as a two-dimensional plot of one or more signals as a function of time. The main purposes are to display repetiti ...
to run at low voltages. Prior to this modification, the only method available to measure neural activity was the
electroencephalograph Electroencephalography (EEG) is a method to record an electrogram of the spontaneous electrical activity of the brain. The biosignals detected by EEG have been shown to represent the postsynaptic potentials of pyramidal neurons in the neocortex ...
, which could only show large-scale electrical activity. With this technology, they were able to observe that action potentials occurred in two phases—a spike (initial surge) followed by an after-spike (a sequence of slow changes in potential). They discovered that
neuron A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa ...
s were found in many forms, each with their own potential for excitability. With this research, the pair discovered that the velocity of action potentials was directly proportional to the diameter of the nerve fiber. The partnership ended in 1931, when Gasser accepted a position at
Cornell University Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to tea ...
. In 1944, they won the
Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
in Medicine or Physiology for these discoveries. He died of heart disease on December 5, 1965 at St. Louis, Missouri. The Joseph Erlanger House in St. Louis was designated a
National Historic Landmark A National Historic Landmark (NHL) is a building, district, object, site, or structure that is officially recognized by the United States government for its outstanding historical significance. Only some 2,500 (~3%) of over 90,000 places liste ...
on December 8, 1976 as a building of national significance. On January 22, 2009, the
International Astronomical Union The International Astronomical Union (IAU; french: link=yes, Union astronomique internationale, UAI) is a nongovernmental organisation with the objective of advancing astronomy in all aspects, including promoting astronomical research, outreac ...
named a
crater Crater may refer to: Landforms * Impact crater, a depression caused by two celestial bodies impacting each other, such as a meteorite hitting a planet * Explosion crater, a hole formed in the ground produced by an explosion near or below the surf ...
on the
moon The Moon is Earth's only natural satellite. It is the fifth largest satellite in the Solar System and the largest and most massive relative to its parent planet, with a diameter about one-quarter that of Earth (comparable to the width of ...
after him.


Citations


References

* *


External links

* including the Nobel Lecture on December 12, 1946 ''The Discovery of Vitamin K, Its Biological Functions and Therapeutical Application'' *
National Academy of Sciences Biographical Memoir
{{DEFAULTSORT:Erlanger, Joseph 1874 births 1965 deaths Nobel laureates in Physiology or Medicine American Nobel laureates American people of German-Jewish descent American physiologists American neuroscientists Jewish American scientists Johns Hopkins School of Medicine alumni Johns Hopkins University faculty Lowell High School (San Francisco) alumni People from San Francisco Scientists from St. Louis Scientists from Missouri Nobel laureates affiliated with Missouri Washington University in St. Louis faculty University of California, Berkeley alumni