John Farrar Soothill (20 August 1925 – 23 September 2004) was an English medical doctor. He began his career as a

nephrologist Nephrology (from Greek'' nephros'' "kidney", combined with the suffix ''-logy'', "the study of") is a specialty of adult internal medicine and pediatric medicine that concerns the study of the kidneys, specifically normal kidney function (ren ...

and later became a

paediatric Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until the ...

immunologist at

Great Ormond Street Hospital Great Ormond Street Hospital (informally GOSH or Great Ormond Street, formerly the Hospital for Sick Children) is a children's hospital located in the Bloomsbury area of the London Borough of Camden, and a part of Great Ormond Street Hospital ...

Biography

John Soothill was born in 1925 in

Blackheath, London Blackheath is an area in Southeast London, straddling the border of the Royal Borough of Greenwich and the London Borough of Lewisham. It is located northeast of Lewisham, south of Greenwich and southeast of Charing Cross, the traditional ce ...

. His father was the chief medical officer in

Norwich Norwich () is a cathedral city and district of Norfolk, England, of which it is the county town. Norwich is by the River Wensum, about north-east of London, north of Ipswich and east of Peterborough. As the seat of the See of Norwich, with ...

and his grandfather,

William Edward Soothill William Edward Soothill, (1861 – 1935) was a Methodist missionary to China who later became Professor of Chinese at University College, Oxford, and a leading British sinologist. Life Born in Halifax, Yorkshire in January 1861, Soothill m ...

, had been the first professor of

sinology Sinology, or Chinese studies, is an academic discipline that focuses on the study of China primarily through Chinese philosophy, language, literature, culture and history and often refers to Western scholarship. Its origin "may be traced to th ...

Oxford University Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the ...

. He attended

The Leys School The Leys School is a co-educational independent school in Cambridge, England. It is a day and boarding school for about 574 pupils between the ages of eleven and eighteen, and a member of the Headmasters' and Headmistresses' Conference. Histo ...

, Cambridge, and in spite of his

dyslexia Dyslexia, also known until the 1960s as word blindness, is a disorder characterized by reading below the expected level for one's age. Different people are affected to different degrees. Problems may include difficulties in spelling words, r ...

went on to study medicine at

Christ's College, Cambridge Christ's College is a constituent college of the University of Cambridge. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 170 graduate students. The college was founded by William Byngham in 1437 as ...

. He completed his national service in Germany, did his clinical training at

Guy's Hospital Guy's Hospital is an NHS hospital in the borough of Southwark in central London. It is part of Guy's and St Thomas' NHS Foundation Trust and one of the institutions that comprise the King's Health Partners, an academic health science centre. ...

and

Lewisham Hospital University Hospital Lewisham (formerly known as Lewisham Hospital) is a teaching hospital run by Lewisham and Greenwich NHS Trust and serving the London Borough of Lewisham. It is now affiliated with King's College London and forms part of the ...

. In 1955 he travelled to Chicago on a

Fulbright Scholarship The Fulbright Program, including the Fulbright–Hays Program, is one of several United States Cultural Exchange Programs with the goal of improving intercultural relations, cultural diplomacy, and intercultural competence between the people of ...

, where he studied the recently developed technique of

renal biopsy Renal biopsy (also kidney biopsy) is a medical procedure in which a small piece of kidney is removed from the body for examination, usually under a microscope. Microscopic examination of the tissue can provide information needed to diagnose, moni ...

. Soothill began working at

Birmingham University , mottoeng = Through efforts to heights , established = 1825 – Birmingham School of Medicine and Surgery1836 – Birmingham Royal School of Medicine and Surgery1843 – Queen's College1875 – Mason Science College1898 – Mason Univers ...

's experimental pathology department in 1956 as a

. His work at Birmingham centred around

kidney disease Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can ...

immunoglobin An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...

s and the

complement system The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and at ...

. He also pioneered the use of

cyclophosphamide Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer ...

in children with relapsing

nephrotic syndrome Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine, low blood albumin levels, high blood lipids, and significant swelling. Other symptoms may include weight gain, feeling tired, and foamy ...

. In 1965 Soothill moved from Birmingham to the

UCL Great Ormond Street Institute of Child Health The UCL Great Ormond Street Institute of Child Health (ICH) is an academic department of the Faculty of Population Health Sciences of University College London (UCL) and is located in London, United Kingdom. It was founded in 1946 and together ...

, where he was appointed the first Hugh Greenwood Professor of

Immunology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there ...

, a post he would hold for 20 years. One of his main achievements at Great Ormond Street was classifying the different subtypes of

severe combined immunodeficiency Severe combined immunodeficiency (SCID), also known as Swiss-type agammaglobulinemia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in diffe ...

(SCID). The disease, informally known as "boy in the bubble syndrome" after

David Vetter David Phillip Vetter (September 21, 1971 – February 22, 1984) was an American who was a prominent sufferer of severe combined immunodeficiency (SCID), a hereditary disease which dramatically weakens the immune system. Individuals born wit ...

, was given its current name by Soothill in the 1970s. He also focused on childhood allergies, proposing the theory that allergies and

eczema Dermatitis is inflammation of the Human skin, skin, typically characterized by itchiness, erythema, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become lichenification, thick ...

resulted from the exposure to allergens in the first six months of a baby's life. He pioneered the use of

elimination diet An elimination diet, also known as exclusion diet, is a diagnostic procedure used to identify foods that an individual cannot consume without adverse effects. Adverse effects may be due to food allergy, food intolerance, other physiological mechani ...

s whereby a child with an unknown

food allergy A food allergy is an abnormal immune response to food. The symptoms of the allergic reaction may range from mild to severe. They may include itchiness, swelling of the tongue, vomiting, diarrhea, hives, trouble breathing, or low blood pressure ...

is denied all possible allergic sources in their diet, then each food is reintroduced one by one until the causative food is identified. Soothill retired in 1985 to

Devon Devon ( , historically known as Devonshire , ) is a ceremonial and non-metropolitan county in South West England. The most populous settlement in Devon is the city of Plymouth, followed by Devon's county town, the city of Exeter. Devon is ...

with his wife Brenda Thornton, whom he had married in 1951. He died on 23 September 2004 in

Axminster Axminster is a market town and civil parish on the eastern border of the county of Devon in England. It is from the county town of Exeter. The town is built on a hill overlooking the River Axe which heads towards the English Channel at Axmou ...

References

{{DEFAULTSORT:Soothill, John 1925 births 2004 deaths British immunologists British nephrologists British paediatricians People educated at The Leys School Alumni of Christ's College, Cambridge Medical doctors from Norwich Physicians of Guy's Hospital Physicians of Great Ormond Street Hospital