John Hilton Edwards (26 March 1928 – 11 October 2007) was a British medical

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processe ...

. Edwards reported the first description of a

syndrome A syndrome is a set of medical signs and symptoms which are correlated with each other and often associated with a particular disease or disorder. The word derives from the Greek σύνδρομον, meaning "concurrence". When a syndrome is paired ...

of multiple

congenital A birth defect, also known as a congenital disorder, is an abnormal condition that is present at birth regardless of its cause. Birth defects may result in disabilities that may be physical, intellectual, or developmental. The disabilities can ...

malformation A birth defect, also known as a congenital disorder, is an abnormal condition that is present at birth regardless of its cause. Birth defects may result in disabilities that may be physical, intellectual, or developmental. The disabilities can r ...

s associated the presence of an extra

chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...

. The extra chromosome belonged to the E group of chromosomes which consisted of chromosomes 16, 17 and 18. The condition is now known as

Edwards syndrome Edwards syndrome, also known as trisomy 18, is a genetic disorder caused by the presence of a third copy of all or part of chromosome 18. Many parts of the body are affected. Babies are often born small and have heart defects. Other features in ...

trisomy 18 A trisomy is a type of polysomy in which there are three instances of a particular chromosome, instead of the normal two. A trisomy is a type of aneuploidy (an abnormal number of chromosomes). Description and causes Most organisms that reprodu ...

syndrome. In 1979, Edwards was elected to fellowship of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

. He was a

Fellow A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher education ...

Keble College, Oxford Keble College () is one of the constituent colleges of the University of Oxford in England. Its main buildings are on Parks Road, opposite the University Museum and the University Parks. The college is bordered to the north by Keble Road, to th ...

, and Professor of Genetics at

Oxford Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the ...

from 1979 to 1995. He was the son of the surgeon Harold C. Edwards. His brother is the geneticist and statistician A.W.F. Edwards. Early in his career, he worked under

Lancelot Hogben Lancelot Thomas Hogben FRS FRSE (9 December 1895 – 22 August 1975) was a British experimental zoologist and medical statistician. He developed the African clawed frog ''(Xenopus laevis)'' as a model organism for biological research in his ear ...

, and was sometimes distinguished from the brother as "Hogben's Edwards".

References

External links

Further information

John Hilton Edwards
(a short biography). *

Obituaries

Professor John Edwards obituary, ''The Independent''

BMJ obituary

1928 births 2007 deaths British geneticists Medical geneticists Fellows of the Royal Society People educated at Uppingham School Academics of the University of Birmingham Professors of Genetics (University of Oxford) Fellows of Keble College, Oxford {{UK-med-bio-stub